A 2-Aminobenzimidazole That Inhibits and Disperses Gram-Positive Biofilms through a Zinc-Dependent Mechanism

A number of 2-aminobenzimidazole derivatives were synthesized and screened for their ability to inhibit and disperse bacterial biofilms. From these compounds, a lead 2-aminobenzimidazole was identified that both inhibited and dispersed MRSA, vancomycin-resistant Enterococcus faecium, and Staphylococ...

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Veröffentlicht in:	Journal of the American Chemical Society 2009-07, Vol.131 (29), p.9868-9869
Hauptverfasser:	Rogers, Steven A, Huigens III, Robert W, Melander, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzimidazoles - chemical synthesis Benzimidazoles - chemistry Benzimidazoles - pharmacology Biofilms - drug effects Biofilms - growth & development Dose-Response Relationship, Drug Gram-Positive Bacteria - drug effects Magnetic Resonance Spectroscopy Molecular Structure Structure-Activity Relationship Zinc - chemistry Zinc - pharmacology
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