In Vitro and In Vivo Characterization of a Novel Antibody-Like Single-Chain TCR Human IgG1 Fusion Protein

We have constructed a protein composed of a soluble single-chain TCR genetically linked to the constant domain of an IgG1 H chain. The Ag recognition portion of the protein binds to an unmutated peptide derived from human p53 (aa 264-272) presented in the context of HLA-A2.1, whereas the IgG1 H chai...

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Veröffentlicht in:	The Journal of immunology (1950) 2005-04, Vol.174 (7), p.4381-4388
Hauptverfasser:	Mosquera, Luis A, Card, Kimberlyn F, Price-Schiavi, Shari A, Belmont, Heather J, Liu, Bai, Builes, Janette, Zhu, Xiaoyun, Chavaillaz, Pierre-Andre, Lee, Hyung-il, Jiao, Jin-an, Francis, John L, Amirkhosravi, Ali, Wong, Richard L, Wong, Hing C
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Neoplasm - chemistry Antigens, Neoplasm - immunology Cell Line Cytotoxicity, Immunologic Dimerization HLA-A2 Antigen - immunology Humans Immunoglobulin G - genetics Immunoglobulin G - immunology Immunotherapy - methods Neoplasms - therapy Peptide Fragments - immunology Protein Binding Protein Engineering - methods Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology Recombinant Fusion Proteins - immunology Recombinant Fusion Proteins - therapeutic use Tumor Suppressor Protein p53 - immunology
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