Macrophage-derived interleukin-18 in experimental renal allograft rejection

Background. Interleukin 18 (IL-18) is primarily a macrophage-derived, pro-inflammatory cytokine. As macrophages can act as effector cells in acute rejection, we examined the role of IL-18 in a rat model of acute renal allograft rejection. Methods. Life-sustaining orthotopic DA to Lewis allograft and...

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Veröffentlicht in:	Nephrology, dialysis, transplantation dialysis, transplantation, 2005-04, Vol.20 (4), p.699-706
Hauptverfasser:	Wyburn, Kate, Wu, Huiling, Yin, Jianlin, Jose, Matthew, Eris, Josette, Chadban, Steven
Format:	Artikel
Sprache:	eng
Schlagworte:	acute allograft rejection Acute Disease Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Emergency and intensive care: renal failure. Dialysis management Graft Rejection - immunology Intensive care medicine interleukin-18 Interleukin-8 - immunology kidney transplantation Kidney Transplantation - immunology macrophages Macrophages - immunology Male Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Rats Rats, Inbred Lew Renal failure Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system
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