Stool Methylation-Specific Polymerase Chain Reaction Assay for the Detection of Colorectal Neoplasia in Korean Patients

PURPOSE:To investigate the feasibility of detecting hypermethylation in stool samples as a noninvasive screening tool for colorectal cancer and precancerous lesions, we evaluated the hypermethylation of three genes in the stool samples of patients with colorectal cancer, patients with colorectal ade...

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Veröffentlicht in:	Diseases of the colon & rectum 2009-08, Vol.52 (8), p.1452-1459
Hauptverfasser:	Baek, Yoo Hum, Chang, Eugene, Kim, Young Jin, Kim, Bo Kyoung, Sohn, Jin Hee, Park, Dong Il
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Colorectal Neoplasms - diagnosis Colorectal Neoplasms - epidemiology Colorectal Neoplasms - genetics Diagnosis, Differential DNA Methylation DNA Repair Enzymes DNA, Neoplasm - genetics Epigenesis, Genetic Feces - chemistry Female Humans Korea - epidemiology Male Middle Aged MutL Protein Homolog 1 Nuclear Proteins - genetics Nuclear Proteins - metabolism O-Methylguanine-DNA Methyltransferase - genetics O-Methylguanine-DNA Methyltransferase - metabolism Polymerase Chain Reaction - methods Prevalence Promoter Regions, Genetic Retrospective Studies Risk Factors Vimentin - genetics Vimentin - metabolism
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