Complement: central to innate immunity and bridging to adaptive responses
The complement system, a pillar of innate immunity, has belatedly become recognised as a key modulator of adaptive immunity, acting to direct, modulate and modify the responses of lymphocytes to stimuli. These effects are mediated by interactions between complement components or activation-derived f...
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| Veröffentlicht in: | Immunology letters 2005-03, Vol.97 (2), p.171-179 |
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| container_end_page | 179 |
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| container_title | Immunology letters |
| container_volume | 97 |
| creator | Morgan, B. Paul Marchbank, Kevin J. Longhi, M. Paula Harris, Claire L. Gallimore, Awen M. |
| description | The complement system, a pillar of innate immunity, has belatedly become recognised as a key modulator of adaptive immunity, acting to direct, modulate and modify the responses of lymphocytes to stimuli. These effects are mediated by interactions between complement components or activation-derived fragments and specific binding proteins—complement receptors and regulators—on the target cells. This review will describe the current state of knowledge in this swiftly moving field. It is hoped that the recognition of these properties will help to establish complement in the role it richly deserves as the lynchpin of immunity. |
| doi_str_mv | 10.1016/j.imlet.2004.11.010 |
| format | Article |
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It is hoped that the recognition of these properties will help to establish complement in the role it richly deserves as the lynchpin of immunity.</description><identifier>ISSN: 0165-2478</identifier><identifier>EISSN: 1879-0542</identifier><identifier>DOI: 10.1016/j.imlet.2004.11.010</identifier><identifier>PMID: 15752555</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Antigens - immunology ; B lymphocyte ; B-Lymphocytes - immunology ; Complement ; Complement System Proteins - immunology ; Complement System Proteins - metabolism ; Humans ; Immunity, Innate - immunology ; Lymphocyte Activation ; T lymphocyte ; T-Lymphocytes - immunology</subject><ispartof>Immunology letters, 2005-03, Vol.97 (2), p.171-179</ispartof><rights>2004 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-6d7efaffa07b3198058f52134ebc9b32373a984ee2e526e7254e58383339a76b3</citedby><cites>FETCH-LOGICAL-c419t-6d7efaffa07b3198058f52134ebc9b32373a984ee2e526e7254e58383339a76b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165247804003141$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15752555$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morgan, B. 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| fulltext | fulltext |
| identifier | ISSN: 0165-2478 |
| ispartof | Immunology letters, 2005-03, Vol.97 (2), p.171-179 |
| issn | 0165-2478 1879-0542 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antigens - immunology B lymphocyte B-Lymphocytes - immunology Complement Complement System Proteins - immunology Complement System Proteins - metabolism Humans Immunity, Innate - immunology Lymphocyte Activation T lymphocyte T-Lymphocytes - immunology |
| title | Complement: central to innate immunity and bridging to adaptive responses |
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