Isolation and Characterization of a Novel Proopiomelanocortin-Derived Peptide from Hemofiltrate of Chronic Renal Failure Patients

We report the isolation of a novel human circulating proopiomelanocortin-derived peptide, VA-β-MSH, from hemofiltrate and its pharmacological characterization. Screening for lipolytic activity in differentiated 3T3-L1 adipocytes led to the isolation from a hemofiltrate peptide library by alternating...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2005-04, Vol.146 (4), p.2060-2068
Hauptverfasser:	Fricke, Katrin, Schulz, Axel, John, Harald, Forssmann, Wolf-Georg, Maronde, Erik
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Adenosine Adenosine kinase Adenylyl Cyclases - metabolism Adipocytes Amino Acid Sequence Animals beta-MSH - chemistry beta-MSH - isolation & purification beta-MSH - pharmacology Biological and medical sciences Cation exchange Cation exchanging Cell differentiation Circulation Cyclic AMP Cyclic AMP-Dependent Protein Kinases - physiology Enzyme-linked immunosorbent assay Functionals Fundamental and applied biological sciences. Psychology Hemofiltration Humans Kidney Failure, Chronic - metabolism Kinases Lipolysis Medical sciences Melanocortin Mice Molecular Sequence Data Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Peptides Proopiomelanocortin Protein kinase A Proteomics Receptor, Melanocortin, Type 2 - analysis Receptors, Corticotropin - analysis Receptors, Melanocortin Renal failure Solid phases Vertebrates: endocrinology
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