COX-2 inhibitor, NS398, enhances Fas-mediated apoptosis via modulation of the PTEN-Akt pathway in human gastric carcinoma cell lines

A variety of human cancer cells are resistant to Fas ligand and anti-Fas antibody induced apoptosis. Previously, we reported that human gastric carcinoma cell lines were resistant to the anti-Fas antibody, CH-11, without interferon-gamma pretreatment in vitro. Cyclooxygenase (COX)-2 is known to be e...

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Veröffentlicht in:	DNA and cell biology 2005-03, Vol.24 (3), p.141-147
Hauptverfasser:	Honjo, Soichiro, Osaki, Mitsuhiko, Ardyanto, Tonang Dwi, Hiramatsu, Toshiki, Maeta, Noritaka, Ito, Hisao
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies - pharmacology Antineoplastic Agents - pharmacology Apoptosis - drug effects Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - pharmacology Down-Regulation Fas Ligand Protein Flow Cytometry Humans In Situ Nick-End Labeling Membrane Glycoproteins - pharmacology Membrane Proteins Nitrobenzenes - pharmacology Phosphoric Monoester Hydrolases - metabolism Phosphorylation Prostaglandin-Endoperoxide Synthases - metabolism Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt PTEN Phosphohydrolase Signal Transduction - drug effects Stomach Neoplasms - metabolism Sulfonamides - pharmacology Tumor Cells, Cultured Tumor Suppressor Proteins - metabolism
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