Attenuated Plaque at Nonculprit Lesions in Patients Enrolled in Intravascular Ultrasound Atherosclerosis Progression Trials
Attenuated Plaque at Nonculprit Lesions in Patients Enrolled in Intravascular Ultrasound Atherosclerosis Progression Trials Ozgur Bayturan, E. Murat Tuzcu, Stephen J. Nicholls, Craig Balog, Andrea Lavoie, Kiyoko Uno, Timothy D. Crowe, William A. Magyar, Kathy Wolski, Samir Kapadia, Steven E. Nissen,...
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| Veröffentlicht in: | JACC. Cardiovascular interventions 2009-07, Vol.2 (7), p.672-678 |
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| creator | Bayturan, Ozgur, MD Tuzcu, E. Murat, MD Nicholls, Stephen J., MBBS, PhD Balog, Craig, BS Lavoie, Andrea, MD Uno, Kiyoko, MD Crowe, Timothy D., BS Magyar, William A., BS Wolski, Kathy, MPH Kapadia, Samir, MD Nissen, Steven E., MD Schoenhagen, Paul, MD |
| description | Attenuated Plaque at Nonculprit Lesions in Patients Enrolled in Intravascular Ultrasound Atherosclerosis Progression Trials Ozgur Bayturan, E. Murat Tuzcu, Stephen J. Nicholls, Craig Balog, Andrea Lavoie, Kiyoko Uno, Timothy D. Crowe, William A. Magyar, Kathy Wolski, Samir Kapadia, Steven E. Nissen, Paul Schoenhagen This study was designed to evaluate the presence of attenuated plaque serially (baseline and 2-year follow-up) in 159 nonculprit coronary segments. Attenuated plaque was found in 17 of 159 patients (10.7%, 95% confidence interval: 6% to 17%). At baseline, there were no significant differences in clinical presentation and cardiovascular risk factors between patients with and without attenuation. During follow-up, attenuation remained stable, and no events occurred in the patients with attenuation. There was a relationship with mixed calcified lesions. These findings challenge the previous assumption that attenuated plaque is a finding limited to culprit lesions associated with acute clinical presentation. |
| doi_str_mv | 10.1016/j.jcin.2009.05.007 |
| format | Article |
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Murat, MD ; Nicholls, Stephen J., MBBS, PhD ; Balog, Craig, BS ; Lavoie, Andrea, MD ; Uno, Kiyoko, MD ; Crowe, Timothy D., BS ; Magyar, William A., BS ; Wolski, Kathy, MPH ; Kapadia, Samir, MD ; Nissen, Steven E., MD ; Schoenhagen, Paul, MD</creator><creatorcontrib>Bayturan, Ozgur, MD ; Tuzcu, E. Murat, MD ; Nicholls, Stephen J., MBBS, PhD ; Balog, Craig, BS ; Lavoie, Andrea, MD ; Uno, Kiyoko, MD ; Crowe, Timothy D., BS ; Magyar, William A., BS ; Wolski, Kathy, MPH ; Kapadia, Samir, MD ; Nissen, Steven E., MD ; Schoenhagen, Paul, MD</creatorcontrib><description>Attenuated Plaque at Nonculprit Lesions in Patients Enrolled in Intravascular Ultrasound Atherosclerosis Progression Trials Ozgur Bayturan, E. Murat Tuzcu, Stephen J. Nicholls, Craig Balog, Andrea Lavoie, Kiyoko Uno, Timothy D. Crowe, William A. Magyar, Kathy Wolski, Samir Kapadia, Steven E. Nissen, Paul Schoenhagen This study was designed to evaluate the presence of attenuated plaque serially (baseline and 2-year follow-up) in 159 nonculprit coronary segments. Attenuated plaque was found in 17 of 159 patients (10.7%, 95% confidence interval: 6% to 17%). At baseline, there were no significant differences in clinical presentation and cardiovascular risk factors between patients with and without attenuation. During follow-up, attenuation remained stable, and no events occurred in the patients with attenuation. There was a relationship with mixed calcified lesions. These findings challenge the previous assumption that attenuated plaque is a finding limited to culprit lesions associated with acute clinical presentation.</description><identifier>ISSN: 1936-8798</identifier><identifier>EISSN: 1876-7605</identifier><identifier>DOI: 10.1016/j.jcin.2009.05.007</identifier><identifier>PMID: 19628192</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Atherosclerosis - complications ; Atherosclerosis - diagnostic imaging ; Atherosclerosis - drug therapy ; Calcinosis - diagnostic imaging ; Cardiovascular ; coronary artery disease ; Disease Progression ; Female ; Fluorobenzenes - therapeutic use ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; imaging ; intravascular ultrasound ; Male ; Middle Aged ; Predictive Value of Tests ; Pyrimidines - therapeutic use ; Rosuvastatin Calcium ; Sulfonamides - therapeutic use ; Time Factors ; Treatment Outcome ; Ultrasonography, Interventional ; vulnerable plaque</subject><ispartof>JACC. 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Murat, MD</creatorcontrib><creatorcontrib>Nicholls, Stephen J., MBBS, PhD</creatorcontrib><creatorcontrib>Balog, Craig, BS</creatorcontrib><creatorcontrib>Lavoie, Andrea, MD</creatorcontrib><creatorcontrib>Uno, Kiyoko, MD</creatorcontrib><creatorcontrib>Crowe, Timothy D., BS</creatorcontrib><creatorcontrib>Magyar, William A., BS</creatorcontrib><creatorcontrib>Wolski, Kathy, MPH</creatorcontrib><creatorcontrib>Kapadia, Samir, MD</creatorcontrib><creatorcontrib>Nissen, Steven E., MD</creatorcontrib><creatorcontrib>Schoenhagen, Paul, MD</creatorcontrib><title>Attenuated Plaque at Nonculprit Lesions in Patients Enrolled in Intravascular Ultrasound Atherosclerosis Progression Trials</title><title>JACC. Cardiovascular interventions</title><addtitle>JACC Cardiovasc Interv</addtitle><description>Attenuated Plaque at Nonculprit Lesions in Patients Enrolled in Intravascular Ultrasound Atherosclerosis Progression Trials Ozgur Bayturan, E. Murat Tuzcu, Stephen J. Nicholls, Craig Balog, Andrea Lavoie, Kiyoko Uno, Timothy D. Crowe, William A. Magyar, Kathy Wolski, Samir Kapadia, Steven E. Nissen, Paul Schoenhagen This study was designed to evaluate the presence of attenuated plaque serially (baseline and 2-year follow-up) in 159 nonculprit coronary segments. Attenuated plaque was found in 17 of 159 patients (10.7%, 95% confidence interval: 6% to 17%). At baseline, there were no significant differences in clinical presentation and cardiovascular risk factors between patients with and without attenuation. During follow-up, attenuation remained stable, and no events occurred in the patients with attenuation. There was a relationship with mixed calcified lesions. 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Murat, MD</creator><creator>Nicholls, Stephen J., MBBS, PhD</creator><creator>Balog, Craig, BS</creator><creator>Lavoie, Andrea, MD</creator><creator>Uno, Kiyoko, MD</creator><creator>Crowe, Timothy D., BS</creator><creator>Magyar, William A., BS</creator><creator>Wolski, Kathy, MPH</creator><creator>Kapadia, Samir, MD</creator><creator>Nissen, Steven E., MD</creator><creator>Schoenhagen, Paul, MD</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090701</creationdate><title>Attenuated Plaque at Nonculprit Lesions in Patients Enrolled in Intravascular Ultrasound Atherosclerosis Progression Trials</title><author>Bayturan, Ozgur, MD ; Tuzcu, E. 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Cardiovascular interventions</jtitle><addtitle>JACC Cardiovasc Interv</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>2</volume><issue>7</issue><spage>672</spage><epage>678</epage><pages>672-678</pages><issn>1936-8798</issn><eissn>1876-7605</eissn><abstract>Attenuated Plaque at Nonculprit Lesions in Patients Enrolled in Intravascular Ultrasound Atherosclerosis Progression Trials Ozgur Bayturan, E. Murat Tuzcu, Stephen J. Nicholls, Craig Balog, Andrea Lavoie, Kiyoko Uno, Timothy D. Crowe, William A. Magyar, Kathy Wolski, Samir Kapadia, Steven E. Nissen, Paul Schoenhagen This study was designed to evaluate the presence of attenuated plaque serially (baseline and 2-year follow-up) in 159 nonculprit coronary segments. Attenuated plaque was found in 17 of 159 patients (10.7%, 95% confidence interval: 6% to 17%). At baseline, there were no significant differences in clinical presentation and cardiovascular risk factors between patients with and without attenuation. During follow-up, attenuation remained stable, and no events occurred in the patients with attenuation. There was a relationship with mixed calcified lesions. These findings challenge the previous assumption that attenuated plaque is a finding limited to culprit lesions associated with acute clinical presentation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>19628192</pmid><doi>10.1016/j.jcin.2009.05.007</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | JACC. Cardiovascular interventions, 2009-07, Vol.2 (7), p.672-678 |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aged Atherosclerosis - complications Atherosclerosis - diagnostic imaging Atherosclerosis - drug therapy Calcinosis - diagnostic imaging Cardiovascular coronary artery disease Disease Progression Female Fluorobenzenes - therapeutic use Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use imaging intravascular ultrasound Male Middle Aged Predictive Value of Tests Pyrimidines - therapeutic use Rosuvastatin Calcium Sulfonamides - therapeutic use Time Factors Treatment Outcome Ultrasonography, Interventional vulnerable plaque |
| title | Attenuated Plaque at Nonculprit Lesions in Patients Enrolled in Intravascular Ultrasound Atherosclerosis Progression Trials |
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