Control of Cell Proliferation and Apoptosis by Mob as Tumor Suppressor, Mats
Appropriate cell number and organ size in a multicellular organism are determined by coordinated cell growth, proliferation, and apoptosis. Disruption of these processes can cause cancer. Recent studies have identified the Large tumor suppressor (Lats)/Warts (Wts) protein kinase as a key component o...
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| Veröffentlicht in: | Cell 2005-03, Vol.120 (5), p.675-685 |
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| creator | Lai, Zhi-Chun Wei, Xiaomu Shimizu, Takeshi Ramos, Edward Rohrbaugh, Margaret Nikolaidis, Nikolas Ho, Li-Lun Li, Ying |
| description | Appropriate cell number and organ size in a multicellular organism are determined by coordinated cell growth, proliferation, and apoptosis. Disruption of these processes can cause cancer. Recent studies have identified the Large tumor suppressor (Lats)/Warts (Wts) protein kinase as a key component of a pathway that controls the coordination between cell proliferation and apoptosis. Here we describe growth inhibitory functions for a Mob superfamily protein, termed Mats (Mob as tumor suppressor), in
Drosophila. Loss of Mats function results in increased cell proliferation, defective apoptosis, and induction of tissue overgrowth. We show that
mats and
wts function in a common pathway. Mats physically associates with Wts to stimulate the catalytic activity of the Wts kinase. A human Mats ortholog (Mats1) can rescue the lethality associated with loss of Mats function in
Drosophila. As
Mats1 is mutated in human tumors, Mats-mediated growth inhibition and tumor suppression is likely conserved in humans. |
| doi_str_mv | 10.1016/j.cell.2004.12.036 |
| format | Article |
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Drosophila. Loss of Mats function results in increased cell proliferation, defective apoptosis, and induction of tissue overgrowth. We show that
mats and
wts function in a common pathway. Mats physically associates with Wts to stimulate the catalytic activity of the Wts kinase. A human Mats ortholog (Mats1) can rescue the lethality associated with loss of Mats function in
Drosophila. As
Mats1 is mutated in human tumors, Mats-mediated growth inhibition and tumor suppression is likely conserved in humans.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/j.cell.2004.12.036</identifier><identifier>PMID: 15766530</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adaptor Proteins, Signal Transducing ; Animals ; Apoptosis - physiology ; Cell Line ; Cell Proliferation ; Cell Transformation, Neoplastic - genetics ; Cell Transformation, Neoplastic - metabolism ; Conserved Sequence ; DNA, Complementary - analysis ; DNA, Complementary - genetics ; Drosophila ; Drosophila Proteins - genetics ; Drosophila Proteins - isolation & purification ; Drosophila Proteins - metabolism ; Evolution, Molecular ; Gene Expression Regulation, Developmental - genetics ; Humans ; Membrane Proteins - genetics ; Membrane Proteins - metabolism ; Mice ; Microscopy, Electron, Scanning ; Molecular Sequence Data ; Mutation - genetics ; Neoplasms - genetics ; Neoplasms - metabolism ; Nerve Tissue Proteins - genetics ; Nerve Tissue Proteins - metabolism ; Protein Kinases - metabolism ; Sequence Homology, Amino Acid ; Sequence Homology, Nucleic Acid ; Transferases (Other Substituted Phosphate Groups) ; Tumor Suppressor Proteins - genetics ; Tumor Suppressor Proteins - isolation & purification ; Tumor Suppressor Proteins - metabolism</subject><ispartof>Cell, 2005-03, Vol.120 (5), p.675-685</ispartof><rights>2005 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-6f1f1194be8de876a9e6c510acfd1bb4702e963e267194f083736ec36024d6e93</citedby><cites>FETCH-LOGICAL-c495t-6f1f1194be8de876a9e6c510acfd1bb4702e963e267194f083736ec36024d6e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0092867405000036$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15766530$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lai, Zhi-Chun</creatorcontrib><creatorcontrib>Wei, Xiaomu</creatorcontrib><creatorcontrib>Shimizu, Takeshi</creatorcontrib><creatorcontrib>Ramos, Edward</creatorcontrib><creatorcontrib>Rohrbaugh, Margaret</creatorcontrib><creatorcontrib>Nikolaidis, Nikolas</creatorcontrib><creatorcontrib>Ho, Li-Lun</creatorcontrib><creatorcontrib>Li, Ying</creatorcontrib><title>Control of Cell Proliferation and Apoptosis by Mob as Tumor Suppressor, Mats</title><title>Cell</title><addtitle>Cell</addtitle><description>Appropriate cell number and organ size in a multicellular organism are determined by coordinated cell growth, proliferation, and apoptosis. Disruption of these processes can cause cancer. Recent studies have identified the Large tumor suppressor (Lats)/Warts (Wts) protein kinase as a key component of a pathway that controls the coordination between cell proliferation and apoptosis. Here we describe growth inhibitory functions for a Mob superfamily protein, termed Mats (Mob as tumor suppressor), in
Drosophila. Loss of Mats function results in increased cell proliferation, defective apoptosis, and induction of tissue overgrowth. We show that
mats and
wts function in a common pathway. Mats physically associates with Wts to stimulate the catalytic activity of the Wts kinase. A human Mats ortholog (Mats1) can rescue the lethality associated with loss of Mats function in
Drosophila. As
Mats1 is mutated in human tumors, Mats-mediated growth inhibition and tumor suppression is likely conserved in humans.</description><subject>Adaptor Proteins, Signal Transducing</subject><subject>Animals</subject><subject>Apoptosis - physiology</subject><subject>Cell Line</subject><subject>Cell Proliferation</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Cell Transformation, Neoplastic - metabolism</subject><subject>Conserved Sequence</subject><subject>DNA, Complementary - analysis</subject><subject>DNA, Complementary - genetics</subject><subject>Drosophila</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - isolation & purification</subject><subject>Drosophila Proteins - metabolism</subject><subject>Evolution, Molecular</subject><subject>Gene Expression Regulation, Developmental - genetics</subject><subject>Humans</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - metabolism</subject><subject>Mice</subject><subject>Microscopy, Electron, Scanning</subject><subject>Molecular Sequence Data</subject><subject>Mutation - genetics</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - metabolism</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Protein Kinases - metabolism</subject><subject>Sequence Homology, Amino Acid</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>Transferases (Other Substituted Phosphate Groups)</subject><subject>Tumor Suppressor Proteins - genetics</subject><subject>Tumor Suppressor Proteins - isolation & purification</subject><subject>Tumor Suppressor Proteins - metabolism</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9L7DAUR4M80XH0C7iQrFzZem_aJi24keH5B0YU1HVI01vIMNPUpH0w394OM-DOt7pcOL-zOIxdIqQIKG9XqaX1OhUAeYoihUwesRlCpZIclfjDZgCVSEqp8lN2FuMKAMqiKE7YKRZKyiKDGVsufDcEv-a-5YvJxt-mx7UUzOB8x03X8Pve94OPLvJ6y198zU3kH-PGB_4-9n2gGH244S9miOfsuDXrSBeHO2efD38_Fk_J8vXxeXG_TGxeFUMiW2wRq7ymsqFSSVORtAWCsW2DdZ0rEFTJjIRUE9VCmalMks0kiLyRVGVzdr339sF_jRQHvXFx18J05MeopSpQ5kL8F0QlsVSTfs7EHrTBxxio1X1wGxO2GkHvYuuV3u30LrZGoafY0-jqYB_rDTU_k0PdCbjbAzTF-Oco6GgddZYaF8gOuvHuN_83SKyPCw</recordid><startdate>20050311</startdate><enddate>20050311</enddate><creator>Lai, Zhi-Chun</creator><creator>Wei, Xiaomu</creator><creator>Shimizu, Takeshi</creator><creator>Ramos, Edward</creator><creator>Rohrbaugh, Margaret</creator><creator>Nikolaidis, Nikolas</creator><creator>Ho, Li-Lun</creator><creator>Li, Ying</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20050311</creationdate><title>Control of Cell Proliferation and Apoptosis by Mob as Tumor Suppressor, Mats</title><author>Lai, Zhi-Chun ; Wei, Xiaomu ; Shimizu, Takeshi ; Ramos, Edward ; Rohrbaugh, Margaret ; Nikolaidis, Nikolas ; Ho, Li-Lun ; Li, Ying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-6f1f1194be8de876a9e6c510acfd1bb4702e963e267194f083736ec36024d6e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adaptor Proteins, Signal Transducing</topic><topic>Animals</topic><topic>Apoptosis - physiology</topic><topic>Cell Line</topic><topic>Cell Proliferation</topic><topic>Cell Transformation, Neoplastic - genetics</topic><topic>Cell Transformation, Neoplastic - metabolism</topic><topic>Conserved Sequence</topic><topic>DNA, Complementary - analysis</topic><topic>DNA, Complementary - genetics</topic><topic>Drosophila</topic><topic>Drosophila Proteins - genetics</topic><topic>Drosophila Proteins - isolation & purification</topic><topic>Drosophila Proteins - metabolism</topic><topic>Evolution, Molecular</topic><topic>Gene Expression Regulation, Developmental - genetics</topic><topic>Humans</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - metabolism</topic><topic>Mice</topic><topic>Microscopy, Electron, Scanning</topic><topic>Molecular Sequence Data</topic><topic>Mutation - genetics</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - metabolism</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Protein Kinases - metabolism</topic><topic>Sequence Homology, Amino Acid</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>Transferases (Other Substituted Phosphate Groups)</topic><topic>Tumor Suppressor Proteins - genetics</topic><topic>Tumor Suppressor Proteins - isolation & purification</topic><topic>Tumor Suppressor Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lai, Zhi-Chun</creatorcontrib><creatorcontrib>Wei, Xiaomu</creatorcontrib><creatorcontrib>Shimizu, Takeshi</creatorcontrib><creatorcontrib>Ramos, Edward</creatorcontrib><creatorcontrib>Rohrbaugh, Margaret</creatorcontrib><creatorcontrib>Nikolaidis, Nikolas</creatorcontrib><creatorcontrib>Ho, Li-Lun</creatorcontrib><creatorcontrib>Li, Ying</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lai, Zhi-Chun</au><au>Wei, Xiaomu</au><au>Shimizu, Takeshi</au><au>Ramos, Edward</au><au>Rohrbaugh, Margaret</au><au>Nikolaidis, Nikolas</au><au>Ho, Li-Lun</au><au>Li, Ying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Control of Cell Proliferation and Apoptosis by Mob as Tumor Suppressor, Mats</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>2005-03-11</date><risdate>2005</risdate><volume>120</volume><issue>5</issue><spage>675</spage><epage>685</epage><pages>675-685</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>Appropriate cell number and organ size in a multicellular organism are determined by coordinated cell growth, proliferation, and apoptosis. Disruption of these processes can cause cancer. Recent studies have identified the Large tumor suppressor (Lats)/Warts (Wts) protein kinase as a key component of a pathway that controls the coordination between cell proliferation and apoptosis. Here we describe growth inhibitory functions for a Mob superfamily protein, termed Mats (Mob as tumor suppressor), in
Drosophila. Loss of Mats function results in increased cell proliferation, defective apoptosis, and induction of tissue overgrowth. We show that
mats and
wts function in a common pathway. Mats physically associates with Wts to stimulate the catalytic activity of the Wts kinase. A human Mats ortholog (Mats1) can rescue the lethality associated with loss of Mats function in
Drosophila. As
Mats1 is mutated in human tumors, Mats-mediated growth inhibition and tumor suppression is likely conserved in humans.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15766530</pmid><doi>10.1016/j.cell.2004.12.036</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adaptor Proteins, Signal Transducing Animals Apoptosis - physiology Cell Line Cell Proliferation Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Conserved Sequence DNA, Complementary - analysis DNA, Complementary - genetics Drosophila Drosophila Proteins - genetics Drosophila Proteins - isolation & purification Drosophila Proteins - metabolism Evolution, Molecular Gene Expression Regulation, Developmental - genetics Humans Membrane Proteins - genetics Membrane Proteins - metabolism Mice Microscopy, Electron, Scanning Molecular Sequence Data Mutation - genetics Neoplasms - genetics Neoplasms - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Protein Kinases - metabolism Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Transferases (Other Substituted Phosphate Groups) Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - isolation & purification Tumor Suppressor Proteins - metabolism |
| title | Control of Cell Proliferation and Apoptosis by Mob as Tumor Suppressor, Mats |
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