Tec family kinases in T lymphocyte development and function

The Tec family tyrosine kinases are now recognized as important mediators of antigen receptor signaling in lymphocytes. Three members of this family, Itk, Rlk, and Tec, are expressed in T cells and activated in response to T cell receptor (TCR) engagement. Although initial studies demonstrated a rol...

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Veröffentlicht in:	Annual review of immunology 2005-01, Vol.23 (1), p.549-600
Hauptverfasser:	Berg, Leslie J, Finkelstein, Lisa D, Lucas, Julie A, Schwartzberg, Pamela L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD28 Antigens - metabolism Enzyme Activation Humans Mice Models, Immunological Molecular Structure Protein Structure, Tertiary Protein-Tyrosine Kinases - chemistry Protein-Tyrosine Kinases - immunology Receptors, Antigen, T-Cell - metabolism Signal Transduction T-Lymphocytes - cytology T-Lymphocytes - enzymology T-Lymphocytes - immunology
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