Osteopontin is not a specific marker in malignant pleural mesothelioma
Osteopontin (OPN) is an integrin-binding protein recently shown to be related to tumorigenesis, progression and metastasis in different experimental models of malignancy. Malignant pleural mesothelioma (MPM) is a fatal disease in which the prognosis remains very poor and the knowledge of predictive...
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| Veröffentlicht in: | The International journal of biological markers 2009-04, Vol.24 (2), p.112-117 |
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| container_title | The International journal of biological markers |
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| creator | PALEARI, Laura ROTOLO, Nicola IMPERATORI, Andrea PUZONE, Roberto SESSA, Fausto FRANZI, Francesca MEACCI, Elisa CAMPLESE, Pierpaolo CESARIO, Alfredo PAGANUZZI, Michela |
| description | Osteopontin (OPN) is an integrin-binding protein recently shown to be related to tumorigenesis, progression and metastasis in different experimental models of malignancy. Malignant pleural mesothelioma (MPM) is a fatal disease in which the prognosis remains very poor and the knowledge of predictive factors for outcome is insufficient. The identification of new molecules involved in cancer initiation and development is a fundamental step for improving the curability of this kind of tumor. The purpose of this study is to define the role of OPN in the diagnosis of MPM by determining its prognostic and diagnostic value.
A group of 24 surgically staged MPM subjects was compared with a group of 31 subjects with nonmalignant pulmonary diseases, and with 37 healthy controls. Tumor tissue was analyzed for OPN by immunohistochemical tests, and plasma OPN levels were measured by an enzyme-linked immunosorbent assay.
Plasma OPN levels were not significantly higher in either of the patient groups compared with the control group. Immunohistochemical analysis revealed OPN staining of tumor cells in 21 of 24 MPMs. Receiver operating characteristic curve/area under the curve (ROC/AUC) analysis comparing the plasma OPN levels in the healthy group with those of MPM patients showed 40% sensitivity and 100% specificity at a cutoff value of 60.8 ng of OPN per milliliter (AUC 0.6).
Plasma OPN levels do not discriminate between chronic inflammatory and malignant lung diseases and staining intensity in MPM specimens does not correlate with OPN plasma levels. |
| doi_str_mv | 10.1177/172460080902400208 |
| format | Article |
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A group of 24 surgically staged MPM subjects was compared with a group of 31 subjects with nonmalignant pulmonary diseases, and with 37 healthy controls. Tumor tissue was analyzed for OPN by immunohistochemical tests, and plasma OPN levels were measured by an enzyme-linked immunosorbent assay.
Plasma OPN levels were not significantly higher in either of the patient groups compared with the control group. Immunohistochemical analysis revealed OPN staining of tumor cells in 21 of 24 MPMs. Receiver operating characteristic curve/area under the curve (ROC/AUC) analysis comparing the plasma OPN levels in the healthy group with those of MPM patients showed 40% sensitivity and 100% specificity at a cutoff value of 60.8 ng of OPN per milliliter (AUC 0.6).
Plasma OPN levels do not discriminate between chronic inflammatory and malignant lung diseases and staining intensity in MPM specimens does not correlate with OPN plasma levels.</description><identifier>ISSN: 0393-6155</identifier><identifier>EISSN: 1724-6008</identifier><identifier>DOI: 10.1177/172460080902400208</identifier><identifier>PMID: 19634115</identifier><language>eng</language><publisher>Milano: Wichtig</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Analytical, structural and metabolic biochemistry ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Disease Progression ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Lung Neoplasms - diagnosis ; Lung Neoplasms - metabolism ; Male ; Medical sciences ; Mesothelioma - diagnosis ; Mesothelioma - metabolism ; Middle Aged ; Molecular biophysics ; Neoplasm Metastasis ; Osteopontin - biosynthesis ; Pleural Neoplasms - diagnosis ; Pleural Neoplasms - metabolism ; Treatment Outcome</subject><ispartof>The International journal of biological markers, 2009-04, Vol.24 (2), p.112-117</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c305t-829116bdbf9c7f4802ca1fc2361f876e448c7361cf4156c974f4b69d955a0b913</citedby><cites>FETCH-LOGICAL-c305t-829116bdbf9c7f4802ca1fc2361f876e448c7361cf4156c974f4b69d955a0b913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22015316$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19634115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PALEARI, Laura</creatorcontrib><creatorcontrib>ROTOLO, Nicola</creatorcontrib><creatorcontrib>IMPERATORI, Andrea</creatorcontrib><creatorcontrib>PUZONE, Roberto</creatorcontrib><creatorcontrib>SESSA, Fausto</creatorcontrib><creatorcontrib>FRANZI, Francesca</creatorcontrib><creatorcontrib>MEACCI, Elisa</creatorcontrib><creatorcontrib>CAMPLESE, Pierpaolo</creatorcontrib><creatorcontrib>CESARIO, Alfredo</creatorcontrib><creatorcontrib>PAGANUZZI, Michela</creatorcontrib><title>Osteopontin is not a specific marker in malignant pleural mesothelioma</title><title>The International journal of biological markers</title><addtitle>Int J Biol Markers</addtitle><description>Osteopontin (OPN) is an integrin-binding protein recently shown to be related to tumorigenesis, progression and metastasis in different experimental models of malignancy. Malignant pleural mesothelioma (MPM) is a fatal disease in which the prognosis remains very poor and the knowledge of predictive factors for outcome is insufficient. The identification of new molecules involved in cancer initiation and development is a fundamental step for improving the curability of this kind of tumor. The purpose of this study is to define the role of OPN in the diagnosis of MPM by determining its prognostic and diagnostic value.
A group of 24 surgically staged MPM subjects was compared with a group of 31 subjects with nonmalignant pulmonary diseases, and with 37 healthy controls. Tumor tissue was analyzed for OPN by immunohistochemical tests, and plasma OPN levels were measured by an enzyme-linked immunosorbent assay.
Plasma OPN levels were not significantly higher in either of the patient groups compared with the control group. Immunohistochemical analysis revealed OPN staining of tumor cells in 21 of 24 MPMs. Receiver operating characteristic curve/area under the curve (ROC/AUC) analysis comparing the plasma OPN levels in the healthy group with those of MPM patients showed 40% sensitivity and 100% specificity at a cutoff value of 60.8 ng of OPN per milliliter (AUC 0.6).
Plasma OPN levels do not discriminate between chronic inflammatory and malignant lung diseases and staining intensity in MPM specimens does not correlate with OPN plasma levels.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mesothelioma - diagnosis</subject><subject>Mesothelioma - metabolism</subject><subject>Middle Aged</subject><subject>Molecular biophysics</subject><subject>Neoplasm Metastasis</subject><subject>Osteopontin - biosynthesis</subject><subject>Pleural Neoplasms - diagnosis</subject><subject>Pleural Neoplasms - metabolism</subject><subject>Treatment Outcome</subject><issn>0393-6155</issn><issn>1724-6008</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkD9PwzAQxS0EoqXwBRhQFtgCPsd_4hFVFJAqdYE5clwbDE4c7GTg2-OqFQxMp3v3e0-6h9Al4FsAIe5AEMoxrrHEhGJMcH2E5jux3KnHaI4rWZUcGJuhs5Q-MgJY8FM0A8krCsDmaLVJowlD6EfXFy4VfRgLVaTBaGedLjoVP00s8q1T3r31qh-LwZspKl90JoXx3XgXOnWOTqzyyVwc5gK9rh5elk_levP4vLxfl7rCbCxrIgF4u22t1MLSGhOtwGpScbC14IbSWou8aEuBcS0FtbTlcisZU7iVUC3QzT53iOFrMmlsOpe08V71Jkyp4YIRzkmdQbIHdQwpRWObIbr8zXcDuNm11_xvL5uuDulT25ntn-VQVwauD4BKWnkbVa9d-uUIwRkCXv0AN5R2DA</recordid><startdate>20090401</startdate><enddate>20090401</enddate><creator>PALEARI, Laura</creator><creator>ROTOLO, Nicola</creator><creator>IMPERATORI, Andrea</creator><creator>PUZONE, Roberto</creator><creator>SESSA, Fausto</creator><creator>FRANZI, Francesca</creator><creator>MEACCI, Elisa</creator><creator>CAMPLESE, Pierpaolo</creator><creator>CESARIO, Alfredo</creator><creator>PAGANUZZI, Michela</creator><general>Wichtig</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090401</creationdate><title>Osteopontin is not a specific marker in malignant pleural mesothelioma</title><author>PALEARI, Laura ; ROTOLO, Nicola ; IMPERATORI, Andrea ; PUZONE, Roberto ; SESSA, Fausto ; FRANZI, Francesca ; MEACCI, Elisa ; CAMPLESE, Pierpaolo ; CESARIO, Alfredo ; PAGANUZZI, Michela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-829116bdbf9c7f4802ca1fc2361f876e448c7361cf4156c974f4b69d955a0b913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Lung Neoplasms - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mesothelioma - diagnosis</topic><topic>Mesothelioma - metabolism</topic><topic>Middle Aged</topic><topic>Molecular biophysics</topic><topic>Neoplasm Metastasis</topic><topic>Osteopontin - biosynthesis</topic><topic>Pleural Neoplasms - diagnosis</topic><topic>Pleural Neoplasms - metabolism</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PALEARI, Laura</creatorcontrib><creatorcontrib>ROTOLO, Nicola</creatorcontrib><creatorcontrib>IMPERATORI, Andrea</creatorcontrib><creatorcontrib>PUZONE, Roberto</creatorcontrib><creatorcontrib>SESSA, Fausto</creatorcontrib><creatorcontrib>FRANZI, Francesca</creatorcontrib><creatorcontrib>MEACCI, Elisa</creatorcontrib><creatorcontrib>CAMPLESE, Pierpaolo</creatorcontrib><creatorcontrib>CESARIO, Alfredo</creatorcontrib><creatorcontrib>PAGANUZZI, Michela</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The International journal of biological markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PALEARI, Laura</au><au>ROTOLO, Nicola</au><au>IMPERATORI, Andrea</au><au>PUZONE, Roberto</au><au>SESSA, Fausto</au><au>FRANZI, Francesca</au><au>MEACCI, Elisa</au><au>CAMPLESE, Pierpaolo</au><au>CESARIO, Alfredo</au><au>PAGANUZZI, Michela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Osteopontin is not a specific marker in malignant pleural mesothelioma</atitle><jtitle>The International journal of biological markers</jtitle><addtitle>Int J Biol Markers</addtitle><date>2009-04-01</date><risdate>2009</risdate><volume>24</volume><issue>2</issue><spage>112</spage><epage>117</epage><pages>112-117</pages><issn>0393-6155</issn><eissn>1724-6008</eissn><abstract>Osteopontin (OPN) is an integrin-binding protein recently shown to be related to tumorigenesis, progression and metastasis in different experimental models of malignancy. Malignant pleural mesothelioma (MPM) is a fatal disease in which the prognosis remains very poor and the knowledge of predictive factors for outcome is insufficient. The identification of new molecules involved in cancer initiation and development is a fundamental step for improving the curability of this kind of tumor. The purpose of this study is to define the role of OPN in the diagnosis of MPM by determining its prognostic and diagnostic value.
A group of 24 surgically staged MPM subjects was compared with a group of 31 subjects with nonmalignant pulmonary diseases, and with 37 healthy controls. Tumor tissue was analyzed for OPN by immunohistochemical tests, and plasma OPN levels were measured by an enzyme-linked immunosorbent assay.
Plasma OPN levels were not significantly higher in either of the patient groups compared with the control group. Immunohistochemical analysis revealed OPN staining of tumor cells in 21 of 24 MPMs. Receiver operating characteristic curve/area under the curve (ROC/AUC) analysis comparing the plasma OPN levels in the healthy group with those of MPM patients showed 40% sensitivity and 100% specificity at a cutoff value of 60.8 ng of OPN per milliliter (AUC 0.6).
Plasma OPN levels do not discriminate between chronic inflammatory and malignant lung diseases and staining intensity in MPM specimens does not correlate with OPN plasma levels.</abstract><cop>Milano</cop><pub>Wichtig</pub><pmid>19634115</pmid><doi>10.1177/172460080902400208</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The International journal of biological markers, 2009-04, Vol.24 (2), p.112-117 |
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| source | MEDLINE; Sage Journals GOLD Open Access 2024; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Aged, 80 and over Analytical, structural and metabolic biochemistry Biological and medical sciences Biomarkers, Tumor - metabolism Disease Progression Female Fundamental and applied biological sciences. Psychology Humans Investigative techniques, diagnostic techniques (general aspects) Lung Neoplasms - diagnosis Lung Neoplasms - metabolism Male Medical sciences Mesothelioma - diagnosis Mesothelioma - metabolism Middle Aged Molecular biophysics Neoplasm Metastasis Osteopontin - biosynthesis Pleural Neoplasms - diagnosis Pleural Neoplasms - metabolism Treatment Outcome |
| title | Osteopontin is not a specific marker in malignant pleural mesothelioma |
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