DNA damage response and cellular senescence in tissues of aging mice

Summary The impact of cellular senescence onto aging of organisms is not fully clear, not at least because of the scarcity of reliable data on the mere frequency of senescent cells in aging tissues. Activation of a DNA damage response including formation of DNA damage foci containing activated H2A.X...

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Veröffentlicht in:	Aging cell 2009-06, Vol.8 (3), p.311-323
Hauptverfasser:	Wang, Chunfang, Jurk, Diana, Maddick, Mandy, Nelson, Glyn, Martin‐Ruiz, Carmen, Von Zglinicki, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	aging Aging - physiology Animals Cells, Cultured Cellular Senescence - physiology DNA Damage Fibroblasts - chemistry Histones - analysis Intestines - cytology Liver - cytology Male Mice Mice, Inbred C57BL senescence telomere Telomere - chemistry
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