Accelerated cerebral ischemic injury by activated macrophages/microglia after lipopolysaccharide microinjection into rat corpus callosum

In cerebral ischemic insults, activated inflammatory cells such as microglia and macrophages may be implicated in the pattern and degree of ischemic injury by producing various bioactive mediators. In the present study, we provide the evidence that activated microglia/macrophages accelerate cerebral...

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Veröffentlicht in:	Glia 2005-04, Vol.50 (2), p.168-181
Hauptverfasser:	Lee, Jae-Chul, Cho, Geum-Sil, Kim, Hye Jin, Lim, Ji-Hye, Oh, Yu-Kyoung, Nam, Wonwoo, Chung, Jang-Hyun, Kim, Won-Ki
Format:	Artikel
Sprache:	eng
Schlagworte:	accelerated cerebral ischemic injury activated macrophages/microglia Animals Brain Ischemia - pathology Corpus Callosum - physiology Enzyme Inhibitors - pharmacology Fluoresceins Fluorescent Dyes Glutathione - metabolism Immunohistochemistry Infarction, Middle Cerebral Artery - pathology Lipopolysaccharides - administration & dosage Lipopolysaccharides - pharmacology LPS Macrophage Activation - physiology Macrophages - physiology Male Microglia - physiology Microinjections Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase Type II Organic Chemicals rat corpus callosum Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis RNA, Messenger - genetics Tyrosine - analogs & derivatives Tyrosine - pharmacology
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