IgG4-related interstitial lung disease: a new and evolving concept
PURPOSE OF REVIEWThis review examines recent advances in our knowledge of the clinical, pathological, diagnostic, and therapeutic aspects of IgG4-related interstitial lung disease (ILD). RECENT FINDINGSA recent case series of ILD with IgG4-positive plasma cells suggested grade 1 lymphomatoid granulo...
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| Veröffentlicht in: | Current opinion in pulmonary medicine 2009-09, Vol.15 (5), p.513-516 |
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| creator | Shigemitsu, Hidenobu Koss, Michael N |
| description | PURPOSE OF REVIEWThis review examines recent advances in our knowledge of the clinical, pathological, diagnostic, and therapeutic aspects of IgG4-related interstitial lung disease (ILD).
RECENT FINDINGSA recent case series of ILD with IgG4-positive plasma cells suggested grade 1 lymphomatoid granulomatosis. The presence of the IgG4-positive plasma cells with the lack of atypical cells favored IgG4-related ILD as a diagnosis. In another case study, four out of 30 patients with autoimmune pancreatitis developed pulmonary involvement during follow-up. Elevations of IgG4 and Krebs von den Lungen-6 levels were associated and thought to be predictive of the development of IgG4-related lung disease. A retrospective analysis investigating radiological/pathologic correlation in IgG4 lung disease identified computed tomographic features pathologically corresponding to IgG4-related sclerosing inflammation in the pulmonary interstitium.
SUMMARYIgG4-related ILD is a new and evolving entity. It can occur with or without systemic involvement. Larger studies are necessary to elucidate the exact mechanism and clinical characteristics of this disorder. |
| doi_str_mv | 10.1097/MCP.0b013e32832ea509 |
| format | Article |
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RECENT FINDINGSA recent case series of ILD with IgG4-positive plasma cells suggested grade 1 lymphomatoid granulomatosis. The presence of the IgG4-positive plasma cells with the lack of atypical cells favored IgG4-related ILD as a diagnosis. In another case study, four out of 30 patients with autoimmune pancreatitis developed pulmonary involvement during follow-up. Elevations of IgG4 and Krebs von den Lungen-6 levels were associated and thought to be predictive of the development of IgG4-related lung disease. A retrospective analysis investigating radiological/pathologic correlation in IgG4 lung disease identified computed tomographic features pathologically corresponding to IgG4-related sclerosing inflammation in the pulmonary interstitium.
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RECENT FINDINGSA recent case series of ILD with IgG4-positive plasma cells suggested grade 1 lymphomatoid granulomatosis. The presence of the IgG4-positive plasma cells with the lack of atypical cells favored IgG4-related ILD as a diagnosis. In another case study, four out of 30 patients with autoimmune pancreatitis developed pulmonary involvement during follow-up. Elevations of IgG4 and Krebs von den Lungen-6 levels were associated and thought to be predictive of the development of IgG4-related lung disease. A retrospective analysis investigating radiological/pathologic correlation in IgG4 lung disease identified computed tomographic features pathologically corresponding to IgG4-related sclerosing inflammation in the pulmonary interstitium.
SUMMARYIgG4-related ILD is a new and evolving entity. It can occur with or without systemic involvement. Larger studies are necessary to elucidate the exact mechanism and clinical characteristics of this disorder.</description><subject>Antibodies, Anti-Idiotypic - immunology</subject><subject>Autoimmunity - immunology</subject><subject>Diagnosis, Differential</subject><subject>Humans</subject><subject>Immunoglobulin G - immunology</subject><subject>Immunoglobulin G - metabolism</subject><subject>Lung Diseases, Interstitial - diagnosis</subject><subject>Lung Diseases, Interstitial - immunology</subject><subject>Lung Diseases, Interstitial - metabolism</subject><issn>1070-5287</issn><issn>1531-6971</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLFOwzAURS0EoqXwBwhlYkvxc-w4ZoMKSqUiGGC2HPulDbhJiZNW_D2pWgmJgeld6Z17h0PIJdAxUCVvnievY5pTSDBhWcLQCKqOyBBEAnGqJBz3mUoaC5bJATkL4YNSYArglAxACUH72pDczxZTHjfoTYsuKqsWm9CWbWl85LtqEbkyoAl4G5mowm1kKhfhpvabsv_ZurK4bs_JSWF8wIvDHZH3x4e3yVM8f5nOJnfz2HJGVQwgC8oYA2sYOAcAgicpV7lQUHDHM6kyITPMDbiscMymIi8yK1JjRaFUnozI9X533dRfHYZWr8pg0XtTYd0FnUrBuOTQg3wP2qYOocFCr5tyZZpvDVTv3Onenf7rrq9dHfa7fIXut3SQ1QPZHtjWfufp03dbbPQSjW-X_2__AGKRfAo</recordid><startdate>200909</startdate><enddate>200909</enddate><creator>Shigemitsu, Hidenobu</creator><creator>Koss, Michael N</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200909</creationdate><title>IgG4-related interstitial lung disease: a new and evolving concept</title><author>Shigemitsu, Hidenobu ; Koss, Michael N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4209-117f02221ca21dd111543649b591f4d48798578eba1d8fd2c65bf8c56ac5f99b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Antibodies, Anti-Idiotypic - immunology</topic><topic>Autoimmunity - immunology</topic><topic>Diagnosis, Differential</topic><topic>Humans</topic><topic>Immunoglobulin G - immunology</topic><topic>Immunoglobulin G - metabolism</topic><topic>Lung Diseases, Interstitial - diagnosis</topic><topic>Lung Diseases, Interstitial - immunology</topic><topic>Lung Diseases, Interstitial - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Shigemitsu, Hidenobu</creatorcontrib><creatorcontrib>Koss, Michael N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current opinion in pulmonary medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shigemitsu, Hidenobu</au><au>Koss, Michael N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IgG4-related interstitial lung disease: a new and evolving concept</atitle><jtitle>Current opinion in pulmonary medicine</jtitle><addtitle>Curr Opin Pulm Med</addtitle><date>2009-09</date><risdate>2009</risdate><volume>15</volume><issue>5</issue><spage>513</spage><epage>516</epage><pages>513-516</pages><issn>1070-5287</issn><eissn>1531-6971</eissn><abstract>PURPOSE OF REVIEWThis review examines recent advances in our knowledge of the clinical, pathological, diagnostic, and therapeutic aspects of IgG4-related interstitial lung disease (ILD).
RECENT FINDINGSA recent case series of ILD with IgG4-positive plasma cells suggested grade 1 lymphomatoid granulomatosis. The presence of the IgG4-positive plasma cells with the lack of atypical cells favored IgG4-related ILD as a diagnosis. In another case study, four out of 30 patients with autoimmune pancreatitis developed pulmonary involvement during follow-up. Elevations of IgG4 and Krebs von den Lungen-6 levels were associated and thought to be predictive of the development of IgG4-related lung disease. A retrospective analysis investigating radiological/pathologic correlation in IgG4 lung disease identified computed tomographic features pathologically corresponding to IgG4-related sclerosing inflammation in the pulmonary interstitium.
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| ispartof | Current opinion in pulmonary medicine, 2009-09, Vol.15 (5), p.513-516 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Antibodies, Anti-Idiotypic - immunology Autoimmunity - immunology Diagnosis, Differential Humans Immunoglobulin G - immunology Immunoglobulin G - metabolism Lung Diseases, Interstitial - diagnosis Lung Diseases, Interstitial - immunology Lung Diseases, Interstitial - metabolism |
| title | IgG4-related interstitial lung disease: a new and evolving concept |
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