A New Synthesis of 2-Substituted Pyridines via Aluminum Chloride Induced Heteroarylation of Arenes and Heteroarenes

We herein report a new synthesis of 2-(hetero)aryl-substituted pyridines via heteroarylation of arenes/heteroarenes through AlCl3-induced C−C bond-forming reactions. 2-Halopyridines bearing an electron-withdrawing group were reacted with a number of (hetero)arenes to give 2-aryl/heteroaryl-substitut...

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Veröffentlicht in:	Journal of organic chemistry 2005-03, Vol.70 (6), p.2376-2379
Hauptverfasser:	Pal, Manojit, Batchu, Venkateswara Rao, Dager, Indu, Swamy, Nalivela Kumara, Padakanti, Srinivas
Format:	Artikel
Sprache:	eng
Schlagworte:	Aluminum Compounds - chemistry Chemistry Chlorides - chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Molecular Structure Organic chemistry Preparations and properties Pyridines - chemical synthesis Pyridines - chemistry
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Beschreibung
Zusammenfassung:	We herein report a new synthesis of 2-(hetero)aryl-substituted pyridines via heteroarylation of arenes/heteroarenes through AlCl3-induced C−C bond-forming reactions. 2-Halopyridines bearing an electron-withdrawing group were reacted with a number of (hetero)arenes to give 2-aryl/heteroaryl-substituted pyridines in good yields.
ISSN:	0022-3263 1520-6904
DOI:	10.1021/jo047944h