Increased susceptibility to heart failure in response to volume overload in mice lacking natriuretic peptide receptor-A gene

Contribution of the natriuretic peptide system to the development of heart failure (HF) in vivo was examined using mice lacking or having decreased natriuretic peptide receptor-A (NPRA), a guanylyl cyclase-linked receptor. Volume-overloaded HF was produced by aortocaval fistula in mice with wild-typ...

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Veröffentlicht in:	Cardiovascular research 2005-04, Vol.66 (1), p.94-103
Hauptverfasser:	NISHIKIMI, Toshio, HAGAMAN, John R, TAKAHASHI, Nobuyuki, KIM, Hyung-Suk, MATSUOKA, Hiroaki, SMITHIES, Oliver, MAEDA, Nobuyo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldosterone - blood Angiotensin I - blood Animals Atrial Natriuretic Factor - blood Atrial Natriuretic Factor - genetics Biological and medical sciences Blood Volume Cardiology. Vascular system Cyclic GMP - blood Cyclic GMP - urine Disease Susceptibility Guanylate Cyclase - genetics Guanylate Cyclase - metabolism Heart Heart Failure - genetics Heart Failure - metabolism Heart failure, cardiogenic pulmonary edema, cardiac enlargement Medical sciences Mice Mice, Inbred C57BL Mice, Mutant Strains Models, Animal Myocardium - metabolism Myosin Heavy Chains - genetics Natriuretic Peptide, Brain - genetics Protein Isoforms - genetics Receptors, Atrial Natriuretic Factor - genetics Receptors, Atrial Natriuretic Factor - metabolism Renin - blood Renin-Angiotensin System - physiology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Signal Transduction - physiology
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