Overexpression of beta2-adrenergic receptors in mouse liver alters the expression of gluconeogenic and glycolytic enzymes

In the livers of humans and many other mammalian species, beta2-adrenergic receptors (beta2-ARs) play an important role in the modulation of glucose production by glycogenolysis and gluconeogenesis. In male mice and rats, however, the expression and physiological role of hepatic beta2-ARs are rapidl...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2005-04, Vol.288 (4), p.E715-E722
Hauptverfasser:	Erraji-Benchekroun, Loubna, Couton, Dominique, Postic, Catherine, Borde, Isabelle, Gaston, Jesintha, Guillet, Jean-Gérard, André, Claudine
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - biosynthesis Adrenergic beta-Agonists - pharmacology Adrenergic beta-Antagonists - pharmacology Animals Binding, Competitive - physiology Blotting, Northern Clenbuterol - pharmacology Eating - physiology Glucose-6-Phosphatase - biosynthesis Glucose-6-Phosphatase - metabolism Glycogen - metabolism Liver - drug effects Liver - enzymology Liver - metabolism Male Mice Mice, Inbred C57BL Mice, Transgenic Phosphoenolpyruvate Carboxykinase (ATP) - biosynthesis Phosphoenolpyruvate Carboxykinase (ATP) - metabolism Propranolol - pharmacology Pyruvate Kinase - biosynthesis Pyruvate Kinase - metabolism Receptors, Adrenergic, beta-2 - biosynthesis Receptors, Adrenergic, beta-2 - genetics Receptors, Adrenergic, beta-2 - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis RNA, Messenger - genetics
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