Arabidopsis DOF Transcription Factors Act Redundantly to Reduce CONSTANS Expression and Are Essential for a Photoperiodic Flowering Response
Flowering of Arabidopsis is induced by long summer days (LDs). The transcriptional regulator CONSTANS (CO) promotes flowering, and its transcription is increased under LDs. We systematically misexpressed transcription factors in companion cells and identified several DOF proteins that delay flowerin...
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| Veröffentlicht in: | Developmental cell 2009-07, Vol.17 (1), p.75-86 |
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| creator | Fornara, Fabio Panigrahi, Kishore C.S. Gissot, Lionel Sauerbrunn, Nicolas Rühl, Mark Jarillo, José A. Coupland, George |
| description | Flowering of Arabidopsis is induced by long summer days (LDs). The transcriptional regulator CONSTANS (CO) promotes flowering, and its transcription is increased under LDs. We systematically misexpressed transcription factors in companion cells and identified several DOF proteins that delay flowering by repressing CO transcription. Combining mutations in four of these, including CYCLING DOF FACTOR 2 (CDF2), caused photoperiod-insensitive early flowering by increasing CO mRNA levels. CO transcription is promoted to differing extents by GIGANTEA (GI) and the F-box protein FKF1. We show that GI stabilizes FKF1, thereby reducing CDF2 abundance and allowing transcription of CO. Despite the crucial function of GI in wild-type plants, introducing mutations in the four DOF-encoding genes into gi mutants restored the diurnal rhythm and light inducibility of CO. Thus, antagonism between GI and DOF transcription factors contributes to photoperiodic flowering by modulating an underlying diurnal rhythm in CO transcript levels. |
| doi_str_mv | 10.1016/j.devcel.2009.06.015 |
| format | Article |
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The transcriptional regulator CONSTANS (CO) promotes flowering, and its transcription is increased under LDs. We systematically misexpressed transcription factors in companion cells and identified several DOF proteins that delay flowering by repressing CO transcription. Combining mutations in four of these, including CYCLING DOF FACTOR 2 (CDF2), caused photoperiod-insensitive early flowering by increasing CO mRNA levels. CO transcription is promoted to differing extents by GIGANTEA (GI) and the F-box protein FKF1. We show that GI stabilizes FKF1, thereby reducing CDF2 abundance and allowing transcription of CO. Despite the crucial function of GI in wild-type plants, introducing mutations in the four DOF-encoding genes into gi mutants restored the diurnal rhythm and light inducibility of CO. Thus, antagonism between GI and DOF transcription factors contributes to photoperiodic flowering by modulating an underlying diurnal rhythm in CO transcript levels.</description><identifier>ISSN: 1534-5807</identifier><identifier>EISSN: 1878-1551</identifier><identifier>DOI: 10.1016/j.devcel.2009.06.015</identifier><identifier>PMID: 19619493</identifier><language>eng</language><publisher>Cambridge, MA: Elsevier Inc</publisher><subject>Arabidopsis - anatomy & histology ; Arabidopsis - genetics ; Arabidopsis - physiology ; Arabidopsis Proteins - genetics ; Arabidopsis Proteins - metabolism ; Biological and medical sciences ; Cell differentiation, maturation, development, hematopoiesis ; Cell physiology ; Circadian Rhythm - physiology ; DEVBIO ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Flowers - physiology ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation, Plant ; Molecular and cellular biology ; Mutation ; Photoperiod ; Plants, Genetically Modified ; Repressor Proteins - genetics ; Repressor Proteins - metabolism ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Signal Transduction - physiology ; Transcription Factors - genetics ; Transcription Factors - metabolism</subject><ispartof>Developmental cell, 2009-07, Vol.17 (1), p.75-86</ispartof><rights>2009 Elsevier Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c553t-a8302b94f6949c1a55a88ccf89097f901dfb72ee51a358c9df8261ef2e4515433</citedby><cites>FETCH-LOGICAL-c553t-a8302b94f6949c1a55a88ccf89097f901dfb72ee51a358c9df8261ef2e4515433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.devcel.2009.06.015$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21778363$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19619493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fornara, Fabio</creatorcontrib><creatorcontrib>Panigrahi, Kishore C.S.</creatorcontrib><creatorcontrib>Gissot, Lionel</creatorcontrib><creatorcontrib>Sauerbrunn, Nicolas</creatorcontrib><creatorcontrib>Rühl, Mark</creatorcontrib><creatorcontrib>Jarillo, José A.</creatorcontrib><creatorcontrib>Coupland, George</creatorcontrib><title>Arabidopsis DOF Transcription Factors Act Redundantly to Reduce CONSTANS Expression and Are Essential for a Photoperiodic Flowering Response</title><title>Developmental cell</title><addtitle>Dev Cell</addtitle><description>Flowering of Arabidopsis is induced by long summer days (LDs). The transcriptional regulator CONSTANS (CO) promotes flowering, and its transcription is increased under LDs. We systematically misexpressed transcription factors in companion cells and identified several DOF proteins that delay flowering by repressing CO transcription. Combining mutations in four of these, including CYCLING DOF FACTOR 2 (CDF2), caused photoperiod-insensitive early flowering by increasing CO mRNA levels. CO transcription is promoted to differing extents by GIGANTEA (GI) and the F-box protein FKF1. We show that GI stabilizes FKF1, thereby reducing CDF2 abundance and allowing transcription of CO. Despite the crucial function of GI in wild-type plants, introducing mutations in the four DOF-encoding genes into gi mutants restored the diurnal rhythm and light inducibility of CO. Thus, antagonism between GI and DOF transcription factors contributes to photoperiodic flowering by modulating an underlying diurnal rhythm in CO transcript levels.</description><subject>Arabidopsis - anatomy & histology</subject><subject>Arabidopsis - genetics</subject><subject>Arabidopsis - physiology</subject><subject>Arabidopsis Proteins - genetics</subject><subject>Arabidopsis Proteins - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cell differentiation, maturation, development, hematopoiesis</subject><subject>Cell physiology</subject><subject>Circadian Rhythm - physiology</subject><subject>DEVBIO</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Flowers - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Plant</subject><subject>Molecular and cellular biology</subject><subject>Mutation</subject><subject>Photoperiod</subject><subject>Plants, Genetically Modified</subject><subject>Repressor Proteins - genetics</subject><subject>Repressor Proteins - metabolism</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Signal Transduction - physiology</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><issn>1534-5807</issn><issn>1878-1551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUGP0zAQhSMEYpeFf4CQL3BLsJM4sS9IUbcFpNUWseVsufYYXKV28KQL-x_40bi0ghsnj6XvPc28VxQvGa0YZd3bXWXh3sBY1ZTKinYVZfxRcclEL0rGOXucZ960JRe0vyieIe5oljFBnxYXTHZMtrK5LH4NSW-9jRN6JNfrFdkkHdAkP80-BrLSZo4JyWBm8hnsIVgd5vGBzPHP1wBZrG_vNsPtHVn-nBIgHlU6WDIkIEtECLPXI3ExEU0-fYtznCD5aL0hqzH-yHP4mq1wigHhefHE6RHhxfm9Kr6slpvFh_Jm_f7jYrgpDefNXGrR0HorW9flGwzTnGshjHFCUtk7SZl1274G4Ew3XBhpnag7Bq6GljPeNs1V8ebkO6X4_QA4q73HHOWoA8QDqq7nVNSyzWB7Ak2KiAmcmpLf6_SgGFXHFtROnVpQxxYU7VRuIctenf0P2z3Yf6Jz7Bl4fQY0Gj26nLnx-JerWd-Lpjty704c5DTuPSSFxkMwYH0CMysb_f83-Q02GaiV</recordid><startdate>200907</startdate><enddate>200907</enddate><creator>Fornara, Fabio</creator><creator>Panigrahi, Kishore C.S.</creator><creator>Gissot, Lionel</creator><creator>Sauerbrunn, Nicolas</creator><creator>Rühl, Mark</creator><creator>Jarillo, José A.</creator><creator>Coupland, George</creator><general>Elsevier Inc</general><general>Cell Press</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200907</creationdate><title>Arabidopsis DOF Transcription Factors Act Redundantly to Reduce CONSTANS Expression and Are Essential for a Photoperiodic Flowering Response</title><author>Fornara, Fabio ; Panigrahi, Kishore C.S. ; Gissot, Lionel ; Sauerbrunn, Nicolas ; Rühl, Mark ; Jarillo, José A. ; Coupland, George</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c553t-a8302b94f6949c1a55a88ccf89097f901dfb72ee51a358c9df8261ef2e4515433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Arabidopsis - anatomy & histology</topic><topic>Arabidopsis - genetics</topic><topic>Arabidopsis - physiology</topic><topic>Arabidopsis Proteins - genetics</topic><topic>Arabidopsis Proteins - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cell differentiation, maturation, development, hematopoiesis</topic><topic>Cell physiology</topic><topic>Circadian Rhythm - physiology</topic><topic>DEVBIO</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Flowers - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation, Plant</topic><topic>Molecular and cellular biology</topic><topic>Mutation</topic><topic>Photoperiod</topic><topic>Plants, Genetically Modified</topic><topic>Repressor Proteins - genetics</topic><topic>Repressor Proteins - metabolism</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Signal Transduction - physiology</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fornara, Fabio</creatorcontrib><creatorcontrib>Panigrahi, Kishore C.S.</creatorcontrib><creatorcontrib>Gissot, Lionel</creatorcontrib><creatorcontrib>Sauerbrunn, Nicolas</creatorcontrib><creatorcontrib>Rühl, Mark</creatorcontrib><creatorcontrib>Jarillo, José A.</creatorcontrib><creatorcontrib>Coupland, George</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fornara, Fabio</au><au>Panigrahi, Kishore C.S.</au><au>Gissot, Lionel</au><au>Sauerbrunn, Nicolas</au><au>Rühl, Mark</au><au>Jarillo, José A.</au><au>Coupland, George</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Arabidopsis DOF Transcription Factors Act Redundantly to Reduce CONSTANS Expression and Are Essential for a Photoperiodic Flowering Response</atitle><jtitle>Developmental cell</jtitle><addtitle>Dev Cell</addtitle><date>2009-07</date><risdate>2009</risdate><volume>17</volume><issue>1</issue><spage>75</spage><epage>86</epage><pages>75-86</pages><issn>1534-5807</issn><eissn>1878-1551</eissn><abstract>Flowering of Arabidopsis is induced by long summer days (LDs). The transcriptional regulator CONSTANS (CO) promotes flowering, and its transcription is increased under LDs. We systematically misexpressed transcription factors in companion cells and identified several DOF proteins that delay flowering by repressing CO transcription. Combining mutations in four of these, including CYCLING DOF FACTOR 2 (CDF2), caused photoperiod-insensitive early flowering by increasing CO mRNA levels. CO transcription is promoted to differing extents by GIGANTEA (GI) and the F-box protein FKF1. We show that GI stabilizes FKF1, thereby reducing CDF2 abundance and allowing transcription of CO. Despite the crucial function of GI in wild-type plants, introducing mutations in the four DOF-encoding genes into gi mutants restored the diurnal rhythm and light inducibility of CO. 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| source | MEDLINE; Cell Press Free Archives; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals |
| subjects | Arabidopsis - anatomy & histology Arabidopsis - genetics Arabidopsis - physiology Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell physiology Circadian Rhythm - physiology DEVBIO DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Flowers - physiology Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Plant Molecular and cellular biology Mutation Photoperiod Plants, Genetically Modified Repressor Proteins - genetics Repressor Proteins - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction - physiology Transcription Factors - genetics Transcription Factors - metabolism |
| title | Arabidopsis DOF Transcription Factors Act Redundantly to Reduce CONSTANS Expression and Are Essential for a Photoperiodic Flowering Response |
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