Pentafluorophenyl-Phenyl Interactions in Biphenyl-DNA

We prepared and investigated oligonucleotide duplexes of the sequence d(GATGAC(X)nGCTAG)⋅d(CTAGC(Y)nGTCATC), in which X and Y designate biphenyl‐ (bph) and pentafluorobiphenyl‐ (5Fbph) C‐nucleotides, respectively, and n varies from 0–4. These hydrophobic base substitutes are expected to adopt a zipp...

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Veröffentlicht in:	Chemistry : a European journal 2005-03, Vol.11 (7), p.2125-2129
Hauptverfasser:	Zahn, Alain, Brotschi, Christine, Leumann, Christian J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biphenyl Compounds - chemistry biphenyl derivatives Calorimetry Circular Dichroism DNA - chemistry fluoroarenes isothermal titration calorimetry Molecular Conformation oligonucleotides Oligonucleotides - chemical synthesis Oligonucleotides - chemistry Organophosphorus Compounds - chemical synthesis Organophosphorus Compounds - chemistry Sensitivity and Specificity stacking interactions Temperature Titrimetry
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