Plasma Nociceptin Levels are Reduced in Migraine without Aura
It was demonstrated that both nociceptin, a novel opioid neuropeptide, and its receptor are present in trigeminovascular neurons. In an animal model nociceptin dose-dependently inhibited neurogenic dural vasodilatation. These results suggest that nociceptin may be involved in neurovascular headaches...
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| Veröffentlicht in: | Cephalalgia 2005-04, Vol.25 (4), p.261-266 |
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| creator | Ertsey, C Hantos, M Bozsik, G Tekes, K |
| description | It was demonstrated that both nociceptin, a novel opioid neuropeptide, and its receptor are present in trigeminovascular neurons. In an animal model nociceptin dose-dependently inhibited neurogenic dural vasodilatation. These results suggest that nociceptin may be involved in neurovascular headaches such as migraine. To test this hypothesis, we studied circulating nociceptin levels in 18 patients suffering from migraine without aura and in 24 controls. Headache-free migraineurs had significantly lower nociceptin levels than controls (5.79 ± 1.82 vs. 9.74 ± 2.43 pg/ml, P < 0.0001, Student's t-tests). Nociceptin levels were further reduced in six patients studied in the first 3 h of typical migraine attacks (1.04 ± 0.17 pg/ml). Nociceptin levels correlated with the frequency of attacks in this group of migraineurs. Lower interictal nociceptin levels may contribute to a defective regulation of trigeminovascular neurons in migraineurs which might be important in the pain process of migraine. |
| doi_str_mv | 10.1111/j.1468-2982.2004.00849.x |
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In an animal model nociceptin dose-dependently inhibited neurogenic dural vasodilatation. These results suggest that nociceptin may be involved in neurovascular headaches such as migraine. To test this hypothesis, we studied circulating nociceptin levels in 18 patients suffering from migraine without aura and in 24 controls. Headache-free migraineurs had significantly lower nociceptin levels than controls (5.79 ± 1.82 vs. 9.74 ± 2.43 pg/ml, P < 0.0001, Student's t-tests). Nociceptin levels were further reduced in six patients studied in the first 3 h of typical migraine attacks (1.04 ± 0.17 pg/ml). Nociceptin levels correlated with the frequency of attacks in this group of migraineurs. 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In an animal model nociceptin dose-dependently inhibited neurogenic dural vasodilatation. These results suggest that nociceptin may be involved in neurovascular headaches such as migraine. To test this hypothesis, we studied circulating nociceptin levels in 18 patients suffering from migraine without aura and in 24 controls. Headache-free migraineurs had significantly lower nociceptin levels than controls (5.79 ± 1.82 vs. 9.74 ± 2.43 pg/ml, P < 0.0001, Student's t-tests). Nociceptin levels were further reduced in six patients studied in the first 3 h of typical migraine attacks (1.04 ± 0.17 pg/ml). Nociceptin levels correlated with the frequency of attacks in this group of migraineurs. Lower interictal nociceptin levels may contribute to a defective regulation of trigeminovascular neurons in migraineurs which might be important in the pain process of migraine.</description><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Female</subject><subject>Human</subject><subject>Humans</subject><subject>Male</subject><subject>Migraine</subject><subject>Migraine without Aura - blood</subject><subject>Migraine without Aura - diagnosis</subject><subject>Nociceptin</subject><subject>Opioid Peptides - blood</subject><subject>OP‐4 receptor</subject><subject>Risk Assessment - methods</subject><subject>Risk Factors</subject><subject>Statistics as Topic</subject><subject>Trigeminovascular system</subject><issn>0333-1024</issn><issn>1468-2982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM9PwjAUxxujEUT_BbOTt83-WtsdOBCCYoJKjJ6bsr3hlrFhywT-ezshetRe2rx-vu-9fBAKCI6IP7dlRLhQIU0UjSjGPMJY8STanaD-z8cp6mPGWEgw5T104VyJMY4FFueoR2IpmaKsj4bzyriVCZ6atEhhvSnqYAafULnAWAheIGtTyAJffSyW1hQ1BNti8960m2DUWnOJznJTObg63gP0djd5HU_D2fP9w3g0C1NOWBJmSSKFwlwQylKTcAoqhkyyXEqZ8ywWFPIMVM4VNUlGEibUArihUokF8QQboJtD37VtPlpwG70qXApVZWpoWqeFjCljXHhQHcDUNs5ZyPXaFitj95pg3anTpe4M6c6Q7tTpb3V656PXxxntYgXZb_DoygPDA7AtKtj_u7EeT-ZT__L5-JB3Zgm6bFpbe2d_L_YFwOyLUg</recordid><startdate>200504</startdate><enddate>200504</enddate><creator>Ertsey, C</creator><creator>Hantos, M</creator><creator>Bozsik, G</creator><creator>Tekes, K</creator><general>SAGE Publications</general><general>Blackwell Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200504</creationdate><title>Plasma Nociceptin Levels are Reduced in Migraine without Aura</title><author>Ertsey, C ; Hantos, M ; Bozsik, G ; Tekes, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4139-d99768046123ca942e85ed73f777f4d562efde8f482a9d19368be4a2786b17f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Female</topic><topic>Human</topic><topic>Humans</topic><topic>Male</topic><topic>Migraine</topic><topic>Migraine without Aura - blood</topic><topic>Migraine without Aura - diagnosis</topic><topic>Nociceptin</topic><topic>Opioid Peptides - blood</topic><topic>OP‐4 receptor</topic><topic>Risk Assessment - methods</topic><topic>Risk Factors</topic><topic>Statistics as Topic</topic><topic>Trigeminovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ertsey, C</creatorcontrib><creatorcontrib>Hantos, M</creatorcontrib><creatorcontrib>Bozsik, G</creatorcontrib><creatorcontrib>Tekes, K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cephalalgia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Ertsey, C</au><au>Hantos, M</au><au>Bozsik, G</au><au>Tekes, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma Nociceptin Levels are Reduced in Migraine without Aura</atitle><jtitle>Cephalalgia</jtitle><addtitle>Cephalalgia</addtitle><date>2005-04</date><risdate>2005</risdate><volume>25</volume><issue>4</issue><spage>261</spage><epage>266</epage><pages>261-266</pages><issn>0333-1024</issn><eissn>1468-2982</eissn><abstract>It was demonstrated that both nociceptin, a novel opioid neuropeptide, and its receptor are present in trigeminovascular neurons. In an animal model nociceptin dose-dependently inhibited neurogenic dural vasodilatation. These results suggest that nociceptin may be involved in neurovascular headaches such as migraine. To test this hypothesis, we studied circulating nociceptin levels in 18 patients suffering from migraine without aura and in 24 controls. Headache-free migraineurs had significantly lower nociceptin levels than controls (5.79 ± 1.82 vs. 9.74 ± 2.43 pg/ml, P < 0.0001, Student's t-tests). Nociceptin levels were further reduced in six patients studied in the first 3 h of typical migraine attacks (1.04 ± 0.17 pg/ml). Nociceptin levels correlated with the frequency of attacks in this group of migraineurs. Lower interictal nociceptin levels may contribute to a defective regulation of trigeminovascular neurons in migraineurs which might be important in the pain process of migraine.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>15773823</pmid><doi>10.1111/j.1468-2982.2004.00849.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | Cephalalgia, 2005-04, Vol.25 (4), p.261-266 |
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| language | eng |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Adult Biomarkers - blood Female Human Humans Male Migraine Migraine without Aura - blood Migraine without Aura - diagnosis Nociceptin Opioid Peptides - blood OP‐4 receptor Risk Assessment - methods Risk Factors Statistics as Topic Trigeminovascular system |
| title | Plasma Nociceptin Levels are Reduced in Migraine without Aura |
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