Relationship between the triglyceride/high-density lipoprotein-cholesterol ratio, insulin resistance index and cardiometabolic risk factors in women with polycystic ovary syndrome
To evaluate the relationship between the triglyceride/high density lipoprotein cholesterol (TG/HDL-c) ratio, insulin resistance index and cardiometabolic risk factors in women with polycystic ovary syndrome (PCOS). The present crosssectional study analyzed 62 women with PCOS and 48 healthy women (co...
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| Veröffentlicht in: | Endocrinologia y nutricion 2009-02, Vol.56 (2), p.59-65 |
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| creator | Roa Barrios, Marlene Arata-Bellabarba, Gabriela Valeri, Lenin Velázquez-Maldonado, Elsy |
| description | To evaluate the relationship between the triglyceride/high density lipoprotein cholesterol (TG/HDL-c) ratio, insulin resistance index and cardiometabolic risk factors in women with polycystic ovary syndrome (PCOS).
The present crosssectional study analyzed 62 women with PCOS and 48 healthy women (control group) aged 17- 35 years old. Body mass index (BMI), waist circumference (WC) and blood pressure were registered. Plasma concentrations of glucose, insulin, triglycerides, total cholesterol and HDL-c were measured. TheTG/HDL-c ratio, homeostasis model assessment for insulin resistance (HOMA(IR)) and quantitative insulin sensitivity check index (QUICKI) were calculated.
Women with PCOS showed significantly higher values of the TG/HDL-c ratio and HOMA(IR), and a significantly lower QUICKI value. These differences were related to BMI and WC, with the highest values being observed in obese patients. The 50th percentile for the TG/HDL-c ratio was 3.64; the TG/cHDL ratio was positively correlated with BMI, WC and HOMA(IR) (r=0.48, p |
| doi_str_mv | 10.1016/s1575-0922(09)70553-4 |
| format | Article |
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The present crosssectional study analyzed 62 women with PCOS and 48 healthy women (control group) aged 17- 35 years old. Body mass index (BMI), waist circumference (WC) and blood pressure were registered. Plasma concentrations of glucose, insulin, triglycerides, total cholesterol and HDL-c were measured. TheTG/HDL-c ratio, homeostasis model assessment for insulin resistance (HOMA(IR)) and quantitative insulin sensitivity check index (QUICKI) were calculated.
Women with PCOS showed significantly higher values of the TG/HDL-c ratio and HOMA(IR), and a significantly lower QUICKI value. These differences were related to BMI and WC, with the highest values being observed in obese patients. The 50th percentile for the TG/HDL-c ratio was 3.64; the TG/cHDL ratio was positively correlated with BMI, WC and HOMA(IR) (r=0.48, p<0.001; r=0.58, p<0.001; r=0.43, p<0.001 respectively) and was negatively correlated with the QUICKI (r=-0.51; p<0.001). Women with PCOS showed a higher frequency of fasting glucose > 100 mg/dl (10% vs 3%; p<0.05), triglycerides>150 mg/dl (55% vs 20%; p<0.05) and WC>80 cm (82.3% vs 43.8%; p<0.001). Metabolic syndrome was also more frequent in women with PCOS than in controls (31% vs 10%). The independent variable with the strongest influence on TG/HDL-c was WC (p<0.001).
This cross-sectional study demonstrates that women with PCOS show significantly higher values of the TG/HDL-c ratio, which is closely related to WC and insulin resistance and sensitivity indexes (HOMA(IR), QUICKI). The TG/HDL-c ratio could be considered as a useful and practical method to identify an increased risk of cardiovascular disease in patients with PCOS.]]></description><identifier>ISSN: 1575-0922</identifier><identifier>DOI: 10.1016/s1575-0922(09)70553-4</identifier><identifier>PMID: 19627713</identifier><language>spa</language><publisher>Spain</publisher><subject>Adolescent ; Adult ; Anthropometry ; Blood Glucose - analysis ; Cardiovascular Diseases - epidemiology ; Cholesterol, HDL - blood ; Comorbidity ; Cross-Sectional Studies ; Disease Susceptibility ; Dyslipidemias - epidemiology ; Ethnic Groups ; Female ; Humans ; Insulin Resistance ; Metabolic Syndrome - epidemiology ; Obesity - blood ; Obesity - epidemiology ; Polycystic Ovary Syndrome - blood ; Polycystic Ovary Syndrome - epidemiology ; Risk Factors ; Triglycerides - blood ; Venezuela - epidemiology ; Young Adult</subject><ispartof>Endocrinologia y nutricion, 2009-02, Vol.56 (2), p.59-65</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1063-68a22616099475ad0b2c6b44b26d8853ccdf547510cba0f9919e2bba3fb06333</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19627713$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roa Barrios, Marlene</creatorcontrib><creatorcontrib>Arata-Bellabarba, Gabriela</creatorcontrib><creatorcontrib>Valeri, Lenin</creatorcontrib><creatorcontrib>Velázquez-Maldonado, Elsy</creatorcontrib><title>Relationship between the triglyceride/high-density lipoprotein-cholesterol ratio, insulin resistance index and cardiometabolic risk factors in women with polycystic ovary syndrome</title><title>Endocrinologia y nutricion</title><addtitle>Endocrinol Nutr</addtitle><description><![CDATA[To evaluate the relationship between the triglyceride/high density lipoprotein cholesterol (TG/HDL-c) ratio, insulin resistance index and cardiometabolic risk factors in women with polycystic ovary syndrome (PCOS).
The present crosssectional study analyzed 62 women with PCOS and 48 healthy women (control group) aged 17- 35 years old. Body mass index (BMI), waist circumference (WC) and blood pressure were registered. Plasma concentrations of glucose, insulin, triglycerides, total cholesterol and HDL-c were measured. TheTG/HDL-c ratio, homeostasis model assessment for insulin resistance (HOMA(IR)) and quantitative insulin sensitivity check index (QUICKI) were calculated.
Women with PCOS showed significantly higher values of the TG/HDL-c ratio and HOMA(IR), and a significantly lower QUICKI value. These differences were related to BMI and WC, with the highest values being observed in obese patients. The 50th percentile for the TG/HDL-c ratio was 3.64; the TG/cHDL ratio was positively correlated with BMI, WC and HOMA(IR) (r=0.48, p<0.001; r=0.58, p<0.001; r=0.43, p<0.001 respectively) and was negatively correlated with the QUICKI (r=-0.51; p<0.001). Women with PCOS showed a higher frequency of fasting glucose > 100 mg/dl (10% vs 3%; p<0.05), triglycerides>150 mg/dl (55% vs 20%; p<0.05) and WC>80 cm (82.3% vs 43.8%; p<0.001). Metabolic syndrome was also more frequent in women with PCOS than in controls (31% vs 10%). The independent variable with the strongest influence on TG/HDL-c was WC (p<0.001).
This cross-sectional study demonstrates that women with PCOS show significantly higher values of the TG/HDL-c ratio, which is closely related to WC and insulin resistance and sensitivity indexes (HOMA(IR), QUICKI). The TG/HDL-c ratio could be considered as a useful and practical method to identify an increased risk of cardiovascular disease in patients with PCOS.]]></description><subject>Adolescent</subject><subject>Adult</subject><subject>Anthropometry</subject><subject>Blood Glucose - analysis</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cholesterol, HDL - blood</subject><subject>Comorbidity</subject><subject>Cross-Sectional Studies</subject><subject>Disease Susceptibility</subject><subject>Dyslipidemias - epidemiology</subject><subject>Ethnic Groups</subject><subject>Female</subject><subject>Humans</subject><subject>Insulin Resistance</subject><subject>Metabolic Syndrome - epidemiology</subject><subject>Obesity - blood</subject><subject>Obesity - epidemiology</subject><subject>Polycystic Ovary Syndrome - blood</subject><subject>Polycystic Ovary Syndrome - epidemiology</subject><subject>Risk Factors</subject><subject>Triglycerides - blood</subject><subject>Venezuela - epidemiology</subject><subject>Young Adult</subject><issn>1575-0922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UMtuFDEQ9AFEwpJPAPmEiJQhfqw96yOKCEGKhIRyX_nRk2nw2oPtJcx35QcxInDplqqqq7uakNecveeM68vK1agGZoR4x8z5yJSSw_YZOf0Pn5CXtX5jTCgjxQtywo0W48jlKXn8CtE2zKnOuFAH7QEg0TYDbQXv4-qhYIDLGe_nIUCq2FYacclLyQ0wDX7OEWqDkiMtf4wuKKZ6jJhogYq12eShQwF-UZsC9bYEzAdo1uWInhas3-lkfculdhl96Fyv2Ga65L5-ra2r8k9bVlrXFErnX5Hnk40Vzp76htxdf7y7uhluv3z6fPXhdvCcaTnonRVCc82M2Y7KBuaE1267dUKH3U5J78OkOsOZd5ZNxnADwjkrJ9fHpdyQt39te9Yfxx5yf8DqIUabIB_rXo9KMNaNNuTNk_DoDhD2S8FDv3f_78vyN50ShCs</recordid><startdate>200902</startdate><enddate>200902</enddate><creator>Roa Barrios, Marlene</creator><creator>Arata-Bellabarba, Gabriela</creator><creator>Valeri, Lenin</creator><creator>Velázquez-Maldonado, Elsy</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200902</creationdate><title>Relationship between the triglyceride/high-density lipoprotein-cholesterol ratio, insulin resistance index and cardiometabolic risk factors in women with polycystic ovary syndrome</title><author>Roa Barrios, Marlene ; Arata-Bellabarba, Gabriela ; Valeri, Lenin ; Velázquez-Maldonado, Elsy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1063-68a22616099475ad0b2c6b44b26d8853ccdf547510cba0f9919e2bba3fb06333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>spa</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anthropometry</topic><topic>Blood Glucose - analysis</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cholesterol, HDL - blood</topic><topic>Comorbidity</topic><topic>Cross-Sectional Studies</topic><topic>Disease Susceptibility</topic><topic>Dyslipidemias - epidemiology</topic><topic>Ethnic Groups</topic><topic>Female</topic><topic>Humans</topic><topic>Insulin Resistance</topic><topic>Metabolic Syndrome - epidemiology</topic><topic>Obesity - blood</topic><topic>Obesity - epidemiology</topic><topic>Polycystic Ovary Syndrome - blood</topic><topic>Polycystic Ovary Syndrome - epidemiology</topic><topic>Risk Factors</topic><topic>Triglycerides - blood</topic><topic>Venezuela - epidemiology</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Roa Barrios, Marlene</creatorcontrib><creatorcontrib>Arata-Bellabarba, Gabriela</creatorcontrib><creatorcontrib>Valeri, Lenin</creatorcontrib><creatorcontrib>Velázquez-Maldonado, Elsy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrinologia y nutricion</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roa Barrios, Marlene</au><au>Arata-Bellabarba, Gabriela</au><au>Valeri, Lenin</au><au>Velázquez-Maldonado, Elsy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between the triglyceride/high-density lipoprotein-cholesterol ratio, insulin resistance index and cardiometabolic risk factors in women with polycystic ovary syndrome</atitle><jtitle>Endocrinologia y nutricion</jtitle><addtitle>Endocrinol Nutr</addtitle><date>2009-02</date><risdate>2009</risdate><volume>56</volume><issue>2</issue><spage>59</spage><epage>65</epage><pages>59-65</pages><issn>1575-0922</issn><abstract><![CDATA[To evaluate the relationship between the triglyceride/high density lipoprotein cholesterol (TG/HDL-c) ratio, insulin resistance index and cardiometabolic risk factors in women with polycystic ovary syndrome (PCOS).
The present crosssectional study analyzed 62 women with PCOS and 48 healthy women (control group) aged 17- 35 years old. Body mass index (BMI), waist circumference (WC) and blood pressure were registered. Plasma concentrations of glucose, insulin, triglycerides, total cholesterol and HDL-c were measured. TheTG/HDL-c ratio, homeostasis model assessment for insulin resistance (HOMA(IR)) and quantitative insulin sensitivity check index (QUICKI) were calculated.
Women with PCOS showed significantly higher values of the TG/HDL-c ratio and HOMA(IR), and a significantly lower QUICKI value. These differences were related to BMI and WC, with the highest values being observed in obese patients. The 50th percentile for the TG/HDL-c ratio was 3.64; the TG/cHDL ratio was positively correlated with BMI, WC and HOMA(IR) (r=0.48, p<0.001; r=0.58, p<0.001; r=0.43, p<0.001 respectively) and was negatively correlated with the QUICKI (r=-0.51; p<0.001). Women with PCOS showed a higher frequency of fasting glucose > 100 mg/dl (10% vs 3%; p<0.05), triglycerides>150 mg/dl (55% vs 20%; p<0.05) and WC>80 cm (82.3% vs 43.8%; p<0.001). Metabolic syndrome was also more frequent in women with PCOS than in controls (31% vs 10%). The independent variable with the strongest influence on TG/HDL-c was WC (p<0.001).
This cross-sectional study demonstrates that women with PCOS show significantly higher values of the TG/HDL-c ratio, which is closely related to WC and insulin resistance and sensitivity indexes (HOMA(IR), QUICKI). The TG/HDL-c ratio could be considered as a useful and practical method to identify an increased risk of cardiovascular disease in patients with PCOS.]]></abstract><cop>Spain</cop><pmid>19627713</pmid><doi>10.1016/s1575-0922(09)70553-4</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Free E-Journal (出版社公開部分のみ）; ScienceDirect Freedom Collection (Elsevier) |
| subjects | Adolescent Adult Anthropometry Blood Glucose - analysis Cardiovascular Diseases - epidemiology Cholesterol, HDL - blood Comorbidity Cross-Sectional Studies Disease Susceptibility Dyslipidemias - epidemiology Ethnic Groups Female Humans Insulin Resistance Metabolic Syndrome - epidemiology Obesity - blood Obesity - epidemiology Polycystic Ovary Syndrome - blood Polycystic Ovary Syndrome - epidemiology Risk Factors Triglycerides - blood Venezuela - epidemiology Young Adult |
| title | Relationship between the triglyceride/high-density lipoprotein-cholesterol ratio, insulin resistance index and cardiometabolic risk factors in women with polycystic ovary syndrome |
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