Pharmacokinetics of enrofloxacin following intravenous administration to greater rheas: a preliminary study
The pharmacokinetic behaviour of enrofloxacin (ENR) and its active metabolite ciprofloxacin (CIP) were determined in six greater rheas following a single intravenous (i.v.) dose of 15 mg/kg bw. Plasma concentrations of ENR and CIP were simultaneously determined by a HPLC/u.v. method. Following i.v....
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| Veröffentlicht in: | Research in veterinary science 2005-06, Vol.78 (3), p.265-267 |
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| creator | de Lucas, J.J. Rodríguez, C. Martella, M.B. Lábaque, M.C. Navarro, J.L. Andrés, M.I. San |
| description | The pharmacokinetic behaviour of enrofloxacin (ENR) and its active metabolite ciprofloxacin (CIP) were determined in six greater rheas following a single intravenous (i.v.) dose of 15 mg/kg bw. Plasma concentrations of ENR and CIP were simultaneously determined by a HPLC/u.v. method. Following i.v. administration, the plasma drug concentrations were best fitted by an open two-compartment model with a rapid distribution phase. The high volume of distribution (
V
ss
=
5.01 L/Kg) suggests good tissue penetration. ENR presents a high clearance (3.95 L/kg h) explaining the low AUC values (3.57 mg h/L) and a short permanence (t
1/2β
=
2.66 h and MRT
=
1.23 h). Ciprofloxacin comprised 14% of the total fluoroquinolone (ENR
+
CIP). |
| doi_str_mv | 10.1016/j.rvsc.2004.09.007 |
| format | Article |
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V
ss
=
5.01 L/Kg) suggests good tissue penetration. ENR presents a high clearance (3.95 L/kg h) explaining the low AUC values (3.57 mg h/L) and a short permanence (t
1/2β
=
2.66 h and MRT
=
1.23 h). Ciprofloxacin comprised 14% of the total fluoroquinolone (ENR
+
CIP).</description><identifier>ISSN: 0034-5288</identifier><identifier>EISSN: 1532-2661</identifier><identifier>DOI: 10.1016/j.rvsc.2004.09.007</identifier><identifier>PMID: 15766947</identifier><language>eng</language><publisher>England: Elsevier India Pvt Ltd</publisher><subject>Animals ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - blood ; Anti-Bacterial Agents - pharmacokinetics ; Area Under Curve ; Avian ; Behavior ; blood plasma ; Ciprofloxacin ; Ciprofloxacin - blood ; Ciprofloxacin - pharmacokinetics ; dosage ; Drug therapy ; Enrofloxacin ; Fluoroquinolones ; Fluoroquinolones - administration & dosage ; Fluoroquinolones - blood ; Fluoroquinolones - pharmacokinetics ; Half-Life ; high performance liquid chromatography ; Injections, Intravenous - veterinary ; intravenous injection ; Mortality ; Pharmacokinetic ; pharmacokinetics ; Quinolones - administration & dosage ; Quinolones - blood ; Quinolones - pharmacokinetics ; Rhea ; rheas ; Rheiformes - metabolism ; Software packages ; ultraviolet-visible spectroscopy ; Veterinary medicine ; young animals</subject><ispartof>Research in veterinary science, 2005-06, Vol.78 (3), p.265-267</ispartof><rights>2004 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-7ef14db6849dc15956d8500f9b953d843d19ffad291f7221261d0ab0eed835c13</citedby><cites>FETCH-LOGICAL-c406t-7ef14db6849dc15956d8500f9b953d843d19ffad291f7221261d0ab0eed835c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.rvsc.2004.09.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15766947$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Lucas, J.J.</creatorcontrib><creatorcontrib>Rodríguez, C.</creatorcontrib><creatorcontrib>Martella, M.B.</creatorcontrib><creatorcontrib>Lábaque, M.C.</creatorcontrib><creatorcontrib>Navarro, J.L.</creatorcontrib><creatorcontrib>Andrés, M.I. San</creatorcontrib><title>Pharmacokinetics of enrofloxacin following intravenous administration to greater rheas: a preliminary study</title><title>Research in veterinary science</title><addtitle>Res Vet Sci</addtitle><description>The pharmacokinetic behaviour of enrofloxacin (ENR) and its active metabolite ciprofloxacin (CIP) were determined in six greater rheas following a single intravenous (i.v.) dose of 15 mg/kg bw. Plasma concentrations of ENR and CIP were simultaneously determined by a HPLC/u.v. method. Following i.v. administration, the plasma drug concentrations were best fitted by an open two-compartment model with a rapid distribution phase. The high volume of distribution (
V
ss
=
5.01 L/Kg) suggests good tissue penetration. ENR presents a high clearance (3.95 L/kg h) explaining the low AUC values (3.57 mg h/L) and a short permanence (t
1/2β
=
2.66 h and MRT
=
1.23 h). Ciprofloxacin comprised 14% of the total fluoroquinolone (ENR
+
CIP).</description><subject>Animals</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - blood</subject><subject>Anti-Bacterial Agents - pharmacokinetics</subject><subject>Area Under Curve</subject><subject>Avian</subject><subject>Behavior</subject><subject>blood plasma</subject><subject>Ciprofloxacin</subject><subject>Ciprofloxacin - blood</subject><subject>Ciprofloxacin - pharmacokinetics</subject><subject>dosage</subject><subject>Drug therapy</subject><subject>Enrofloxacin</subject><subject>Fluoroquinolones</subject><subject>Fluoroquinolones - administration & dosage</subject><subject>Fluoroquinolones - blood</subject><subject>Fluoroquinolones - pharmacokinetics</subject><subject>Half-Life</subject><subject>high performance liquid chromatography</subject><subject>Injections, Intravenous - veterinary</subject><subject>intravenous injection</subject><subject>Mortality</subject><subject>Pharmacokinetic</subject><subject>pharmacokinetics</subject><subject>Quinolones - administration & dosage</subject><subject>Quinolones - blood</subject><subject>Quinolones - pharmacokinetics</subject><subject>Rhea</subject><subject>rheas</subject><subject>Rheiformes - metabolism</subject><subject>Software packages</subject><subject>ultraviolet-visible spectroscopy</subject><subject>Veterinary medicine</subject><subject>young animals</subject><issn>0034-5288</issn><issn>1532-2661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90U2LFDEQBuAgijuu_gEPGhC8dVtJd9Id8SKLX7CgoHsOmaQym9meZEy6R_ffm2EGBA-eAsVTRaVeQp4zaBkw-Wbb5kOxLQfoW1AtwPCArJjoeMOlZA_JCqDrG8HH8YI8KWULFTI2PCYXTAxSqn5YkbtvtybvjE13IeIcbKHJU4w5-Sn9NjZE6tM0pV8hbmiIczYHjGkp1LhdiKHUwhxSpHOim4xmxkzzLZrylhq6zziFqky-p2Ve3P1T8sibqeCz83tJbj5--HH1ubn--unL1fvrxvYg52ZAz3q3lmOvnGVCCelGAeDVWonOjX3nmPLeOK6YHzhnXDIHZg2IbuyEZd0leX2au8_p54Jl1rtQLE6TiVh313IQrGdKVvjqH7hNS451N82gE9DxsTsqflI2p1Iyer3PYVd_VZE-BqG3-hiEPgahQekaRG16cR69rHfo_racL1_ByxPwJmmzyaHom-8cWAegFPSir-LdSWC91SFg1sUGjBZdyGhn7VL43wZ_AMfypNU</recordid><startdate>20050601</startdate><enddate>20050601</enddate><creator>de Lucas, J.J.</creator><creator>Rodríguez, C.</creator><creator>Martella, M.B.</creator><creator>Lábaque, M.C.</creator><creator>Navarro, J.L.</creator><creator>Andrés, M.I. San</creator><general>Elsevier India Pvt Ltd</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20050601</creationdate><title>Pharmacokinetics of enrofloxacin following intravenous administration to greater rheas: a preliminary study</title><author>de Lucas, J.J. ; Rodríguez, C. ; Martella, M.B. ; Lábaque, M.C. ; Navarro, J.L. ; Andrés, M.I. San</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-7ef14db6849dc15956d8500f9b953d843d19ffad291f7221261d0ab0eed835c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - blood</topic><topic>Anti-Bacterial Agents - pharmacokinetics</topic><topic>Area Under Curve</topic><topic>Avian</topic><topic>Behavior</topic><topic>blood plasma</topic><topic>Ciprofloxacin</topic><topic>Ciprofloxacin - blood</topic><topic>Ciprofloxacin - pharmacokinetics</topic><topic>dosage</topic><topic>Drug therapy</topic><topic>Enrofloxacin</topic><topic>Fluoroquinolones</topic><topic>Fluoroquinolones - administration & dosage</topic><topic>Fluoroquinolones - blood</topic><topic>Fluoroquinolones - pharmacokinetics</topic><topic>Half-Life</topic><topic>high performance liquid chromatography</topic><topic>Injections, Intravenous - veterinary</topic><topic>intravenous injection</topic><topic>Mortality</topic><topic>Pharmacokinetic</topic><topic>pharmacokinetics</topic><topic>Quinolones - administration & dosage</topic><topic>Quinolones - blood</topic><topic>Quinolones - pharmacokinetics</topic><topic>Rhea</topic><topic>rheas</topic><topic>Rheiformes - metabolism</topic><topic>Software packages</topic><topic>ultraviolet-visible spectroscopy</topic><topic>Veterinary medicine</topic><topic>young animals</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Lucas, J.J.</creatorcontrib><creatorcontrib>Rodríguez, C.</creatorcontrib><creatorcontrib>Martella, M.B.</creatorcontrib><creatorcontrib>Lábaque, M.C.</creatorcontrib><creatorcontrib>Navarro, J.L.</creatorcontrib><creatorcontrib>Andrés, M.I. 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San</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacokinetics of enrofloxacin following intravenous administration to greater rheas: a preliminary study</atitle><jtitle>Research in veterinary science</jtitle><addtitle>Res Vet Sci</addtitle><date>2005-06-01</date><risdate>2005</risdate><volume>78</volume><issue>3</issue><spage>265</spage><epage>267</epage><pages>265-267</pages><issn>0034-5288</issn><eissn>1532-2661</eissn><abstract>The pharmacokinetic behaviour of enrofloxacin (ENR) and its active metabolite ciprofloxacin (CIP) were determined in six greater rheas following a single intravenous (i.v.) dose of 15 mg/kg bw. Plasma concentrations of ENR and CIP were simultaneously determined by a HPLC/u.v. method. Following i.v. administration, the plasma drug concentrations were best fitted by an open two-compartment model with a rapid distribution phase. The high volume of distribution (
V
ss
=
5.01 L/Kg) suggests good tissue penetration. ENR presents a high clearance (3.95 L/kg h) explaining the low AUC values (3.57 mg h/L) and a short permanence (t
1/2β
=
2.66 h and MRT
=
1.23 h). Ciprofloxacin comprised 14% of the total fluoroquinolone (ENR
+
CIP).</abstract><cop>England</cop><pub>Elsevier India Pvt Ltd</pub><pmid>15766947</pmid><doi>10.1016/j.rvsc.2004.09.007</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Research in veterinary science, 2005-06, Vol.78 (3), p.265-267 |
| issn | 0034-5288 1532-2661 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - blood Anti-Bacterial Agents - pharmacokinetics Area Under Curve Avian Behavior blood plasma Ciprofloxacin Ciprofloxacin - blood Ciprofloxacin - pharmacokinetics dosage Drug therapy Enrofloxacin Fluoroquinolones Fluoroquinolones - administration & dosage Fluoroquinolones - blood Fluoroquinolones - pharmacokinetics Half-Life high performance liquid chromatography Injections, Intravenous - veterinary intravenous injection Mortality Pharmacokinetic pharmacokinetics Quinolones - administration & dosage Quinolones - blood Quinolones - pharmacokinetics Rhea rheas Rheiformes - metabolism Software packages ultraviolet-visible spectroscopy Veterinary medicine young animals |
| title | Pharmacokinetics of enrofloxacin following intravenous administration to greater rheas: a preliminary study |
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