Interleukin-10 but not transforming growth factor-β is essential for generation and suppressor function of regulatory cells induced by intratracheal delivery of alloantigen

We previously reported that intratracheal delivery of alloantigen-induced regulatory cells in mouse heart-transplantation model. Here, we investigated roles of interleukin (IL)-10 and transforming growth factor (TGF)-beta in induction and effector phases of the regulatory cells. CBA mice were pretre...

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Veröffentlicht in:	Transplantation 2005-03, Vol.79 (5), p.568-576
Hauptverfasser:	ARAMAKI, Osamu, INOUE, Fumihiko, TAKAYAMA, Tadatoshi, SHIMAZU, Motohide, KITAJIMA, Masaki, IKEDA, Yoshifumi, OKUMURA, Ko, YAGITA, Hideo, SHIRASUGI, Nozomu, NIIMI, Masanori
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology Biological and medical sciences Fundamental and applied biological sciences. Psychology Fundamental immunology Graft Rejection Interleukin-10 - physiology Isoantigens - administration & dosage Isoantigens - immunology Male Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred DBA Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases T-Lymphocytes, Regulatory - immunology Tissue Donors Tissue, organ and graft immunology Trachea Transforming Growth Factor beta - physiology
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