Pyrazolyl Derivatives as Bifunctional Chelators for Labeling Tumor-Seeking Peptides with the fac-[M(CO)3]+ Moiety (M = 99mTc, Re):  Synthesis, Characterization, and Biological Behavior

Radiolabeling of biologically active molecules with the [99mTc(CO)3]+ unit has been of primary interest in recent years. With this in mind, we herein report symmetric ( L 1 ) and asymmetric ( L 2 − L 5 ) pyrazolyl-containing chelators that have been evaluated in radiochemical reactions with the synt...

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Veröffentlicht in:Bioconjugate chemistry 2005-03, Vol.16 (2), p.438-449
Hauptverfasser: Alves, Susana, Paulo, António, Correia, João D. G, Gano, Lurdes, Smith, Charles J, Hoffman, Timothy J, Santos, Isabel
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Sprache:eng
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