Functional characterization of muscarinic autoreceptors in rat and human neocortex

Electrically evoked overflow of [³H]acetylcholine in slices of rat neocortex and of human neocortex (freshly obtained during neurosurgical treatment of epilepsy or deep-seated tumors) was used to functionally characterize the muscarinic receptor subtype, which mediates autoinhibition of acetylcholin...

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Veröffentlicht in:	Journal of neurochemistry 2009-08, Vol.110 (3), p.837-847
Hauptverfasser:	Stoll, Christoph, Eltze, Manfrid, Lambrecht, Günter, Zentner, Josef, Feuerstein, Thomas J, Jackisch, Rolf
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholine release Adolescent Adult Alzheimer disease Alzheimer’s disease Animals Autoreceptors - antagonists & inhibitors Autoreceptors - classification Autoreceptors - physiology Biochemistry Biological and medical sciences Brain brain slices Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy human neocortex Humans Male Medical sciences Middle Aged Muscarinic Antagonists - pharmacology muscarinic autoreceptor Neocortex - drug effects Neocortex - physiology Nervous system (semeiology, syndromes) Neurology Neurotransmitters rat neocortex Rats Rats, Wistar Receptors, Muscarinic - classification Receptors, Muscarinic - physiology Rodents Species Specificity
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