Targeting the platelet-derived growth factor receptor α with a neutralizing human monoclonal antibody inhibits the growth of tumor xenografts: Implications as a potential therapeutic target

Platelet-derived growth factor receptor α (PDGFRα) is a type III receptor tyrosine kinase that is expressed on a variety of tumor types. A neutralizing monoclonal antibody to human PDGFRα, which did not cross-react with the β form of the receptor, was generated. The fully human antibody, termed 3G3,...

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Veröffentlicht in:	Molecular cancer therapeutics 2005-03, Vol.4 (3), p.369-379
Hauptverfasser:	Loizos, Nick, Xu, Yan, Huber, Jim, Liu, Meilin, Lu, Dan, Finnerty, Bridget, Rolser, Robin, Malikzay, Asra, Persaud, Anita, Corcoran, Erik, Deevi, Dhanvanthri S, Balderes, Paul, Bassi, Rajiv, Jimenez, Xenia, Joynes, Christopher J, Mangalampalli, Venkata R M, Steiner, Philipp, Tonra, James R, Wu, Yan, Pereira, Daniel S, Zhu, Zhenping, Ludwig, Dale L, Hicklin, Daniel J, Bohlen, Peter, Witte, Larry, Kussie, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - chemistry Biological Assay Cell Line, Tumor Dose-Response Relationship, Immunologic Flow Cytometry Humans Kinetics Ligands MAP Kinase Signaling System Mice Mice, Nude Mice, Transgenic monoclonal antibody Neoplasm Transplantation Phosphorylation Platelet-Derived Growth Factor - chemistry Platelet-derived growth factor receptor Protein Binding Protein Structure, Tertiary Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Proto-Oncogene Proteins c-sis Receptor, Platelet-Derived Growth Factor alpha - immunology Receptor, Platelet-Derived Growth Factor alpha - metabolism stroma therapeutic Time Factors Transfection xenograft
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