Heat-stable enterotoxin of Escherichia coli stimulates a non-CFTR-mediated duodenal bicarbonate secretory pathway

The cystic fibrosis (CF) transmembrane conductance regulator (CFTR) is an important pathway for duodenal mucosal bicarbonate secretion. Duodenal biopsies from CF patients secrete bicarbonate in response to heat-stable enterotoxin from Escherichia coli (STa) but not cAMP. To explore the mechanism of...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2005-04, Vol.288 (4), p.G654-G663
Hauptverfasser:	Sellers, Zachary M, Childs, Debbie, Chow, Jimmy Y C, Smith, Anders J, Hogan, Daniel L, Isenberg, Jon I, Dong, Hui, Barrett, Kim E, Pratha, Vijaya S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Toxins - pharmacology Benzoquinones Bicarbonates - metabolism Cell Membrane - metabolism Chloride-Bicarbonate Antiporters - metabolism Colforsin - pharmacology Cyclic GMP - analogs & derivatives Cyclic GMP - pharmacology Cystic Fibrosis - metabolism Duodenum - metabolism Enterotoxins - pharmacology Enzyme Inhibitors - pharmacology Escherichia coli Proteins Genistein - pharmacology In Vitro Techniques Lactams, Macrocyclic Mice Natriuretic Peptides Peptides - pharmacology Protein-Tyrosine Kinases - antagonists & inhibitors Quinones - pharmacology Rifabutin - analogs & derivatives
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!