ADAM33 Enzyme Properties and Substrate Specificity

ADAM33 is an asthma susceptibility gene recently identified through a genetic study of asthmatic families [van Eerdewegh, et al. (2002) Nature 418, 426−430]. To understand the function of the gene product, the recombinant metalloproteinase domain of human ADAM33 was purified and tested for its subst...

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Veröffentlicht in:	Biochemistry (Easton) 2005-03, Vol.44 (11), p.4247-4256
Hauptverfasser:	Zou, Jun, Zhang, Rumin, Zhu, Feng, Liu, Jianjun, Madison, Vincent, Umland, Shelby P
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins Alanine - metabolism Amino Acid Substitution Amyloid beta-Protein Precursor - chemistry Amyloid beta-Protein Precursor - metabolism Calcium Chloride - metabolism Chlorides - metabolism Enzyme Stability Humans Hydrogen-Ion Concentration Hydrolysis Kinetics Metalloendopeptidases - antagonists & inhibitors Metalloendopeptidases - chemistry Metalloendopeptidases - metabolism Models, Molecular Osmolar Concentration Peptide Fragments - chemistry Peptide Fragments - metabolism Protease Inhibitors - chemistry Protein Binding Recombinant Proteins - chemistry Recombinant Proteins - metabolism Sodium Chloride - metabolism Structure-Activity Relationship Substrate Specificity Temperature Zinc Compounds - metabolism
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