Xanthine oxidase, nitric oxide synthase and phospholipase A(2) produce reactive oxygen species via mitochondria

The formation of reactive oxygen species (ROS) has been suggested to be associated with excitotoxicity but the involvement of cytoplasmic enzymes in ROS formation is not clearly known. In the present study, we examined the role of xanthine oxidase (XO), nitric oxide synthase (NOS) and phospholipase...

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Veröffentlicht in:	Brain research 2005-03, Vol.1037 (1-2), p.200-203
Hauptverfasser:	Sanganahalli, Basavaraju G, Joshi, Preeti G, Joshi, Nanda B
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetophenones - pharmacology Allopurinol - pharmacology Animals Cerebral Cortex - drug effects Cerebral Cortex - enzymology Enzyme Inhibitors - pharmacology Mitochondria - drug effects Mitochondria - enzymology Nerve Tissue Proteins - antagonists & inhibitors Nerve Tissue Proteins - metabolism NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type I Phospholipases A - antagonists & inhibitors Phospholipases A - metabolism Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Xanthine Oxidase - antagonists & inhibitors Xanthine Oxidase - metabolism
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