Genetic polymorphisms of GnRH and gonadotrophic hormone receptors affect the phenotype of polycystic ovary syndrome

BACKGROUND Polycystic ovary syndrome (PCOS) is a complex genetic disorder. Multiple functional polymorphisms have been identified in genes that regulate the hypothalamic–pituitary–gonadal (HPG) axis that regulates ovarian function. The present study aims to examine the influence of genetic variants...

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Veröffentlicht in:	Human reproduction (Oxford) 2009-08, Vol.24 (8), p.2014-2022
Hauptverfasser:	Valkenburg, O., Uitterlinden, A.G., Piersma, D., Hofman, A., Themmen, A.P.N., de Jong, F.H., Fauser, B.C.J.M., Laven, J.S.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Female Follicle Stimulating Hormone - blood FSH receptor Genetic Predisposition to Disease GnRH Gonadotropin-Releasing Hormone - genetics Gynecology. Andrology. Obstetrics Humans Hyperandrogenism - genetics LH receptor Luteinizing Hormone - blood Medical sciences Middle Aged Phenotype polycystic ovary syndrome Polycystic Ovary Syndrome - genetics polymorphism Polymorphism, Single Nucleotide Prospective Studies Receptors, FSH - genetics Receptors, LH - genetics Testosterone - blood
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