Toll-like receptor 2 stimulation induces intimal hyperplasia and atherosclerotic lesion development

Toll like receptors (Tlr) are essential in activation of the innate immune system. We recently described that peptidoglycan, an exogenous Tlr2 specific ligand, is present in human atherosclerotic plaques and associated with histological markers for plaque vulnerability. Also, endogenous Tlr2 ligands...

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Veröffentlicht in:	Cardiovascular research 2005-04, Vol.66 (1), p.162-169
Hauptverfasser:	SCHONEVELD, A. H, OUDE NIJHUIS, M. M, VAN MIDDELAAR, B, LAMAN, J. D, DE KLEIJN, D. P. V, PASTERKAMP, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoproteins E - genetics Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blotting, Western - methods Cardiology. Vascular system Chemokine CCL2 - analysis Chemokine CCL2 - genetics Coronary Artery Disease - immunology Fibroblasts - immunology Humans Interleukin-1 - analysis Interleukin-1 - genetics Interleukin-6 - analysis Interleukin-6 - genetics Interleukin-8 - analysis Interleukin-8 - genetics Ligands Lipoproteins - pharmacology Medical sciences Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout Neovascularization, Pathologic - chemically induced Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Toll-Like Receptor 2 Toll-Like Receptors Tunica Intima - drug effects Tunica Intima - pathology
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