Kruppel-Like Factor 2 (KLF2) Regulates Endothelial Thrombotic Function

The vascular endothelium maintains blood fluidity by inhibiting blood coagulation, inhibiting platelet aggregation, and promoting fibrinolysis. Endothelial cells lose these nonthrombogenic properties on exposure to proinflammatory stimuli. We recently identified the Kruppel-like factor KLF2 as a nov...

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Veröffentlicht in:	Circulation research 2005-03, Vol.96 (5), p.e48-e57
Hauptverfasser:	Lin, Zhiyong, Kumar, Ajay, SenBanerjee, Sucharita, Staniszewski, Kristine, Parmar, Kush, Vaughan, Douglas E, Gimbrone, Michael A, Balasubramanian, Viji, García-Cardeña, Guillermo, Jain, Mukesh K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta Binding Sites Blood Coagulation - genetics Blood Coagulation - physiology Cattle Cells, Cultured - metabolism DNA, Complementary - genetics Endothelial Cells - metabolism Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Hemorheology Humans Interleukin-1 - pharmacology Kruppel-Like Transcription Factors Nitric Oxide Synthase - biosynthesis Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type III Plasminogen Activator Inhibitor 1 - biosynthesis Plasminogen Activator Inhibitor 1 - genetics Promoter Regions, Genetic Recombinant Fusion Proteins - physiology RNA, Messenger - biosynthesis RNA, Messenger - genetics RNA, Small Interfering - pharmacology Thrombin - pharmacology Thrombomodulin - biosynthesis Thrombomodulin - genetics Thromboplastin - metabolism Thrombosis - metabolism Trans-Activators - biosynthesis Trans-Activators - genetics Trans-Activators - physiology Transcription, Genetic - physiology Transfection Tumor Necrosis Factor-alpha - pharmacology Umbilical Veins von Willebrand Factor - biosynthesis von Willebrand Factor - genetics
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