Bromodomain analysis of Brd2-dependent transcriptional activation of cyclin A

Cyclin A is regulated primarily through transcription control during the mammalian cell cycle. A dual mechanism of cyclin A transcriptional repression involves, on the one hand, promoter-bound inhibitory complexes of E2F transcription factors and RB (retinoblastoma) family proteins, and on the other...

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Veröffentlicht in:	Biochemical journal 2005-04, Vol.387 (Pt 1), p.257-269
Hauptverfasser:	Sinha, Anupama, Faller, Douglas V, Denis, Gerald V
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferases - metabolism Animals Cell Cycle - physiology Cell Cycle Proteins - physiology Cell Line Cell Proliferation Chromatin Immunoprecipitation - methods Chromosomal Proteins, Non-Histone Cyclin A - metabolism DNA-Binding Proteins - deficiency DNA-Binding Proteins - physiology E2F Transcription Factors E2F1 Transcription Factor Histone Acetyltransferases Humans Kidney - cytology Kidney - embryology Kidney - enzymology Mice NIH 3T3 Cells Phosphotransferases - metabolism Promoter Regions, Genetic - physiology Protein-Serine-Threonine Kinases - biosynthesis Protein-Serine-Threonine Kinases - physiology Retinoblastoma Protein - deficiency Retinoblastoma Protein - physiology Transcription Factors - deficiency Transcription Factors - physiology Transcriptional Activation - physiology
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