Cognitive functioning after repetitive transcranial magnetic stimulation in patients with cerebrovascular disease without dementia: a pilot study of seven patients
Examine whether one session of high frequency repetitive transcranial magnetic stimulation (rTMS) applied over the left dorsolateral prefrontal cortex (DLPFC) would induce any measurable cognitive changes in patients with cerebrovascular disease and mild cognitive deficits. Seven patients with cereb...
Gespeichert in:
| Veröffentlicht in: | Journal of the neurological sciences 2005-03, Vol.229, p.157-161 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 161 |
|---|---|
| container_issue | |
| container_start_page | 157 |
| container_title | Journal of the neurological sciences |
| container_volume | 229 |
| creator | Rektorova, I. Megova, S. Bares, M. Rektor, I. |
| description | Examine whether one session of high frequency repetitive transcranial magnetic stimulation (rTMS) applied over the left dorsolateral prefrontal cortex (DLPFC) would induce any measurable cognitive changes in patients with cerebrovascular disease and mild cognitive deficits.
Seven patients with cerebrovascular disease and mild executive dysfunction entered the randomised, controlled, blinded study with a crossover design. rTMS was applied either over the left DLPFC (an active stimulation site) or over the left motor cortex (MC; a control stimulation site) in one session. Each patient participated in both stimulation sessions (days 1 and 4) and the order of stimulation sites (DLPFC or MC) was randomised. A short battery of neuropsychological tests was performed by a blinded psychologist prior to and after each rTMS session. Psychomotor speed, executive function, and memory were evaluated.
The only mild but significant stimulation site-specific effect of rTMS was observed in the Stroop interference results (i.e. improvement) after the stimulation of DLPFC but not MC in comparison with the baseline scores (Wilcoxon,
Z=−2.03,
p=0.04). Patients improved in the digit symbols subtest of the Wechsler adult intelligence scale-revised after both rTMS sessions regardless of the stimulation site (DLPFC or MC;
Z=−2.06,
p=0.04 and
Z=−2.06,
p=0.04, respectively). There was no measurable effect of rTMS in any other neuropsychological test.
Our pilot study results showed that one session of the high frequency rTMS applied over the left DLPFC was safe in patients with cerebrovascular disease and mild executive deficits, and may induce measurable positive effects on executive functioning. |
| doi_str_mv | 10.1016/j.jns.2004.11.021 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67506965</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022510X04004447</els_id><sourcerecordid>67506965</sourcerecordid><originalsourceid>FETCH-LOGICAL-c351t-dcabea6cf904af5d2ed744eebb29eac8691c854635b034d188960c5aeaf19d0c3</originalsourceid><addsrcrecordid>eNp9kb1u2zAUhTk0aH6aB8hScMpm5VIWaauZAiNtCgTo0gLdiCvyyqUhkQpJucjz9EVL1waydSEJnO8c4PAwdiOgEiDU3a7a-VTVAE0lRAW1eMcuAOp6IQX8PGeXKe0AQK3X7Xt2LuRKgVrKC_ZnE7beZbcn3s_eZBe881uOfabII02Uj2KO6JMph8OBj7j1RTA8ZTfOAx5c3Hk-lRf5nPhvl39xQ5G6GPaYTGEity4RJvonhjlzS2OBHX7iyCc3hFziZvvKQ88T7ekt7gM763FIdH26r9iPz4_fN0-L529fvm4enhdmKUVeWIMdoTJ9Cw320tZkV01D1HV1S2jWqhVmLZtSu4NlY0X5CgVGImEvWgtmecVuj7lTDC8zpaxHlwwNA3oKc9JqJUG1ShZQHEETQ0qRej1FN2J81QL0YQ2902UNfVhDC6HLGsXz8RQ-dyPZN8dpigLcHwEqFfeOok6m1DdkXSSTtQ3uP_F_AXtPo6I</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67506965</pqid></control><display><type>article</type><title>Cognitive functioning after repetitive transcranial magnetic stimulation in patients with cerebrovascular disease without dementia: a pilot study of seven patients</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Rektorova, I. ; Megova, S. ; Bares, M. ; Rektor, I.</creator><creatorcontrib>Rektorova, I. ; Megova, S. ; Bares, M. ; Rektor, I.</creatorcontrib><description>Examine whether one session of high frequency repetitive transcranial magnetic stimulation (rTMS) applied over the left dorsolateral prefrontal cortex (DLPFC) would induce any measurable cognitive changes in patients with cerebrovascular disease and mild cognitive deficits.
Seven patients with cerebrovascular disease and mild executive dysfunction entered the randomised, controlled, blinded study with a crossover design. rTMS was applied either over the left DLPFC (an active stimulation site) or over the left motor cortex (MC; a control stimulation site) in one session. Each patient participated in both stimulation sessions (days 1 and 4) and the order of stimulation sites (DLPFC or MC) was randomised. A short battery of neuropsychological tests was performed by a blinded psychologist prior to and after each rTMS session. Psychomotor speed, executive function, and memory were evaluated.
The only mild but significant stimulation site-specific effect of rTMS was observed in the Stroop interference results (i.e. improvement) after the stimulation of DLPFC but not MC in comparison with the baseline scores (Wilcoxon,
Z=−2.03,
p=0.04). Patients improved in the digit symbols subtest of the Wechsler adult intelligence scale-revised after both rTMS sessions regardless of the stimulation site (DLPFC or MC;
Z=−2.06,
p=0.04 and
Z=−2.06,
p=0.04, respectively). There was no measurable effect of rTMS in any other neuropsychological test.
Our pilot study results showed that one session of the high frequency rTMS applied over the left DLPFC was safe in patients with cerebrovascular disease and mild executive deficits, and may induce measurable positive effects on executive functioning.</description><identifier>ISSN: 0022-510X</identifier><identifier>DOI: 10.1016/j.jns.2004.11.021</identifier><identifier>PMID: 15760635</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Aged ; Cerebrovascular ; Cerebrovascular Disorders - psychology ; Cerebrovascular Disorders - therapy ; Cognition ; Cognition - physiology ; Cross-Over Studies ; Double-Blind Method ; Electromagnetic Fields - adverse effects ; Female ; Humans ; Male ; Memory - physiology ; Motor Cortex - physiology ; Neuropsychological Tests ; Pilot Projects ; Prefrontal Cortex - physiology ; Psychiatric Status Rating Scales ; Psychomotor Performance - physiology ; Repetitive transcranial magnetic stimulation ; Wechsler Scales</subject><ispartof>Journal of the neurological sciences, 2005-03, Vol.229, p.157-161</ispartof><rights>2004 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-dcabea6cf904af5d2ed744eebb29eac8691c854635b034d188960c5aeaf19d0c3</citedby><cites>FETCH-LOGICAL-c351t-dcabea6cf904af5d2ed744eebb29eac8691c854635b034d188960c5aeaf19d0c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jns.2004.11.021$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15760635$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rektorova, I.</creatorcontrib><creatorcontrib>Megova, S.</creatorcontrib><creatorcontrib>Bares, M.</creatorcontrib><creatorcontrib>Rektor, I.</creatorcontrib><title>Cognitive functioning after repetitive transcranial magnetic stimulation in patients with cerebrovascular disease without dementia: a pilot study of seven patients</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>Examine whether one session of high frequency repetitive transcranial magnetic stimulation (rTMS) applied over the left dorsolateral prefrontal cortex (DLPFC) would induce any measurable cognitive changes in patients with cerebrovascular disease and mild cognitive deficits.
Seven patients with cerebrovascular disease and mild executive dysfunction entered the randomised, controlled, blinded study with a crossover design. rTMS was applied either over the left DLPFC (an active stimulation site) or over the left motor cortex (MC; a control stimulation site) in one session. Each patient participated in both stimulation sessions (days 1 and 4) and the order of stimulation sites (DLPFC or MC) was randomised. A short battery of neuropsychological tests was performed by a blinded psychologist prior to and after each rTMS session. Psychomotor speed, executive function, and memory were evaluated.
The only mild but significant stimulation site-specific effect of rTMS was observed in the Stroop interference results (i.e. improvement) after the stimulation of DLPFC but not MC in comparison with the baseline scores (Wilcoxon,
Z=−2.03,
p=0.04). Patients improved in the digit symbols subtest of the Wechsler adult intelligence scale-revised after both rTMS sessions regardless of the stimulation site (DLPFC or MC;
Z=−2.06,
p=0.04 and
Z=−2.06,
p=0.04, respectively). There was no measurable effect of rTMS in any other neuropsychological test.
Our pilot study results showed that one session of the high frequency rTMS applied over the left DLPFC was safe in patients with cerebrovascular disease and mild executive deficits, and may induce measurable positive effects on executive functioning.</description><subject>Aged</subject><subject>Cerebrovascular</subject><subject>Cerebrovascular Disorders - psychology</subject><subject>Cerebrovascular Disorders - therapy</subject><subject>Cognition</subject><subject>Cognition - physiology</subject><subject>Cross-Over Studies</subject><subject>Double-Blind Method</subject><subject>Electromagnetic Fields - adverse effects</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Memory - physiology</subject><subject>Motor Cortex - physiology</subject><subject>Neuropsychological Tests</subject><subject>Pilot Projects</subject><subject>Prefrontal Cortex - physiology</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychomotor Performance - physiology</subject><subject>Repetitive transcranial magnetic stimulation</subject><subject>Wechsler Scales</subject><issn>0022-510X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kb1u2zAUhTk0aH6aB8hScMpm5VIWaauZAiNtCgTo0gLdiCvyyqUhkQpJucjz9EVL1waydSEJnO8c4PAwdiOgEiDU3a7a-VTVAE0lRAW1eMcuAOp6IQX8PGeXKe0AQK3X7Xt2LuRKgVrKC_ZnE7beZbcn3s_eZBe881uOfabII02Uj2KO6JMph8OBj7j1RTA8ZTfOAx5c3Hk-lRf5nPhvl39xQ5G6GPaYTGEity4RJvonhjlzS2OBHX7iyCc3hFziZvvKQ88T7ekt7gM763FIdH26r9iPz4_fN0-L529fvm4enhdmKUVeWIMdoTJ9Cw320tZkV01D1HV1S2jWqhVmLZtSu4NlY0X5CgVGImEvWgtmecVuj7lTDC8zpaxHlwwNA3oKc9JqJUG1ShZQHEETQ0qRej1FN2J81QL0YQ2902UNfVhDC6HLGsXz8RQ-dyPZN8dpigLcHwEqFfeOok6m1DdkXSSTtQ3uP_F_AXtPo6I</recordid><startdate>20050315</startdate><enddate>20050315</enddate><creator>Rektorova, I.</creator><creator>Megova, S.</creator><creator>Bares, M.</creator><creator>Rektor, I.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050315</creationdate><title>Cognitive functioning after repetitive transcranial magnetic stimulation in patients with cerebrovascular disease without dementia: a pilot study of seven patients</title><author>Rektorova, I. ; Megova, S. ; Bares, M. ; Rektor, I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-dcabea6cf904af5d2ed744eebb29eac8691c854635b034d188960c5aeaf19d0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Cerebrovascular</topic><topic>Cerebrovascular Disorders - psychology</topic><topic>Cerebrovascular Disorders - therapy</topic><topic>Cognition</topic><topic>Cognition - physiology</topic><topic>Cross-Over Studies</topic><topic>Double-Blind Method</topic><topic>Electromagnetic Fields - adverse effects</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Memory - physiology</topic><topic>Motor Cortex - physiology</topic><topic>Neuropsychological Tests</topic><topic>Pilot Projects</topic><topic>Prefrontal Cortex - physiology</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychomotor Performance - physiology</topic><topic>Repetitive transcranial magnetic stimulation</topic><topic>Wechsler Scales</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rektorova, I.</creatorcontrib><creatorcontrib>Megova, S.</creatorcontrib><creatorcontrib>Bares, M.</creatorcontrib><creatorcontrib>Rektor, I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rektorova, I.</au><au>Megova, S.</au><au>Bares, M.</au><au>Rektor, I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cognitive functioning after repetitive transcranial magnetic stimulation in patients with cerebrovascular disease without dementia: a pilot study of seven patients</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>2005-03-15</date><risdate>2005</risdate><volume>229</volume><spage>157</spage><epage>161</epage><pages>157-161</pages><issn>0022-510X</issn><abstract>Examine whether one session of high frequency repetitive transcranial magnetic stimulation (rTMS) applied over the left dorsolateral prefrontal cortex (DLPFC) would induce any measurable cognitive changes in patients with cerebrovascular disease and mild cognitive deficits.
Seven patients with cerebrovascular disease and mild executive dysfunction entered the randomised, controlled, blinded study with a crossover design. rTMS was applied either over the left DLPFC (an active stimulation site) or over the left motor cortex (MC; a control stimulation site) in one session. Each patient participated in both stimulation sessions (days 1 and 4) and the order of stimulation sites (DLPFC or MC) was randomised. A short battery of neuropsychological tests was performed by a blinded psychologist prior to and after each rTMS session. Psychomotor speed, executive function, and memory were evaluated.
The only mild but significant stimulation site-specific effect of rTMS was observed in the Stroop interference results (i.e. improvement) after the stimulation of DLPFC but not MC in comparison with the baseline scores (Wilcoxon,
Z=−2.03,
p=0.04). Patients improved in the digit symbols subtest of the Wechsler adult intelligence scale-revised after both rTMS sessions regardless of the stimulation site (DLPFC or MC;
Z=−2.06,
p=0.04 and
Z=−2.06,
p=0.04, respectively). There was no measurable effect of rTMS in any other neuropsychological test.
Our pilot study results showed that one session of the high frequency rTMS applied over the left DLPFC was safe in patients with cerebrovascular disease and mild executive deficits, and may induce measurable positive effects on executive functioning.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>15760635</pmid><doi>10.1016/j.jns.2004.11.021</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-510X |
| ispartof | Journal of the neurological sciences, 2005-03, Vol.229, p.157-161 |
| issn | 0022-510X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67506965 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Aged Cerebrovascular Cerebrovascular Disorders - psychology Cerebrovascular Disorders - therapy Cognition Cognition - physiology Cross-Over Studies Double-Blind Method Electromagnetic Fields - adverse effects Female Humans Male Memory - physiology Motor Cortex - physiology Neuropsychological Tests Pilot Projects Prefrontal Cortex - physiology Psychiatric Status Rating Scales Psychomotor Performance - physiology Repetitive transcranial magnetic stimulation Wechsler Scales |
| title | Cognitive functioning after repetitive transcranial magnetic stimulation in patients with cerebrovascular disease without dementia: a pilot study of seven patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T16%3A29%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cognitive%20functioning%20after%20repetitive%20transcranial%20magnetic%20stimulation%20in%20patients%20with%20cerebrovascular%20disease%20without%20dementia:%20a%20pilot%20study%20of%20seven%20patients&rft.jtitle=Journal%20of%20the%20neurological%20sciences&rft.au=Rektorova,%20I.&rft.date=2005-03-15&rft.volume=229&rft.spage=157&rft.epage=161&rft.pages=157-161&rft.issn=0022-510X&rft_id=info:doi/10.1016/j.jns.2004.11.021&rft_dat=%3Cproquest_cross%3E67506965%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67506965&rft_id=info:pmid/15760635&rft_els_id=S0022510X04004447&rfr_iscdi=true |