Blockade of inducible costimulator pathway to prevent acute rejection in rat liver transplantation

Abstract Background The role of inducible costimulator (ICOS) in transplantation immunity remains unclear. Methods A Lewis-to-Brown–Norway (BN) rat liver transplant model was used to explore the effect of ICOS blockade by small interference RNA. Recipient survival rate, number of CD25/ICOS–positive...

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Veröffentlicht in:	The American journal of surgery 2009-08, Vol.198 (2), p.244-249
Hauptverfasser:	Chen, Yong, Ph.D, Liu, Haizhong, M.D, Liu, Zuojin, Ph.D, Liang, Shaoyong, Ph.D, Chen, Jie, M.D, Long, Feiwu, M.D, Peng, Yong, Ph.D, Yan, Lünan, Ph.D, Gong, Jianping, Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute rejection Allografts Animals Antigens, Differentiation, T-Lymphocyte - genetics Antigens, Differentiation, T-Lymphocyte - immunology Apoptosis Biological and medical sciences Blotting, Western CD25 antigen Down-Regulation Gene expression General aspects Graft rejection Graft Rejection - prevention & control Grafts Immunity Immunohistochemistry Immunological tolerance In Situ Nick-End Labeling Indicators and Reagents Inducible costimulator Inducible T-Cell Co-Stimulator Protein Infiltration Interference Interferon Interferon-gamma - blood Lipids Live transplantation Liver Liver - metabolism Liver - pathology Liver transplantation Liver Transplantation - immunology Liver transplants Liver, biliary tract, pancreas, portal circulation, spleen Lymphocytes Lymphocytes T Medical sciences Metastases Microscopy mRNA Plasma levels Prevention and actions Public health. Hygiene Public health. Hygiene-occupational medicine Rats Rejection Reverse Transcriptase Polymerase Chain Reaction Ribonucleic acid RNA RNA interference RNA, Messenger - metabolism RNA-mediated interference Rodents siRNA Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Survival T cell receptors T lymphocyte T-Lymphocytes - metabolism T-Lymphocytes - pathology Transfection Transplantation Tumor Necrosis Factor-alpha - blood Tumor necrosis factor-α γ-Interferon
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