A catheter based chronic porcine model of post-infarct dilated heart failure
Objectives. New surgical treatments for post-infarct antero-septal myocardial akinesia have been developed but evaluation of their mode of function is hampered by absence of suitable large animal heart failure models. We aimed to develop and evaluate a human compatible model for chronic post-infarct...
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| Veröffentlicht in: | Scandinavian cardiovascular journal : SCJ 2009-01, Vol.43 (4), p.260-266 |
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| creator | Brødløs, Hans Kristian Bramsen, Morten B. Agger, Peter Jensen, Henrik Bjerre, Marianne Ringgaard, Steffen Wierup, Per Nielsen, Sten Lyager Hasenkam, J. Michael Smerup, Morten |
| description | Objectives. New surgical treatments for post-infarct antero-septal myocardial akinesia have been developed but evaluation of their mode of function is hampered by absence of suitable large animal heart failure models. We aimed to develop and evaluate a human compatible model for chronic post-infarct left ventricular (LV) remodeling. Design. Fourteen female 50 kg pigs underwent catheter-based coronary artery occlusion (one hour) distal to the first LAD diagonal. Eight weight- and age-matched healthy animals served as controls. LV geometry and function were assessed after 6 weeks with cardiovascular MRI. Results. All animals recovered from interventions. Three animals died during follow-up. All intervention animals had antero-septal akinetic infarcts (mean 26.5% of LV myocardium). Intervention animals had significantly increased end-diastolic and end-systolic volumes, and decreased stroke volume, ejection fraction and cardiac output. Detailed functional analysis showed significant systolic- and diastolic-dysfunction in intervention animals. Conclusions. We have established a feasible model of post-infarct LV remodeling, which accurately simulates human pathogenesis and pathophysiology. The model may be suitable for evaluation of novel surgical alleviations for heart failure. |
| doi_str_mv | 10.1080/14017430802604034 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_67521365</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67521365</sourcerecordid><originalsourceid>FETCH-LOGICAL-c399t-592526a7cdd123503962ba6cd08c1c327458be73e5bb5a15ed9ca24b7420d49e3</originalsourceid><addsrcrecordid>eNp9kE1r3DAQhkVJaT7aH9BL8Ck3J_r2mvQSQr9gIZf2LMbSmHWQrc1IpuTfR2UXQinkNMPoeV_Ew9hnwa8F3_AbobnotKqrtFxzpd-xM2GNaCXn9qTu9b2tgDhl5zk_ci7MxogP7FT03BqtuzO2vWs8lB0WpGaAjKHxO0rL5Jt9Ij8t2MwpYGzSWA-5tNMyAvnShClCqfQOgUozwhRXwo_s_Qgx46fjvGC_v339df-j3T58_3l_t2296vvSml4aaaHzIQipDFe9lQNYH_jGC69kp81mwE6hGQYDwmDoPUg9dFryoHtUF-zq0Lun9LRiLm6esscYYcG0Zmc7I4WypoLiAHpKOROObk_TDPTsBHd_Fbr_FNbM5bF8HWYMr4mjswp8OQDVRaIZ_iSKwRV4jolGgsVP2am3-m__iVeDsew8ELrHtNJSxb3xuxcKD5Ab</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67521365</pqid></control><display><type>article</type><title>A catheter based chronic porcine model of post-infarct dilated heart failure</title><source>MEDLINE</source><source>Taylor & Francis Journals Complete</source><creator>Brødløs, Hans Kristian ; Bramsen, Morten B. ; Agger, Peter ; Jensen, Henrik ; Bjerre, Marianne ; Ringgaard, Steffen ; Wierup, Per ; Nielsen, Sten Lyager ; Hasenkam, J. Michael ; Smerup, Morten</creator><creatorcontrib>Brødløs, Hans Kristian ; Bramsen, Morten B. ; Agger, Peter ; Jensen, Henrik ; Bjerre, Marianne ; Ringgaard, Steffen ; Wierup, Per ; Nielsen, Sten Lyager ; Hasenkam, J. Michael ; Smerup, Morten</creatorcontrib><description>Objectives. New surgical treatments for post-infarct antero-septal myocardial akinesia have been developed but evaluation of their mode of function is hampered by absence of suitable large animal heart failure models. We aimed to develop and evaluate a human compatible model for chronic post-infarct left ventricular (LV) remodeling. Design. Fourteen female 50 kg pigs underwent catheter-based coronary artery occlusion (one hour) distal to the first LAD diagonal. Eight weight- and age-matched healthy animals served as controls. LV geometry and function were assessed after 6 weeks with cardiovascular MRI. Results. All animals recovered from interventions. Three animals died during follow-up. All intervention animals had antero-septal akinetic infarcts (mean 26.5% of LV myocardium). Intervention animals had significantly increased end-diastolic and end-systolic volumes, and decreased stroke volume, ejection fraction and cardiac output. Detailed functional analysis showed significant systolic- and diastolic-dysfunction in intervention animals. Conclusions. We have established a feasible model of post-infarct LV remodeling, which accurately simulates human pathogenesis and pathophysiology. The model may be suitable for evaluation of novel surgical alleviations for heart failure.</description><identifier>ISSN: 1401-7431</identifier><identifier>EISSN: 1651-2006</identifier><identifier>DOI: 10.1080/14017430802604034</identifier><identifier>PMID: 19065447</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Animals ; Cardiac Catheterization - adverse effects ; Cardiac Output ; Disease Models, Animal ; experimental models ; Feasibility Studies ; Female ; heart failure ; Heart Failure - etiology ; Heart Failure - pathology ; Heart Failure - physiopathology ; heart failure surgery ; Hypertrophy, Left Ventricular - etiology ; Hypertrophy, Left Ventricular - pathology ; Hypertrophy, Left Ventricular - physiopathology ; ischemic heart disease ; Left ventricle ; Magnetic Resonance Imaging ; Myocardial Infarction - complications ; Myocardial Infarction - etiology ; Myocardial Infarction - pathology ; Myocardial Infarction - physiopathology ; Myocardium - pathology ; Reproducibility of Results ; Stroke Volume ; Swine ; Time Factors ; Ventricular Dysfunction, Left - etiology ; Ventricular Dysfunction, Left - pathology ; Ventricular Dysfunction, Left - physiopathology ; Ventricular Remodeling</subject><ispartof>Scandinavian cardiovascular journal : SCJ, 2009-01, Vol.43 (4), p.260-266</ispartof><rights>2009 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c399t-592526a7cdd123503962ba6cd08c1c327458be73e5bb5a15ed9ca24b7420d49e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/14017430802604034$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/14017430802604034$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,59626,60415,61200,61381</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19065447$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brødløs, Hans Kristian</creatorcontrib><creatorcontrib>Bramsen, Morten B.</creatorcontrib><creatorcontrib>Agger, Peter</creatorcontrib><creatorcontrib>Jensen, Henrik</creatorcontrib><creatorcontrib>Bjerre, Marianne</creatorcontrib><creatorcontrib>Ringgaard, Steffen</creatorcontrib><creatorcontrib>Wierup, Per</creatorcontrib><creatorcontrib>Nielsen, Sten Lyager</creatorcontrib><creatorcontrib>Hasenkam, J. Michael</creatorcontrib><creatorcontrib>Smerup, Morten</creatorcontrib><title>A catheter based chronic porcine model of post-infarct dilated heart failure</title><title>Scandinavian cardiovascular journal : SCJ</title><addtitle>Scand Cardiovasc J</addtitle><description>Objectives. New surgical treatments for post-infarct antero-septal myocardial akinesia have been developed but evaluation of their mode of function is hampered by absence of suitable large animal heart failure models. We aimed to develop and evaluate a human compatible model for chronic post-infarct left ventricular (LV) remodeling. Design. Fourteen female 50 kg pigs underwent catheter-based coronary artery occlusion (one hour) distal to the first LAD diagonal. Eight weight- and age-matched healthy animals served as controls. LV geometry and function were assessed after 6 weeks with cardiovascular MRI. Results. All animals recovered from interventions. Three animals died during follow-up. All intervention animals had antero-septal akinetic infarcts (mean 26.5% of LV myocardium). Intervention animals had significantly increased end-diastolic and end-systolic volumes, and decreased stroke volume, ejection fraction and cardiac output. Detailed functional analysis showed significant systolic- and diastolic-dysfunction in intervention animals. Conclusions. We have established a feasible model of post-infarct LV remodeling, which accurately simulates human pathogenesis and pathophysiology. The model may be suitable for evaluation of novel surgical alleviations for heart failure.</description><subject>Animals</subject><subject>Cardiac Catheterization - adverse effects</subject><subject>Cardiac Output</subject><subject>Disease Models, Animal</subject><subject>experimental models</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>heart failure</subject><subject>Heart Failure - etiology</subject><subject>Heart Failure - pathology</subject><subject>Heart Failure - physiopathology</subject><subject>heart failure surgery</subject><subject>Hypertrophy, Left Ventricular - etiology</subject><subject>Hypertrophy, Left Ventricular - pathology</subject><subject>Hypertrophy, Left Ventricular - physiopathology</subject><subject>ischemic heart disease</subject><subject>Left ventricle</subject><subject>Magnetic Resonance Imaging</subject><subject>Myocardial Infarction - complications</subject><subject>Myocardial Infarction - etiology</subject><subject>Myocardial Infarction - pathology</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Myocardium - pathology</subject><subject>Reproducibility of Results</subject><subject>Stroke Volume</subject><subject>Swine</subject><subject>Time Factors</subject><subject>Ventricular Dysfunction, Left - etiology</subject><subject>Ventricular Dysfunction, Left - pathology</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><subject>Ventricular Remodeling</subject><issn>1401-7431</issn><issn>1651-2006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVJaT7aH9BL8Ck3J_r2mvQSQr9gIZf2LMbSmHWQrc1IpuTfR2UXQinkNMPoeV_Ew9hnwa8F3_AbobnotKqrtFxzpd-xM2GNaCXn9qTu9b2tgDhl5zk_ci7MxogP7FT03BqtuzO2vWs8lB0WpGaAjKHxO0rL5Jt9Ij8t2MwpYGzSWA-5tNMyAvnShClCqfQOgUozwhRXwo_s_Qgx46fjvGC_v339df-j3T58_3l_t2296vvSml4aaaHzIQipDFe9lQNYH_jGC69kp81mwE6hGQYDwmDoPUg9dFryoHtUF-zq0Lun9LRiLm6esscYYcG0Zmc7I4WypoLiAHpKOROObk_TDPTsBHd_Fbr_FNbM5bF8HWYMr4mjswp8OQDVRaIZ_iSKwRV4jolGgsVP2am3-m__iVeDsew8ELrHtNJSxb3xuxcKD5Ab</recordid><startdate>20090101</startdate><enddate>20090101</enddate><creator>Brødløs, Hans Kristian</creator><creator>Bramsen, Morten B.</creator><creator>Agger, Peter</creator><creator>Jensen, Henrik</creator><creator>Bjerre, Marianne</creator><creator>Ringgaard, Steffen</creator><creator>Wierup, Per</creator><creator>Nielsen, Sten Lyager</creator><creator>Hasenkam, J. Michael</creator><creator>Smerup, Morten</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090101</creationdate><title>A catheter based chronic porcine model of post-infarct dilated heart failure</title><author>Brødløs, Hans Kristian ; Bramsen, Morten B. ; Agger, Peter ; Jensen, Henrik ; Bjerre, Marianne ; Ringgaard, Steffen ; Wierup, Per ; Nielsen, Sten Lyager ; Hasenkam, J. Michael ; Smerup, Morten</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-592526a7cdd123503962ba6cd08c1c327458be73e5bb5a15ed9ca24b7420d49e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Cardiac Catheterization - adverse effects</topic><topic>Cardiac Output</topic><topic>Disease Models, Animal</topic><topic>experimental models</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>heart failure</topic><topic>Heart Failure - etiology</topic><topic>Heart Failure - pathology</topic><topic>Heart Failure - physiopathology</topic><topic>heart failure surgery</topic><topic>Hypertrophy, Left Ventricular - etiology</topic><topic>Hypertrophy, Left Ventricular - pathology</topic><topic>Hypertrophy, Left Ventricular - physiopathology</topic><topic>ischemic heart disease</topic><topic>Left ventricle</topic><topic>Magnetic Resonance Imaging</topic><topic>Myocardial Infarction - complications</topic><topic>Myocardial Infarction - etiology</topic><topic>Myocardial Infarction - pathology</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Myocardium - pathology</topic><topic>Reproducibility of Results</topic><topic>Stroke Volume</topic><topic>Swine</topic><topic>Time Factors</topic><topic>Ventricular Dysfunction, Left - etiology</topic><topic>Ventricular Dysfunction, Left - pathology</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><topic>Ventricular Remodeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brødløs, Hans Kristian</creatorcontrib><creatorcontrib>Bramsen, Morten B.</creatorcontrib><creatorcontrib>Agger, Peter</creatorcontrib><creatorcontrib>Jensen, Henrik</creatorcontrib><creatorcontrib>Bjerre, Marianne</creatorcontrib><creatorcontrib>Ringgaard, Steffen</creatorcontrib><creatorcontrib>Wierup, Per</creatorcontrib><creatorcontrib>Nielsen, Sten Lyager</creatorcontrib><creatorcontrib>Hasenkam, J. Michael</creatorcontrib><creatorcontrib>Smerup, Morten</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian cardiovascular journal : SCJ</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brødløs, Hans Kristian</au><au>Bramsen, Morten B.</au><au>Agger, Peter</au><au>Jensen, Henrik</au><au>Bjerre, Marianne</au><au>Ringgaard, Steffen</au><au>Wierup, Per</au><au>Nielsen, Sten Lyager</au><au>Hasenkam, J. Michael</au><au>Smerup, Morten</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A catheter based chronic porcine model of post-infarct dilated heart failure</atitle><jtitle>Scandinavian cardiovascular journal : SCJ</jtitle><addtitle>Scand Cardiovasc J</addtitle><date>2009-01-01</date><risdate>2009</risdate><volume>43</volume><issue>4</issue><spage>260</spage><epage>266</epage><pages>260-266</pages><issn>1401-7431</issn><eissn>1651-2006</eissn><abstract>Objectives. New surgical treatments for post-infarct antero-septal myocardial akinesia have been developed but evaluation of their mode of function is hampered by absence of suitable large animal heart failure models. We aimed to develop and evaluate a human compatible model for chronic post-infarct left ventricular (LV) remodeling. Design. Fourteen female 50 kg pigs underwent catheter-based coronary artery occlusion (one hour) distal to the first LAD diagonal. Eight weight- and age-matched healthy animals served as controls. LV geometry and function were assessed after 6 weeks with cardiovascular MRI. Results. All animals recovered from interventions. Three animals died during follow-up. All intervention animals had antero-septal akinetic infarcts (mean 26.5% of LV myocardium). Intervention animals had significantly increased end-diastolic and end-systolic volumes, and decreased stroke volume, ejection fraction and cardiac output. Detailed functional analysis showed significant systolic- and diastolic-dysfunction in intervention animals. Conclusions. We have established a feasible model of post-infarct LV remodeling, which accurately simulates human pathogenesis and pathophysiology. The model may be suitable for evaluation of novel surgical alleviations for heart failure.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>19065447</pmid><doi>10.1080/14017430802604034</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Scandinavian cardiovascular journal : SCJ, 2009-01, Vol.43 (4), p.260-266 |
| issn | 1401-7431 1651-2006 |
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| source | MEDLINE; Taylor & Francis Journals Complete |
| subjects | Animals Cardiac Catheterization - adverse effects Cardiac Output Disease Models, Animal experimental models Feasibility Studies Female heart failure Heart Failure - etiology Heart Failure - pathology Heart Failure - physiopathology heart failure surgery Hypertrophy, Left Ventricular - etiology Hypertrophy, Left Ventricular - pathology Hypertrophy, Left Ventricular - physiopathology ischemic heart disease Left ventricle Magnetic Resonance Imaging Myocardial Infarction - complications Myocardial Infarction - etiology Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardium - pathology Reproducibility of Results Stroke Volume Swine Time Factors Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - pathology Ventricular Dysfunction, Left - physiopathology Ventricular Remodeling |
| title | A catheter based chronic porcine model of post-infarct dilated heart failure |
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