Dopamine dysregulation syndrome, impulse control disorders and punding after deep brain stimulation surgery for Parkinson’s disease
Abstract Data regarding the effect of deep brain stimulation (DBS) surgery on the dopamine dysregulation syndrome (DDS), impulse control disorders (ICDs) and punding in Parkinson’s disease (PD) are limited. We present a case series of 21 operated PD patients who had exhibited DDS, ICDs or punding at...
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| Veröffentlicht in: | Journal of clinical neuroscience 2009-09, Vol.16 (9), p.1148-1152 |
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| creator | Lim, Shen-Yang O’Sullivan, Sean S Kotschet, Katya Gallagher, David A Lacey, Cameron Lawrence, Andrew D Lees, Andrew J O’Sullivan, Dudley J Peppard, Richard F Rodrigues, Julian P Schrag, Anette Silberstein, Paul Tisch, Stephen Evans, Andrew H |
| description | Abstract Data regarding the effect of deep brain stimulation (DBS) surgery on the dopamine dysregulation syndrome (DDS), impulse control disorders (ICDs) and punding in Parkinson’s disease (PD) are limited. We present a case series of 21 operated PD patients who had exhibited DDS, ICDs or punding at some stage during the disease. DDS remained unimproved or worsened post-operatively in 12/17 patients with pre-operative DDS (71%) (nine bilateral subthalamic nucleus [STN], one right-sided STN, two bilateral globus pallidus internus [GPi] DBS). DDS improved or resolved after bilateral STN DBS in 5/17 patients with pre-operative DDS. DDS apparently developed for the first time after bilateral STN DBS in two patients, although only after a latency of eight years in one case. One patient without reported pre-operative DDS or ICDs developed pathological gambling post-STN DBS. One patient had pathological gambling which resolved pre-operatively, and did not recur post-DBS. Thus, DDS, ICDs and punding may persist, worsen or develop for the first time after DBS surgery, although a minority of patients improved dramatically. Predictive factors may include physician vigilance, motor outcome and patient compliance. |
| doi_str_mv | 10.1016/j.jocn.2008.12.010 |
| format | Article |
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We present a case series of 21 operated PD patients who had exhibited DDS, ICDs or punding at some stage during the disease. DDS remained unimproved or worsened post-operatively in 12/17 patients with pre-operative DDS (71%) (nine bilateral subthalamic nucleus [STN], one right-sided STN, two bilateral globus pallidus internus [GPi] DBS). DDS improved or resolved after bilateral STN DBS in 5/17 patients with pre-operative DDS. DDS apparently developed for the first time after bilateral STN DBS in two patients, although only after a latency of eight years in one case. One patient without reported pre-operative DDS or ICDs developed pathological gambling post-STN DBS. One patient had pathological gambling which resolved pre-operatively, and did not recur post-DBS. Thus, DDS, ICDs and punding may persist, worsen or develop for the first time after DBS surgery, although a minority of patients improved dramatically. Predictive factors may include physician vigilance, motor outcome and patient compliance.</description><identifier>ISSN: 0967-5868</identifier><identifier>EISSN: 1532-2653</identifier><identifier>DOI: 10.1016/j.jocn.2008.12.010</identifier><identifier>PMID: 19553125</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Deep Brain Stimulation - adverse effects ; Deep brain stimulation surgery ; Disruptive, Impulse Control, and Conduct Disorders - etiology ; Disruptive, Impulse Control, and Conduct Disorders - psychology ; Dopamine - metabolism ; Dopamine - physiology ; Dopamine dysregulation syndrome ; Female ; Health Care Surveys ; Humans ; Impulse control disorders ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Movement Disorders - etiology ; Movement Disorders - psychology ; Neurology ; Neurosurgical Procedures - adverse effects ; Parkinson Disease - complications ; Parkinson Disease - psychology ; Parkinson Disease - surgery ; Parkinson’s disease ; Patient Compliance ; Postoperative Complications - psychology ; Punding ; Subthalamic nucleus ; Surveys and Questionnaires ; Treatment Outcome ; Young Adult</subject><ispartof>Journal of clinical neuroscience, 2009-09, Vol.16 (9), p.1148-1152</ispartof><rights>Elsevier Ltd</rights><rights>2009 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-662c6f2f6f4d5c14bafe850320a3e80cfecf7576875473f326b279c77916a2863</citedby><cites>FETCH-LOGICAL-c440t-662c6f2f6f4d5c14bafe850320a3e80cfecf7576875473f326b279c77916a2863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jocn.2008.12.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19553125$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lim, Shen-Yang</creatorcontrib><creatorcontrib>O’Sullivan, Sean S</creatorcontrib><creatorcontrib>Kotschet, Katya</creatorcontrib><creatorcontrib>Gallagher, David A</creatorcontrib><creatorcontrib>Lacey, Cameron</creatorcontrib><creatorcontrib>Lawrence, Andrew D</creatorcontrib><creatorcontrib>Lees, Andrew J</creatorcontrib><creatorcontrib>O’Sullivan, Dudley J</creatorcontrib><creatorcontrib>Peppard, Richard F</creatorcontrib><creatorcontrib>Rodrigues, Julian P</creatorcontrib><creatorcontrib>Schrag, Anette</creatorcontrib><creatorcontrib>Silberstein, Paul</creatorcontrib><creatorcontrib>Tisch, Stephen</creatorcontrib><creatorcontrib>Evans, Andrew H</creatorcontrib><title>Dopamine dysregulation syndrome, impulse control disorders and punding after deep brain stimulation surgery for Parkinson’s disease</title><title>Journal of clinical neuroscience</title><addtitle>J Clin Neurosci</addtitle><description>Abstract Data regarding the effect of deep brain stimulation (DBS) surgery on the dopamine dysregulation syndrome (DDS), impulse control disorders (ICDs) and punding in Parkinson’s disease (PD) are limited. We present a case series of 21 operated PD patients who had exhibited DDS, ICDs or punding at some stage during the disease. DDS remained unimproved or worsened post-operatively in 12/17 patients with pre-operative DDS (71%) (nine bilateral subthalamic nucleus [STN], one right-sided STN, two bilateral globus pallidus internus [GPi] DBS). DDS improved or resolved after bilateral STN DBS in 5/17 patients with pre-operative DDS. DDS apparently developed for the first time after bilateral STN DBS in two patients, although only after a latency of eight years in one case. One patient without reported pre-operative DDS or ICDs developed pathological gambling post-STN DBS. One patient had pathological gambling which resolved pre-operatively, and did not recur post-DBS. Thus, DDS, ICDs and punding may persist, worsen or develop for the first time after DBS surgery, although a minority of patients improved dramatically. Predictive factors may include physician vigilance, motor outcome and patient compliance.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Deep Brain Stimulation - adverse effects</subject><subject>Deep brain stimulation surgery</subject><subject>Disruptive, Impulse Control, and Conduct Disorders - etiology</subject><subject>Disruptive, Impulse Control, and Conduct Disorders - psychology</subject><subject>Dopamine - metabolism</subject><subject>Dopamine - physiology</subject><subject>Dopamine dysregulation syndrome</subject><subject>Female</subject><subject>Health Care Surveys</subject><subject>Humans</subject><subject>Impulse control disorders</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Movement Disorders - etiology</subject><subject>Movement Disorders - psychology</subject><subject>Neurology</subject><subject>Neurosurgical Procedures - adverse effects</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - psychology</subject><subject>Parkinson Disease - surgery</subject><subject>Parkinson’s disease</subject><subject>Patient Compliance</subject><subject>Postoperative Complications - psychology</subject><subject>Punding</subject><subject>Subthalamic nucleus</subject><subject>Surveys and Questionnaires</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0967-5868</issn><issn>1532-2653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks2q1TAUhYso3uPVF3AgGTmyNT9N0oIIcv2FCwrqOOQkO4ec2yY1aYXOnPgQvp5PYso5KDjQ0Z6s9W1Ya1XVQ4Ibgol4emyO0YSGYtw1hDaY4FvVjnBGayo4u13tcC9kzTvRXVT3cj5ijPuW4bvVBek5Z4TyXfX9ZZz06AMgu-YEh2XQs48B5TXYFEd4gvw4LUMGZGKYUxyQ9TkmCykjHSyalmB9OCDtZkjIAkxon7QvgNmPv2FLOkBakYsJfdDpxoccw89vP_IGA53hfnXH6fLkwfleVp9fv_p09ba-fv_m3dWL69q0LZ5rIagRjjrhWssNaffaQccxo1gz6LBxYJzkUnSSt5I5RsWeyt5I2ROhaSfYZfX4xJ1S_LJAntXos4Fh0AHikpWQnDLc0v8KKZYEd6wtQnoSmhRzCdCpKflRp1URrLaW1FFtLamtJUWoKi0V06MzfdmPYP9YzrUUwbOTAEoYXz0klY2HYMD6BGZWNvp_85__ZTeDD97o4QZWyMe4pFBiVkTlYlAft51sM8F9mYgQgv0C9Pe79g</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>Lim, Shen-Yang</creator><creator>O’Sullivan, Sean S</creator><creator>Kotschet, Katya</creator><creator>Gallagher, David A</creator><creator>Lacey, Cameron</creator><creator>Lawrence, Andrew D</creator><creator>Lees, Andrew J</creator><creator>O’Sullivan, Dudley J</creator><creator>Peppard, Richard F</creator><creator>Rodrigues, Julian P</creator><creator>Schrag, Anette</creator><creator>Silberstein, Paul</creator><creator>Tisch, Stephen</creator><creator>Evans, Andrew H</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20090901</creationdate><title>Dopamine dysregulation syndrome, impulse control disorders and punding after deep brain stimulation surgery for Parkinson’s disease</title><author>Lim, Shen-Yang ; O’Sullivan, Sean S ; Kotschet, Katya ; Gallagher, David A ; Lacey, Cameron ; Lawrence, Andrew D ; Lees, Andrew J ; O’Sullivan, Dudley J ; Peppard, Richard F ; Rodrigues, Julian P ; Schrag, Anette ; Silberstein, Paul ; Tisch, Stephen ; Evans, Andrew H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-662c6f2f6f4d5c14bafe850320a3e80cfecf7576875473f326b279c77916a2863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Deep Brain Stimulation - adverse effects</topic><topic>Deep brain stimulation surgery</topic><topic>Disruptive, Impulse Control, and Conduct Disorders - etiology</topic><topic>Disruptive, Impulse Control, and Conduct Disorders - psychology</topic><topic>Dopamine - metabolism</topic><topic>Dopamine - physiology</topic><topic>Dopamine dysregulation syndrome</topic><topic>Female</topic><topic>Health Care Surveys</topic><topic>Humans</topic><topic>Impulse control disorders</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Movement Disorders - etiology</topic><topic>Movement Disorders - psychology</topic><topic>Neurology</topic><topic>Neurosurgical Procedures - adverse effects</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson Disease - psychology</topic><topic>Parkinson Disease - surgery</topic><topic>Parkinson’s disease</topic><topic>Patient Compliance</topic><topic>Postoperative Complications - psychology</topic><topic>Punding</topic><topic>Subthalamic nucleus</topic><topic>Surveys and Questionnaires</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lim, Shen-Yang</creatorcontrib><creatorcontrib>O’Sullivan, Sean S</creatorcontrib><creatorcontrib>Kotschet, Katya</creatorcontrib><creatorcontrib>Gallagher, David A</creatorcontrib><creatorcontrib>Lacey, Cameron</creatorcontrib><creatorcontrib>Lawrence, Andrew D</creatorcontrib><creatorcontrib>Lees, Andrew J</creatorcontrib><creatorcontrib>O’Sullivan, Dudley J</creatorcontrib><creatorcontrib>Peppard, Richard F</creatorcontrib><creatorcontrib>Rodrigues, Julian P</creatorcontrib><creatorcontrib>Schrag, Anette</creatorcontrib><creatorcontrib>Silberstein, Paul</creatorcontrib><creatorcontrib>Tisch, Stephen</creatorcontrib><creatorcontrib>Evans, Andrew H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lim, Shen-Yang</au><au>O’Sullivan, Sean S</au><au>Kotschet, Katya</au><au>Gallagher, David A</au><au>Lacey, Cameron</au><au>Lawrence, Andrew D</au><au>Lees, Andrew J</au><au>O’Sullivan, Dudley J</au><au>Peppard, Richard F</au><au>Rodrigues, Julian P</au><au>Schrag, Anette</au><au>Silberstein, Paul</au><au>Tisch, Stephen</au><au>Evans, Andrew H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dopamine dysregulation syndrome, impulse control disorders and punding after deep brain stimulation surgery for Parkinson’s disease</atitle><jtitle>Journal of clinical neuroscience</jtitle><addtitle>J Clin Neurosci</addtitle><date>2009-09-01</date><risdate>2009</risdate><volume>16</volume><issue>9</issue><spage>1148</spage><epage>1152</epage><pages>1148-1152</pages><issn>0967-5868</issn><eissn>1532-2653</eissn><abstract>Abstract Data regarding the effect of deep brain stimulation (DBS) surgery on the dopamine dysregulation syndrome (DDS), impulse control disorders (ICDs) and punding in Parkinson’s disease (PD) are limited. We present a case series of 21 operated PD patients who had exhibited DDS, ICDs or punding at some stage during the disease. DDS remained unimproved or worsened post-operatively in 12/17 patients with pre-operative DDS (71%) (nine bilateral subthalamic nucleus [STN], one right-sided STN, two bilateral globus pallidus internus [GPi] DBS). DDS improved or resolved after bilateral STN DBS in 5/17 patients with pre-operative DDS. DDS apparently developed for the first time after bilateral STN DBS in two patients, although only after a latency of eight years in one case. One patient without reported pre-operative DDS or ICDs developed pathological gambling post-STN DBS. One patient had pathological gambling which resolved pre-operatively, and did not recur post-DBS. Thus, DDS, ICDs and punding may persist, worsen or develop for the first time after DBS surgery, although a minority of patients improved dramatically. Predictive factors may include physician vigilance, motor outcome and patient compliance.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>19553125</pmid><doi>10.1016/j.jocn.2008.12.010</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Deep Brain Stimulation - adverse effects Deep brain stimulation surgery Disruptive, Impulse Control, and Conduct Disorders - etiology Disruptive, Impulse Control, and Conduct Disorders - psychology Dopamine - metabolism Dopamine - physiology Dopamine dysregulation syndrome Female Health Care Surveys Humans Impulse control disorders Magnetic Resonance Imaging Male Middle Aged Movement Disorders - etiology Movement Disorders - psychology Neurology Neurosurgical Procedures - adverse effects Parkinson Disease - complications Parkinson Disease - psychology Parkinson Disease - surgery Parkinson’s disease Patient Compliance Postoperative Complications - psychology Punding Subthalamic nucleus Surveys and Questionnaires Treatment Outcome Young Adult |
| title | Dopamine dysregulation syndrome, impulse control disorders and punding after deep brain stimulation surgery for Parkinson’s disease |
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