Predictive models, based on classification algorithms, for compounds potentially active as mitochondrial ATP-sensitive potassium channel openers

A series of 4-spiro-substituted benzopyran derivatives are exploited in order to develop classification models capable of discriminating between cardioprotective and non-cardioprotective agents. Heart mitochondrial ATP-sensitive potassium channel (mito-K ATP channels) are deeply implicated in the se...

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Veröffentlicht in:Bioorganic & medicinal chemistry 2009-08, Vol.17 (15), p.5565-5571
Hauptverfasser: Coi, Alessio, Bianucci, Anna Maria, Calderone, Vincenzo, Testai, Lara, Digiacomo, Maria, Rapposelli, Simona, Balsamo, Aldo
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Sprache:eng
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