Formation of Core/Shell Nanoparticles with a Lipid Core and Their Application as a Drug Delivery System

A novel preparation method for core/shell nanoparticles with a drug-loaded lipid core was designed and characterized. The lipid core is composed of lecithin and a drug, and the polymeric shell is composed of Pluronics (poly(ethylene oxide)−poly (propylene oxide)−poly(ethylene oxide) triblock copolym...

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Veröffentlicht in:Biomacromolecules 2005-03, Vol.6 (2), p.1062-1067
Hauptverfasser: Oh, Keun Sang, Lee, Kyung Eun, Han, Sung Sik, Cho, Sun Hang, Kim, Dongmin, Yuk, Soon Hong
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container_end_page 1067
container_issue 2
container_start_page 1062
container_title Biomacromolecules
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creator Oh, Keun Sang
Lee, Kyung Eun
Han, Sung Sik
Cho, Sun Hang
Kim, Dongmin
Yuk, Soon Hong
description A novel preparation method for core/shell nanoparticles with a drug-loaded lipid core was designed and characterized. The lipid core is composed of lecithin and a drug, and the polymeric shell is composed of Pluronics (poly(ethylene oxide)−poly (propylene oxide)−poly(ethylene oxide) triblock copolymer, F-127). For the formation of stabilized core/shell nanoparticles, freeze-drying was performed in the presence of trehalose used as a cryoprotectant. Cryogenic transmittance electron microscopy (cryo-TEM), differential scanning calorimetry (DSC), and a particle size analyzer were used to observe the formation of the stabilized core/shell nanoparticles. For the application of the core/shell nanoparticles as a drug carrier, paclitaxel, a potent anticancer drug, was loaded into the core/shell nanoparticles, and the drug loading amount and the drug release pattern were observed.
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The lipid core is composed of lecithin and a drug, and the polymeric shell is composed of Pluronics (poly(ethylene oxide)−poly (propylene oxide)−poly(ethylene oxide) triblock copolymer, F-127). For the formation of stabilized core/shell nanoparticles, freeze-drying was performed in the presence of trehalose used as a cryoprotectant. Cryogenic transmittance electron microscopy (cryo-TEM), differential scanning calorimetry (DSC), and a particle size analyzer were used to observe the formation of the stabilized core/shell nanoparticles. 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source MEDLINE; ACS Publications
subjects Applied sciences
Biological and medical sciences
Calorimetry, Differential Scanning
Cryoelectron Microscopy
Drug Carriers
Drug Compounding
Exact sciences and technology
Forms of application and semi-finished materials
Freeze Drying
General pharmacology
Lipids
Medical sciences
Miscellaneous
Nanostructures
Paclitaxel - administration & dosage
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Phosphatidylcholines
Poloxamer
Polymer industry, paints, wood
Technology of polymers
title Formation of Core/Shell Nanoparticles with a Lipid Core and Their Application as a Drug Delivery System
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