Association of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma2 with decreased basic metabolic rate in women with polycystic ovary syndrome
The peroxisome proliferator-activated receptor (PPAR)gamma is a transcription factor involved in glucose homeostasis and energy metabolism. A missense mutation at codon 12 in the PPARgamma2 has been associated with increased body mass index (BMI) and attenuated insulin resistance (IR) in polycystic...
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| Veröffentlicht in: | European journal of endocrinology 2009-08, Vol.161 (2), p.317-322 |
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| container_title | European journal of endocrinology |
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| creator | Koika, Vasiliki Marioli, Dimitra J Saltamavros, Alexandros D Vervita, Vasiliki Koufogiannis, Kleanthis D Adonakis, George Decavalas, George Georgopoulos, Neoklis A |
| description | The peroxisome proliferator-activated receptor (PPAR)gamma is a transcription factor involved in glucose homeostasis and energy metabolism. A missense mutation at codon 12 in the PPARgamma2 has been associated with increased body mass index (BMI) and attenuated insulin resistance (IR) in polycystic ovary syndrome (PCOS). We have recently shown a decreased basic metabolic rate (BMR) in PCOS. The aim of the present study is to determine the prevalence of the Pro12Ala polymorphism of the PPARgamma2 gene and its associations with indices of IR and BMR in lean and slightly overweight PCOS women.
Case-control association study involving 156 PCOS women with biochemical hyperandrogenism, chronic anovulation and polycystic ovarian morphology in ultrasound and 56 unrelated healthy controls.
Hormonal determinations were performed by electrochemiluminescence quantitation or RIA. BMR was measured by indirect calorimetry. All subjects were genotyped by a PCR-restriction fragment length polymorphism assay.
Genotype frequencies of the Pro12Ala polymorphism in PPARgamma2 did not differ among PCOS women and control subjects. The presence of Pro12Ala polymorphism of PPARgamma2 was associated with lower BMR (P=0.04). This finding was valid in our subgroup of lean PCOS (BMI |
| doi_str_mv | 10.1530/EJE-08-1014 |
| format | Article |
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Case-control association study involving 156 PCOS women with biochemical hyperandrogenism, chronic anovulation and polycystic ovarian morphology in ultrasound and 56 unrelated healthy controls.
Hormonal determinations were performed by electrochemiluminescence quantitation or RIA. BMR was measured by indirect calorimetry. All subjects were genotyped by a PCR-restriction fragment length polymorphism assay.
Genotype frequencies of the Pro12Ala polymorphism in PPARgamma2 did not differ among PCOS women and control subjects. The presence of Pro12Ala polymorphism of PPARgamma2 was associated with lower BMR (P=0.04). This finding was valid in our subgroup of lean PCOS (BMI<25 kg/m(2)), in which the Ala variant was also associated with higher total testosterone values.
The Pro12Ala polymorphism in the PPARgamma2 gene is associated with decreased BMR in women with PCOS and biochemical hyperandrogenemia. These young women are therefore at risk to increase their body weight and should restrict their energy intake by diet and enhance their energy expenditure by exercise.</description><identifier>EISSN: 1479-683X</identifier><identifier>DOI: 10.1530/EJE-08-1014</identifier><identifier>PMID: 19465486</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Basal Metabolism - genetics ; Blood Glucose - metabolism ; Calorimetry, Indirect ; Case-Control Studies ; DNA - chemistry ; DNA - genetics ; Female ; Genetic Variation ; Genotype ; Humans ; Insulin - blood ; Insulin Resistance - physiology ; Mutation, Missense ; Polycystic Ovary Syndrome - blood ; Polycystic Ovary Syndrome - genetics ; Polycystic Ovary Syndrome - metabolism ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide ; PPAR gamma - genetics ; Statistics, Nonparametric ; Testosterone - blood ; Young Adult</subject><ispartof>European journal of endocrinology, 2009-08, Vol.161 (2), p.317-322</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19465486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koika, Vasiliki</creatorcontrib><creatorcontrib>Marioli, Dimitra J</creatorcontrib><creatorcontrib>Saltamavros, Alexandros D</creatorcontrib><creatorcontrib>Vervita, Vasiliki</creatorcontrib><creatorcontrib>Koufogiannis, Kleanthis D</creatorcontrib><creatorcontrib>Adonakis, George</creatorcontrib><creatorcontrib>Decavalas, George</creatorcontrib><creatorcontrib>Georgopoulos, Neoklis A</creatorcontrib><title>Association of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma2 with decreased basic metabolic rate in women with polycystic ovary syndrome</title><title>European journal of endocrinology</title><addtitle>Eur J Endocrinol</addtitle><description>The peroxisome proliferator-activated receptor (PPAR)gamma is a transcription factor involved in glucose homeostasis and energy metabolism. A missense mutation at codon 12 in the PPARgamma2 has been associated with increased body mass index (BMI) and attenuated insulin resistance (IR) in polycystic ovary syndrome (PCOS). We have recently shown a decreased basic metabolic rate (BMR) in PCOS. The aim of the present study is to determine the prevalence of the Pro12Ala polymorphism of the PPARgamma2 gene and its associations with indices of IR and BMR in lean and slightly overweight PCOS women.
Case-control association study involving 156 PCOS women with biochemical hyperandrogenism, chronic anovulation and polycystic ovarian morphology in ultrasound and 56 unrelated healthy controls.
Hormonal determinations were performed by electrochemiluminescence quantitation or RIA. BMR was measured by indirect calorimetry. All subjects were genotyped by a PCR-restriction fragment length polymorphism assay.
Genotype frequencies of the Pro12Ala polymorphism in PPARgamma2 did not differ among PCOS women and control subjects. The presence of Pro12Ala polymorphism of PPARgamma2 was associated with lower BMR (P=0.04). This finding was valid in our subgroup of lean PCOS (BMI<25 kg/m(2)), in which the Ala variant was also associated with higher total testosterone values.
The Pro12Ala polymorphism in the PPARgamma2 gene is associated with decreased BMR in women with PCOS and biochemical hyperandrogenemia. These young women are therefore at risk to increase their body weight and should restrict their energy intake by diet and enhance their energy expenditure by exercise.</description><subject>Adult</subject><subject>Basal Metabolism - genetics</subject><subject>Blood Glucose - metabolism</subject><subject>Calorimetry, Indirect</subject><subject>Case-Control Studies</subject><subject>DNA - chemistry</subject><subject>DNA - genetics</subject><subject>Female</subject><subject>Genetic Variation</subject><subject>Genotype</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Insulin Resistance - physiology</subject><subject>Mutation, Missense</subject><subject>Polycystic Ovary Syndrome - blood</subject><subject>Polycystic Ovary Syndrome - genetics</subject><subject>Polycystic Ovary Syndrome - metabolism</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Polymorphism, Single Nucleotide</subject><subject>PPAR gamma - genetics</subject><subject>Statistics, Nonparametric</subject><subject>Testosterone - blood</subject><subject>Young Adult</subject><issn>1479-683X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UEtPAjEQbkyMIHrybnryttrS7utICL5CogcO3si0O0jNdru2BeQn-S8tAS_zJfM95kHIDWf3PBfsYfY6y1iVccblGRlyWdZZUYmPAbkM4YsxXkjBLsiA17LIZVUMye8kBKcNROM66lY0rpG-e8fHkxZo79q9db5fm2Cp6WiP3v2Y4CzS3rvWrNBDdD4DHc0WIjbUo8Y-tegnWAtjujNxTRvUHiEkWkEwmlqMoJJd02THQ_AuRXZH8WGm3oeYWLcFv6dh3zU-8VfkfAVtwOsTjsjicbaYPmfzt6eX6WSe9bkssqYRlVK1Fqi0zFkpFIyrSmAFDPXhAQkaqMcAZSp5kmJZ1BVyJUEJKcSI3B1j04XfGwxxaU3Q2LbQoduEZVHKui7EQXh7Em6UxWbZe2PTvsv_34o_3g9-ZA</recordid><startdate>200908</startdate><enddate>200908</enddate><creator>Koika, Vasiliki</creator><creator>Marioli, Dimitra J</creator><creator>Saltamavros, Alexandros D</creator><creator>Vervita, Vasiliki</creator><creator>Koufogiannis, Kleanthis D</creator><creator>Adonakis, George</creator><creator>Decavalas, George</creator><creator>Georgopoulos, Neoklis A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200908</creationdate><title>Association of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma2 with decreased basic metabolic rate in women with polycystic ovary syndrome</title><author>Koika, Vasiliki ; Marioli, Dimitra J ; Saltamavros, Alexandros D ; Vervita, Vasiliki ; Koufogiannis, Kleanthis D ; Adonakis, George ; Decavalas, George ; Georgopoulos, Neoklis A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p546-dd38bb9c3ebc45073ba2883e8a0ec00160ecda92aa792a5bb9e7698e1b4ab3433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Basal Metabolism - genetics</topic><topic>Blood Glucose - metabolism</topic><topic>Calorimetry, Indirect</topic><topic>Case-Control Studies</topic><topic>DNA - chemistry</topic><topic>DNA - genetics</topic><topic>Female</topic><topic>Genetic Variation</topic><topic>Genotype</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Insulin Resistance - physiology</topic><topic>Mutation, Missense</topic><topic>Polycystic Ovary Syndrome - blood</topic><topic>Polycystic Ovary Syndrome - genetics</topic><topic>Polycystic Ovary Syndrome - metabolism</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Polymorphism, Single Nucleotide</topic><topic>PPAR gamma - genetics</topic><topic>Statistics, Nonparametric</topic><topic>Testosterone - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koika, Vasiliki</creatorcontrib><creatorcontrib>Marioli, Dimitra J</creatorcontrib><creatorcontrib>Saltamavros, Alexandros D</creatorcontrib><creatorcontrib>Vervita, Vasiliki</creatorcontrib><creatorcontrib>Koufogiannis, Kleanthis D</creatorcontrib><creatorcontrib>Adonakis, George</creatorcontrib><creatorcontrib>Decavalas, George</creatorcontrib><creatorcontrib>Georgopoulos, Neoklis A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koika, Vasiliki</au><au>Marioli, Dimitra J</au><au>Saltamavros, Alexandros D</au><au>Vervita, Vasiliki</au><au>Koufogiannis, Kleanthis D</au><au>Adonakis, George</au><au>Decavalas, George</au><au>Georgopoulos, Neoklis A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma2 with decreased basic metabolic rate in women with polycystic ovary syndrome</atitle><jtitle>European journal of endocrinology</jtitle><addtitle>Eur J Endocrinol</addtitle><date>2009-08</date><risdate>2009</risdate><volume>161</volume><issue>2</issue><spage>317</spage><epage>322</epage><pages>317-322</pages><eissn>1479-683X</eissn><abstract>The peroxisome proliferator-activated receptor (PPAR)gamma is a transcription factor involved in glucose homeostasis and energy metabolism. A missense mutation at codon 12 in the PPARgamma2 has been associated with increased body mass index (BMI) and attenuated insulin resistance (IR) in polycystic ovary syndrome (PCOS). We have recently shown a decreased basic metabolic rate (BMR) in PCOS. The aim of the present study is to determine the prevalence of the Pro12Ala polymorphism of the PPARgamma2 gene and its associations with indices of IR and BMR in lean and slightly overweight PCOS women.
Case-control association study involving 156 PCOS women with biochemical hyperandrogenism, chronic anovulation and polycystic ovarian morphology in ultrasound and 56 unrelated healthy controls.
Hormonal determinations were performed by electrochemiluminescence quantitation or RIA. BMR was measured by indirect calorimetry. All subjects were genotyped by a PCR-restriction fragment length polymorphism assay.
Genotype frequencies of the Pro12Ala polymorphism in PPARgamma2 did not differ among PCOS women and control subjects. The presence of Pro12Ala polymorphism of PPARgamma2 was associated with lower BMR (P=0.04). This finding was valid in our subgroup of lean PCOS (BMI<25 kg/m(2)), in which the Ala variant was also associated with higher total testosterone values.
The Pro12Ala polymorphism in the PPARgamma2 gene is associated with decreased BMR in women with PCOS and biochemical hyperandrogenemia. These young women are therefore at risk to increase their body weight and should restrict their energy intake by diet and enhance their energy expenditure by exercise.</abstract><cop>England</cop><pmid>19465486</pmid><doi>10.1530/EJE-08-1014</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adult Basal Metabolism - genetics Blood Glucose - metabolism Calorimetry, Indirect Case-Control Studies DNA - chemistry DNA - genetics Female Genetic Variation Genotype Humans Insulin - blood Insulin Resistance - physiology Mutation, Missense Polycystic Ovary Syndrome - blood Polycystic Ovary Syndrome - genetics Polycystic Ovary Syndrome - metabolism Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide PPAR gamma - genetics Statistics, Nonparametric Testosterone - blood Young Adult |
| title | Association of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma2 with decreased basic metabolic rate in women with polycystic ovary syndrome |
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