Cyclic phosphoramidates as prodrugs of 2′- C-methylcytidine

The currently approved treatment for hepatitis C virus infections is a combination of Ribavirin and pegylated Interferon. It leads to a sustained virologic response in approximately only half of the patients treated. For this reason there is an urgent need of new therapeutic agents. 2′- C-Methylcyti...

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Veröffentlicht in:	European journal of medicinal chemistry 2009-09, Vol.44 (9), p.3765-3770
Hauptverfasser:	Meppen, Malte, Pacini, Barbara, Bazzo, Renzo, Koch, Uwe, Leone, Joseph F., Koeplinger, Kenneth A., Rowley, Michael, Altamura, Sergio, Di Marco, Annalise, Fiore, Fabrizio, Giuliano, Claudio, Gonzalez-Paz, Odalys, Laufer, Ralph, Pucci, Vincenzo, Narjes, Frank, Gardelli, Cristina
Format:	Artikel
Sprache:	eng
Schlagworte:	2′- C-Methylcytidine Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agent Antiviral agents Antiviral Agents - administration & dosage Antiviral Agents - chemistry Antiviral Agents - metabolism Antiviral Agents - pharmacology Biological and medical sciences Cricetinae Cyclic phosphoramidate Cytidine - administration & dosage Cytidine - analogs & derivatives Cytidine - chemistry Cytidine - metabolism Cytidine - pharmacology Drug Stability Hepacivirus - drug effects Hepatitis C Hepatitis C - drug therapy Hepatocytes - virology Humans Medical sciences Monophosphate prodrug Pharmacology. Drug treatments Prodrugs - administration & dosage Prodrugs - chemistry Prodrugs - metabolism Prodrugs - pharmacology Structure-Activity Relationship
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