Factors Predicting Successful Labor Induction With Dinoprostone and Misoprostol Vaginal Inserts
To evaluate the maternal and pregnancy characteristics that independently predict successful induction of labor, defined as vaginal delivery. The study was a secondary analysis of the data collected during the Misoprostol Vaginal Insert Trial, a multisite, double-blind, randomized trial of women req...
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Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 2009-08, Vol.114 (2), p.261-267 |
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creator | Pevzner, Leo Rayburn, William F. Rumney, Pamela Wing, Deborah A. |
description | To evaluate the maternal and pregnancy characteristics that independently predict successful induction of labor, defined as vaginal delivery.
The study was a secondary analysis of the data collected during the Misoprostol Vaginal Insert Trial, a multisite, double-blind, randomized trial of women requiring cervical ripening before induction of labor. The primary outcome was to estimate the maternal and pregnancy characteristics that independently predict successful induction of labor. Univariable and multiple regression analyses were performed for maternal and pregnancy-related factors that potentially could predict a successful induction of labor.
A total of 1,274 patients had sufficient labor and delivery data for a comparative analysis. Nine hundred sixteen (72%) induced patients subsequently had vaginal deliveries. Multiparity (odds ratio [OR] 4.63, 95% confidence interval [CI] 3.39-6.32, P |
doi_str_mv | 10.1097/AOG.0b013e3181ad9377 |
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The study was a secondary analysis of the data collected during the Misoprostol Vaginal Insert Trial, a multisite, double-blind, randomized trial of women requiring cervical ripening before induction of labor. The primary outcome was to estimate the maternal and pregnancy characteristics that independently predict successful induction of labor. Univariable and multiple regression analyses were performed for maternal and pregnancy-related factors that potentially could predict a successful induction of labor.
A total of 1,274 patients had sufficient labor and delivery data for a comparative analysis. Nine hundred sixteen (72%) induced patients subsequently had vaginal deliveries. Multiparity (odds ratio [OR] 4.63, 95% confidence interval [CI] 3.39-6.32, P<.001), maternal body mass index (BMI) less than 30 (OR 1.69, 95% CI 1.32-2.22, P<.001) and height greater than 5'5" (OR 1.47, 95% CI 1.15-1.9, P=.002), baseline modified Bishop score of 4 (OR 2.15, 95% CI 1.12-4.20, P=.047), and birth weight below 4,000 g (OR 2.17, 95% CI 1.51-3.13, P<.001) were significant for predicting successful induction of labor. Logistic regression analysis was performed to evaluate each factor as an independent predictor. In addition to the above-mentioned factors, maternal age younger than 35 years (OR 1.81, 95% CI 1.15-2.86, P=.01) and Hispanic race (OR 1.45, 95% CI 1.02-2.05, P=.036) each proved to significantly favor a successful induction. Conversely, African-American race was correlated with a higher incidence of cesarean delivery (OR 1.47, 95% CI 1.02-2.13, P<.001).
Maternal characteristics such as BMI, parity, age, and race and neonatal birth weight are important variables to consider when predicting a successful induction of labor. The nearly 30% rate of cesarean delivery in this study underscores the importance of selecting appropriate candidates.
II.</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>DOI: 10.1097/AOG.0b013e3181ad9377</identifier><identifier>PMID: 19622986</identifier><identifier>CODEN: OBGNAS</identifier><language>eng</language><publisher>Hagerstown, MD: by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Adult ; Biological and medical sciences ; Birth Weight ; Body Height ; Body Mass Index ; Continental Population Groups ; Delivery. Postpartum. Lactation ; Digestive system ; Dinoprostone - administration & dosage ; Double-Blind Method ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Infant, Newborn ; Labor, Induced - methods ; Maternal Age ; Medical sciences ; Misoprostol - administration & dosage ; Oxytocics - administration & dosage ; Parity ; Pharmacology. Drug treatments ; Pregnancy ; Suppositories ; Vagina</subject><ispartof>Obstetrics and gynecology (New York. 1953), 2009-08, Vol.114 (2), p.261-267</ispartof><rights>by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3801-17ca506f0e5c9ed8913f28b019ffa627dacd26b42cacdbfa52e86166fb231933</citedby><cites>FETCH-LOGICAL-c3801-17ca506f0e5c9ed8913f28b019ffa627dacd26b42cacdbfa52e86166fb231933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21790241$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19622986$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pevzner, Leo</creatorcontrib><creatorcontrib>Rayburn, William F.</creatorcontrib><creatorcontrib>Rumney, Pamela</creatorcontrib><creatorcontrib>Wing, Deborah A.</creatorcontrib><title>Factors Predicting Successful Labor Induction With Dinoprostone and Misoprostol Vaginal Inserts</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>To evaluate the maternal and pregnancy characteristics that independently predict successful induction of labor, defined as vaginal delivery.
The study was a secondary analysis of the data collected during the Misoprostol Vaginal Insert Trial, a multisite, double-blind, randomized trial of women requiring cervical ripening before induction of labor. The primary outcome was to estimate the maternal and pregnancy characteristics that independently predict successful induction of labor. Univariable and multiple regression analyses were performed for maternal and pregnancy-related factors that potentially could predict a successful induction of labor.
A total of 1,274 patients had sufficient labor and delivery data for a comparative analysis. Nine hundred sixteen (72%) induced patients subsequently had vaginal deliveries. Multiparity (odds ratio [OR] 4.63, 95% confidence interval [CI] 3.39-6.32, P<.001), maternal body mass index (BMI) less than 30 (OR 1.69, 95% CI 1.32-2.22, P<.001) and height greater than 5'5" (OR 1.47, 95% CI 1.15-1.9, P=.002), baseline modified Bishop score of 4 (OR 2.15, 95% CI 1.12-4.20, P=.047), and birth weight below 4,000 g (OR 2.17, 95% CI 1.51-3.13, P<.001) were significant for predicting successful induction of labor. Logistic regression analysis was performed to evaluate each factor as an independent predictor. In addition to the above-mentioned factors, maternal age younger than 35 years (OR 1.81, 95% CI 1.15-2.86, P=.01) and Hispanic race (OR 1.45, 95% CI 1.02-2.05, P=.036) each proved to significantly favor a successful induction. Conversely, African-American race was correlated with a higher incidence of cesarean delivery (OR 1.47, 95% CI 1.02-2.13, P<.001).
Maternal characteristics such as BMI, parity, age, and race and neonatal birth weight are important variables to consider when predicting a successful induction of labor. The nearly 30% rate of cesarean delivery in this study underscores the importance of selecting appropriate candidates.
II.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Birth Weight</subject><subject>Body Height</subject><subject>Body Mass Index</subject><subject>Continental Population Groups</subject><subject>Delivery. Postpartum. Lactation</subject><subject>Digestive system</subject><subject>Dinoprostone - administration & dosage</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Labor, Induced - methods</subject><subject>Maternal Age</subject><subject>Medical sciences</subject><subject>Misoprostol - administration & dosage</subject><subject>Oxytocics - administration & dosage</subject><subject>Parity</subject><subject>Pharmacology. Drug treatments</subject><subject>Pregnancy</subject><subject>Suppositories</subject><subject>Vagina</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV1PFTEQhhsjkSP4D4zZG71bnGl3-3FJUJDkGEgg6l3T7bacak8X290Q_70lbCTxajrt885M3yHkLcIJghIfT68uTmAAZI6hRDMqJsQLskEpWEsZ-_GSbACoaoXsukPyupSfAIBcsVfkEBWnVEm-Ifrc2HnKpbnObgx2DumuuVmsdaX4JTZbM0y5uUzjUp-m1HwP8675FNJ0n6cyT8k1Jo3N11DWi9h8M3chmVg1xeW5HJMDb2Jxb9Z4RG7PP9-efWm3VxeXZ6fb1jIJ2KKwpgfuwfVWuVEqZJ7K-jvlveFUjMaOlA8dtfUweNNTJzly7gfKUDF2RD48la1j_F5cmfU-FOtiNMlNS9Fc9CBRqQp2T6Ct85bsvL7PYW_yH42gH33V1Vf9v69V9m6tvwx7Nz6LViMr8H4FTLEm-mySDeUfR1EooB0-93-Y4uxy-RWXB5f1zpk473TdEHDaQ0sBFMiatY9LQ_YX9lSS4g</recordid><startdate>20090801</startdate><enddate>20090801</enddate><creator>Pevzner, Leo</creator><creator>Rayburn, William F.</creator><creator>Rumney, Pamela</creator><creator>Wing, Deborah A.</creator><general>by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090801</creationdate><title>Factors Predicting Successful Labor Induction With Dinoprostone and Misoprostol Vaginal Inserts</title><author>Pevzner, Leo ; Rayburn, William F. ; Rumney, Pamela ; Wing, Deborah A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3801-17ca506f0e5c9ed8913f28b019ffa627dacd26b42cacdbfa52e86166fb231933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Birth Weight</topic><topic>Body Height</topic><topic>Body Mass Index</topic><topic>Continental Population Groups</topic><topic>Delivery. Postpartum. Lactation</topic><topic>Digestive system</topic><topic>Dinoprostone - administration & dosage</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Labor, Induced - methods</topic><topic>Maternal Age</topic><topic>Medical sciences</topic><topic>Misoprostol - administration & dosage</topic><topic>Oxytocics - administration & dosage</topic><topic>Parity</topic><topic>Pharmacology. Drug treatments</topic><topic>Pregnancy</topic><topic>Suppositories</topic><topic>Vagina</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pevzner, Leo</creatorcontrib><creatorcontrib>Rayburn, William F.</creatorcontrib><creatorcontrib>Rumney, Pamela</creatorcontrib><creatorcontrib>Wing, Deborah A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pevzner, Leo</au><au>Rayburn, William F.</au><au>Rumney, Pamela</au><au>Wing, Deborah A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors Predicting Successful Labor Induction With Dinoprostone and Misoprostol Vaginal Inserts</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>2009-08-01</date><risdate>2009</risdate><volume>114</volume><issue>2</issue><spage>261</spage><epage>267</epage><pages>261-267</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><coden>OBGNAS</coden><abstract>To evaluate the maternal and pregnancy characteristics that independently predict successful induction of labor, defined as vaginal delivery.
The study was a secondary analysis of the data collected during the Misoprostol Vaginal Insert Trial, a multisite, double-blind, randomized trial of women requiring cervical ripening before induction of labor. The primary outcome was to estimate the maternal and pregnancy characteristics that independently predict successful induction of labor. Univariable and multiple regression analyses were performed for maternal and pregnancy-related factors that potentially could predict a successful induction of labor.
A total of 1,274 patients had sufficient labor and delivery data for a comparative analysis. Nine hundred sixteen (72%) induced patients subsequently had vaginal deliveries. Multiparity (odds ratio [OR] 4.63, 95% confidence interval [CI] 3.39-6.32, P<.001), maternal body mass index (BMI) less than 30 (OR 1.69, 95% CI 1.32-2.22, P<.001) and height greater than 5'5" (OR 1.47, 95% CI 1.15-1.9, P=.002), baseline modified Bishop score of 4 (OR 2.15, 95% CI 1.12-4.20, P=.047), and birth weight below 4,000 g (OR 2.17, 95% CI 1.51-3.13, P<.001) were significant for predicting successful induction of labor. Logistic regression analysis was performed to evaluate each factor as an independent predictor. In addition to the above-mentioned factors, maternal age younger than 35 years (OR 1.81, 95% CI 1.15-2.86, P=.01) and Hispanic race (OR 1.45, 95% CI 1.02-2.05, P=.036) each proved to significantly favor a successful induction. Conversely, African-American race was correlated with a higher incidence of cesarean delivery (OR 1.47, 95% CI 1.02-2.13, P<.001).
Maternal characteristics such as BMI, parity, age, and race and neonatal birth weight are important variables to consider when predicting a successful induction of labor. The nearly 30% rate of cesarean delivery in this study underscores the importance of selecting appropriate candidates.
II.</abstract><cop>Hagerstown, MD</cop><pub>by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>19622986</pmid><doi>10.1097/AOG.0b013e3181ad9377</doi><tpages>7</tpages></addata></record> |
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subjects | Adult Biological and medical sciences Birth Weight Body Height Body Mass Index Continental Population Groups Delivery. Postpartum. Lactation Digestive system Dinoprostone - administration & dosage Double-Blind Method Female Gynecology. Andrology. Obstetrics Humans Infant, Newborn Labor, Induced - methods Maternal Age Medical sciences Misoprostol - administration & dosage Oxytocics - administration & dosage Parity Pharmacology. Drug treatments Pregnancy Suppositories Vagina |
title | Factors Predicting Successful Labor Induction With Dinoprostone and Misoprostol Vaginal Inserts |
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