Evidence for the Presence of Protease-Activated Receptor 2 and Its Possible Implication in Remodeling of Human Endometrium

Protease-activated receptor 2 (PAR2) is activated by various proteases released from the leukocytes, such as neutrophils and mast cells. Because these leukocytes reside in the endometrium, we speculated that PAR2 might be activated there. In this study, we investigated the presence and possible role...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2005-03, Vol.90 (3), p.1662-1669
Hauptverfasser:	Hirota, Yasushi, Osuga, Yutaka, Hirata, Tetsuya, Koga, Kaori, Yoshino, Osamu, Harada, Miyuki, Morimoto, Chieko, Nose, Emi, Yano, Tetsu, Tsutsumi, Osamu, Taketani, Yuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Cell Division - physiology Cells, Cultured Endocrinopathies Endometrium - cytology Endometrium - physiology Enzyme Inhibitors - pharmacology Epithelial Cells - cytology Epithelial Cells - physiology Epithelial Cells - secretion Female Fundamental and applied biological sciences. Psychology Gene Expression - physiology Humans Interleukin-8 - metabolism Interleukin-8 - secretion Matrix Metalloproteinase 7 - metabolism Medical sciences Menstrual Cycle - physiology Middle Aged Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Phosphorylation Receptor, PAR-2 - genetics Receptor, PAR-2 - metabolism RNA, Messenger - analysis Stem Cell Factor - genetics Stromal Cells - cytology Stromal Cells - physiology Stromal Cells - secretion Vertebrates: endocrinology
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