Impact of Smoking on Fracture Healing and Risk of Complications in Limb-Threatening Open Tibia Fractures
OBJECTIVES:Current data show smoking is associated with a number of complications of the fracture healing process. A concern, however, is the potential confounding effect of covariates associated with smoking. The present study is the first to prospectively examine time to union, as well as major co...
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| Veröffentlicht in: | Journal of orthopaedic trauma 2005-03, Vol.19 (3), p.151-157 |
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| container_title | Journal of orthopaedic trauma |
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| creator | Castillo, Renan C Bosse, Michael J MacKenzie, Ellen J Patterson, Brendan M |
| description | OBJECTIVES:Current data show smoking is associated with a number of complications of the fracture healing process. A concern, however, is the potential confounding effect of covariates associated with smoking. The present study is the first to prospectively examine time to union, as well as major complications of the fracture healing process, while adjusting for potential confounders.
SETTING:Eight Level I trauma centers.
PATIENTS:Patients with unilateral open tibia fractures were divided into 3 baseline smoking categoriesnever smoked (n = 81), previous smoker (n = 82), and current smoker (n = 105).
OUTCOME MEASURE:Time to fracture healing, diagnosis of infection, and osteomyelitis.
METHODS:Survival and logistic analyses were used to study differences in time to fracture healing and the likelihood of developing complications, respectively. Multivariate models were used to adjust for injury severity, treatment variations, and patient characteristics
RESULTS:After adjusting for covariates, current and previous smokers were 37% (P = 0.01) and 32% (P = 0.04) less likely to achieve union than nonsmokers, respectively. Current smokers were more than twice as likely to develop an infection (P = 0.05) and 3.7 times as likely to develop osteomyelitis (P = 0.01). Previous smokers were 2.8 times as likely to develop osteomyelitis (P = 0.07), but were at no greater risk for other types of infection.
CONCLUSION:Smoking places the patient at risk for increased time to union and complications. Previous smoking history also appears to increase the risk of osteomyelitis and increased time to union. The results highlight the need for orthopaedic surgeons to encourage their patients to enter a smoking cessation programs. |
| doi_str_mv | 10.1097/00005131-200503000-00001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67502726</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67502726</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3881-9e644c073de18d93d9aa325f7612f796f32a05aa98810a7e9e60096e1508f1753</originalsourceid><addsrcrecordid>eNp10ctu1DAUBmALUdGh8ArIG9gFfBnb8RKN6EUaqRId1taZ5IQxk9jBTlTx9jidoV3hzZF_fbal34RQzj5zZs0XVpbikleiTCbLrloi_oqsuFpiYflrsmK1ZZWS0l6Stzn_KqJmQrwhl1wZVWttVuRwN4zQTDR29GGIRx9-0hjodSrZnJDeIvRLBqGl330-Lm4Th7H3DUw-hkx9oFs_7KvdISFMGBZ9P2KgO7_38HxTfkcuOugzvj_PK_Lj-ttuc1tt72_uNl-3VSPrmlcW9XrdMCNb5HVrZWsBpFCd0Vx0xupOCmAKwBbMwGDxjFmNXLG640bJK_LpdO-Y4u8Z8-QGnxvsewgY5-y0UUwYoQusT7BJMeeEnRuTHyD9cZy5pWX3r2X33PJTxMvRD-c35v2A7cvBc60FfDwDyA30XYLQ-PzitFbGGFvc-uQeYz9hysd-fsTkDqX16eD-98vyL19WkrU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67502726</pqid></control><display><type>article</type><title>Impact of Smoking on Fracture Healing and Risk of Complications in Limb-Threatening Open Tibia Fractures</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Castillo, Renan C ; Bosse, Michael J ; MacKenzie, Ellen J ; Patterson, Brendan M</creator><creatorcontrib>Castillo, Renan C ; Bosse, Michael J ; MacKenzie, Ellen J ; Patterson, Brendan M ; LEAP Study Group</creatorcontrib><description>OBJECTIVES:Current data show smoking is associated with a number of complications of the fracture healing process. A concern, however, is the potential confounding effect of covariates associated with smoking. The present study is the first to prospectively examine time to union, as well as major complications of the fracture healing process, while adjusting for potential confounders.
SETTING:Eight Level I trauma centers.
PATIENTS:Patients with unilateral open tibia fractures were divided into 3 baseline smoking categoriesnever smoked (n = 81), previous smoker (n = 82), and current smoker (n = 105).
OUTCOME MEASURE:Time to fracture healing, diagnosis of infection, and osteomyelitis.
METHODS:Survival and logistic analyses were used to study differences in time to fracture healing and the likelihood of developing complications, respectively. Multivariate models were used to adjust for injury severity, treatment variations, and patient characteristics
RESULTS:After adjusting for covariates, current and previous smokers were 37% (P = 0.01) and 32% (P = 0.04) less likely to achieve union than nonsmokers, respectively. Current smokers were more than twice as likely to develop an infection (P = 0.05) and 3.7 times as likely to develop osteomyelitis (P = 0.01). Previous smokers were 2.8 times as likely to develop osteomyelitis (P = 0.07), but were at no greater risk for other types of infection.
CONCLUSION:Smoking places the patient at risk for increased time to union and complications. Previous smoking history also appears to increase the risk of osteomyelitis and increased time to union. The results highlight the need for orthopaedic surgeons to encourage their patients to enter a smoking cessation programs.</description><identifier>ISSN: 0890-5339</identifier><identifier>EISSN: 1531-2291</identifier><identifier>DOI: 10.1097/00005131-200503000-00001</identifier><identifier>PMID: 15758667</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Bacterial arthritis and osteitis ; Bacterial diseases ; Biological and medical sciences ; Fracture Healing ; Fractures, Open - classification ; Fractures, Open - complications ; Fractures, Open - therapy ; Human bacterial diseases ; Humans ; Infectious diseases ; Injuries of the limb. Injuries of the spine ; Injury Severity Score ; Logistic Models ; Medical sciences ; Middle Aged ; Osteomyelitis - etiology ; Smoking - adverse effects ; Tibial Fractures - classification ; Tibial Fractures - complications ; Tibial Fractures - therapy ; Time Factors ; Tobacco, tobacco smoking ; Toxicology ; Trauma Centers ; Traumas. Diseases due to physical agents</subject><ispartof>Journal of orthopaedic trauma, 2005-03, Vol.19 (3), p.151-157</ispartof><rights>2005 Lippincott Williams & Wilkins, Inc.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3881-9e644c073de18d93d9aa325f7612f796f32a05aa98810a7e9e60096e1508f1753</citedby><cites>FETCH-LOGICAL-c3881-9e644c073de18d93d9aa325f7612f796f32a05aa98810a7e9e60096e1508f1753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16657779$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15758667$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Castillo, Renan C</creatorcontrib><creatorcontrib>Bosse, Michael J</creatorcontrib><creatorcontrib>MacKenzie, Ellen J</creatorcontrib><creatorcontrib>Patterson, Brendan M</creatorcontrib><creatorcontrib>LEAP Study Group</creatorcontrib><title>Impact of Smoking on Fracture Healing and Risk of Complications in Limb-Threatening Open Tibia Fractures</title><title>Journal of orthopaedic trauma</title><addtitle>J Orthop Trauma</addtitle><description>OBJECTIVES:Current data show smoking is associated with a number of complications of the fracture healing process. A concern, however, is the potential confounding effect of covariates associated with smoking. The present study is the first to prospectively examine time to union, as well as major complications of the fracture healing process, while adjusting for potential confounders.
SETTING:Eight Level I trauma centers.
PATIENTS:Patients with unilateral open tibia fractures were divided into 3 baseline smoking categoriesnever smoked (n = 81), previous smoker (n = 82), and current smoker (n = 105).
OUTCOME MEASURE:Time to fracture healing, diagnosis of infection, and osteomyelitis.
METHODS:Survival and logistic analyses were used to study differences in time to fracture healing and the likelihood of developing complications, respectively. Multivariate models were used to adjust for injury severity, treatment variations, and patient characteristics
RESULTS:After adjusting for covariates, current and previous smokers were 37% (P = 0.01) and 32% (P = 0.04) less likely to achieve union than nonsmokers, respectively. Current smokers were more than twice as likely to develop an infection (P = 0.05) and 3.7 times as likely to develop osteomyelitis (P = 0.01). Previous smokers were 2.8 times as likely to develop osteomyelitis (P = 0.07), but were at no greater risk for other types of infection.
CONCLUSION:Smoking places the patient at risk for increased time to union and complications. Previous smoking history also appears to increase the risk of osteomyelitis and increased time to union. The results highlight the need for orthopaedic surgeons to encourage their patients to enter a smoking cessation programs.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Bacterial arthritis and osteitis</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Fracture Healing</subject><subject>Fractures, Open - classification</subject><subject>Fractures, Open - complications</subject><subject>Fractures, Open - therapy</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Injuries of the limb. Injuries of the spine</subject><subject>Injury Severity Score</subject><subject>Logistic Models</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Osteomyelitis - etiology</subject><subject>Smoking - adverse effects</subject><subject>Tibial Fractures - classification</subject><subject>Tibial Fractures - complications</subject><subject>Tibial Fractures - therapy</subject><subject>Time Factors</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><subject>Trauma Centers</subject><subject>Traumas. Diseases due to physical agents</subject><issn>0890-5339</issn><issn>1531-2291</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10ctu1DAUBmALUdGh8ArIG9gFfBnb8RKN6EUaqRId1taZ5IQxk9jBTlTx9jidoV3hzZF_fbal34RQzj5zZs0XVpbikleiTCbLrloi_oqsuFpiYflrsmK1ZZWS0l6Stzn_KqJmQrwhl1wZVWttVuRwN4zQTDR29GGIRx9-0hjodSrZnJDeIvRLBqGl330-Lm4Th7H3DUw-hkx9oFs_7KvdISFMGBZ9P2KgO7_38HxTfkcuOugzvj_PK_Lj-ttuc1tt72_uNl-3VSPrmlcW9XrdMCNb5HVrZWsBpFCd0Vx0xupOCmAKwBbMwGDxjFmNXLG640bJK_LpdO-Y4u8Z8-QGnxvsewgY5-y0UUwYoQusT7BJMeeEnRuTHyD9cZy5pWX3r2X33PJTxMvRD-c35v2A7cvBc60FfDwDyA30XYLQ-PzitFbGGFvc-uQeYz9hysd-fsTkDqX16eD-98vyL19WkrU</recordid><startdate>200503</startdate><enddate>200503</enddate><creator>Castillo, Renan C</creator><creator>Bosse, Michael J</creator><creator>MacKenzie, Ellen J</creator><creator>Patterson, Brendan M</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200503</creationdate><title>Impact of Smoking on Fracture Healing and Risk of Complications in Limb-Threatening Open Tibia Fractures</title><author>Castillo, Renan C ; Bosse, Michael J ; MacKenzie, Ellen J ; Patterson, Brendan M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3881-9e644c073de18d93d9aa325f7612f796f32a05aa98810a7e9e60096e1508f1753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Bacterial arthritis and osteitis</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Fracture Healing</topic><topic>Fractures, Open - classification</topic><topic>Fractures, Open - complications</topic><topic>Fractures, Open - therapy</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Injuries of the limb. Injuries of the spine</topic><topic>Injury Severity Score</topic><topic>Logistic Models</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Osteomyelitis - etiology</topic><topic>Smoking - adverse effects</topic><topic>Tibial Fractures - classification</topic><topic>Tibial Fractures - complications</topic><topic>Tibial Fractures - therapy</topic><topic>Time Factors</topic><topic>Tobacco, tobacco smoking</topic><topic>Toxicology</topic><topic>Trauma Centers</topic><topic>Traumas. Diseases due to physical agents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Castillo, Renan C</creatorcontrib><creatorcontrib>Bosse, Michael J</creatorcontrib><creatorcontrib>MacKenzie, Ellen J</creatorcontrib><creatorcontrib>Patterson, Brendan M</creatorcontrib><creatorcontrib>LEAP Study Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of orthopaedic trauma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Castillo, Renan C</au><au>Bosse, Michael J</au><au>MacKenzie, Ellen J</au><au>Patterson, Brendan M</au><aucorp>LEAP Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Smoking on Fracture Healing and Risk of Complications in Limb-Threatening Open Tibia Fractures</atitle><jtitle>Journal of orthopaedic trauma</jtitle><addtitle>J Orthop Trauma</addtitle><date>2005-03</date><risdate>2005</risdate><volume>19</volume><issue>3</issue><spage>151</spage><epage>157</epage><pages>151-157</pages><issn>0890-5339</issn><eissn>1531-2291</eissn><abstract>OBJECTIVES:Current data show smoking is associated with a number of complications of the fracture healing process. A concern, however, is the potential confounding effect of covariates associated with smoking. The present study is the first to prospectively examine time to union, as well as major complications of the fracture healing process, while adjusting for potential confounders.
SETTING:Eight Level I trauma centers.
PATIENTS:Patients with unilateral open tibia fractures were divided into 3 baseline smoking categoriesnever smoked (n = 81), previous smoker (n = 82), and current smoker (n = 105).
OUTCOME MEASURE:Time to fracture healing, diagnosis of infection, and osteomyelitis.
METHODS:Survival and logistic analyses were used to study differences in time to fracture healing and the likelihood of developing complications, respectively. Multivariate models were used to adjust for injury severity, treatment variations, and patient characteristics
RESULTS:After adjusting for covariates, current and previous smokers were 37% (P = 0.01) and 32% (P = 0.04) less likely to achieve union than nonsmokers, respectively. Current smokers were more than twice as likely to develop an infection (P = 0.05) and 3.7 times as likely to develop osteomyelitis (P = 0.01). Previous smokers were 2.8 times as likely to develop osteomyelitis (P = 0.07), but were at no greater risk for other types of infection.
CONCLUSION:Smoking places the patient at risk for increased time to union and complications. Previous smoking history also appears to increase the risk of osteomyelitis and increased time to union. The results highlight the need for orthopaedic surgeons to encourage their patients to enter a smoking cessation programs.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>15758667</pmid><doi>10.1097/00005131-200503000-00001</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adult Aged Bacterial arthritis and osteitis Bacterial diseases Biological and medical sciences Fracture Healing Fractures, Open - classification Fractures, Open - complications Fractures, Open - therapy Human bacterial diseases Humans Infectious diseases Injuries of the limb. Injuries of the spine Injury Severity Score Logistic Models Medical sciences Middle Aged Osteomyelitis - etiology Smoking - adverse effects Tibial Fractures - classification Tibial Fractures - complications Tibial Fractures - therapy Time Factors Tobacco, tobacco smoking Toxicology Trauma Centers Traumas. Diseases due to physical agents |
| title | Impact of Smoking on Fracture Healing and Risk of Complications in Limb-Threatening Open Tibia Fractures |
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