Rhinophototherapy: A new therapeutic tool for the management of allergic rhinitis
Phototherapy has a profound immunosuppressive effect and is able to inhibit hypersensibility reactions in the skin. We evaluated whether phototherapy using a combination of UV-B (5%), UV-A (25%), and visible light (70%), referred to as mUV/VIS, is effective in treating allergic rhinitis. We conducte...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 2005-03, Vol.115 (3), p.541-547 |
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| creator | Koreck, Andrea I. Csoma, Zsanett Bodai, Laszlo Ignacz, Ferenc Kenderessy, Anna Szabo Kadocsa, Edit Szabo, Gabor Bor, Zsolt Erdei, Anna Szony, Barnabas Homey, Bernhard Dobozy, Attila Kemeny, Lajos |
| description | Phototherapy has a profound immunosuppressive effect and is able to inhibit hypersensibility reactions in the skin.
We evaluated whether phototherapy using a combination of UV-B (5%), UV-A (25%), and visible light (70%), referred to as mUV/VIS, is effective in treating allergic rhinitis.
We conducted a randomized, double-blind study, in 49 patients with hay fever. The study was performed during the ragweed season. Each intranasal cavity was illuminated 3 times a week for 3 weeks with mUV/VIS or with low-intensity visible light. Symptom scores, inflammatory cells, and their mediators were assessed in nasal lavages.
In vitro effects of mUV/VIS irradiation on T-cell and eosinophil apoptosis and its inhibitory effect on mediator release from basophils were examined.
Rhinophototherapy was tolerated well and resulted in a significant improvement of clinical symptoms for sneezing (
P < .016), rhinorrhea (
P < .007), nasal itching (
P < .014), and total nasal score (
P < .004). None of the scores improved significantly in the control group. Scores for nasal obstruction slightly improved after mUV/VIS treatment and significantly increased in the control group (
P < .017). In the nasal lavage, phototherapy significantly reduced the number of eosinophils and the level of eosinophil cationic protein and IL-5.
In vitro irradiation of T cells and eosinophils with mUV/VIS light dose-dependently induced apoptosis. Furthermore, mUV/VIS irradiation inhibited the mediator release from RBL-2H3 basophils.
These results suggest that phototherapy is an effective modality to treat allergic rhinitis and offer new options for the treatment of immune-mediated mucosal diseases. |
| doi_str_mv | 10.1016/j.jaci.2004.11.005 |
| format | Article |
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We evaluated whether phototherapy using a combination of UV-B (5%), UV-A (25%), and visible light (70%), referred to as mUV/VIS, is effective in treating allergic rhinitis.
We conducted a randomized, double-blind study, in 49 patients with hay fever. The study was performed during the ragweed season. Each intranasal cavity was illuminated 3 times a week for 3 weeks with mUV/VIS or with low-intensity visible light. Symptom scores, inflammatory cells, and their mediators were assessed in nasal lavages.
In vitro effects of mUV/VIS irradiation on T-cell and eosinophil apoptosis and its inhibitory effect on mediator release from basophils were examined.
Rhinophototherapy was tolerated well and resulted in a significant improvement of clinical symptoms for sneezing (
P < .016), rhinorrhea (
P < .007), nasal itching (
P < .014), and total nasal score (
P < .004). None of the scores improved significantly in the control group. Scores for nasal obstruction slightly improved after mUV/VIS treatment and significantly increased in the control group (
P < .017). In the nasal lavage, phototherapy significantly reduced the number of eosinophils and the level of eosinophil cationic protein and IL-5.
In vitro irradiation of T cells and eosinophils with mUV/VIS light dose-dependently induced apoptosis. Furthermore, mUV/VIS irradiation inhibited the mediator release from RBL-2H3 basophils.
These results suggest that phototherapy is an effective modality to treat allergic rhinitis and offer new options for the treatment of immune-mediated mucosal diseases.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2004.11.005</identifier><identifier>PMID: 15753902</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>Allergic rhinitis ; Allergies ; Apoptosis ; Apoptosis - radiation effects ; Disease ; Drug dosages ; eosinophils ; Eosinophils - radiation effects ; Flow Cytometry ; Hay fever ; Histamine ; Humans ; IL-5 ; Investigations ; Light ; Light therapy ; Nasal Mucosa - immunology ; Nasal Mucosa - radiation effects ; Nose ; Phototherapy ; Rhinitis, Allergic, Perennial - therapy ; T cells ; T-Lymphocytes - radiation effects ; Treatment Outcome ; Ultraviolet Rays</subject><ispartof>Journal of allergy and clinical immunology, 2005-03, Vol.115 (3), p.541-547</ispartof><rights>2005 American Academy of Allergy, Asthma and Immunology</rights><rights>Copyright Elsevier Limited Mar 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-30fa40068edcf31105884aa1a170edeb2b62c4cea87fc3d7059ae2da32997b953</citedby><cites>FETCH-LOGICAL-c448t-30fa40068edcf31105884aa1a170edeb2b62c4cea87fc3d7059ae2da32997b953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S009167490403043X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15753902$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koreck, Andrea I.</creatorcontrib><creatorcontrib>Csoma, Zsanett</creatorcontrib><creatorcontrib>Bodai, Laszlo</creatorcontrib><creatorcontrib>Ignacz, Ferenc</creatorcontrib><creatorcontrib>Kenderessy, Anna Szabo</creatorcontrib><creatorcontrib>Kadocsa, Edit</creatorcontrib><creatorcontrib>Szabo, Gabor</creatorcontrib><creatorcontrib>Bor, Zsolt</creatorcontrib><creatorcontrib>Erdei, Anna</creatorcontrib><creatorcontrib>Szony, Barnabas</creatorcontrib><creatorcontrib>Homey, Bernhard</creatorcontrib><creatorcontrib>Dobozy, Attila</creatorcontrib><creatorcontrib>Kemeny, Lajos</creatorcontrib><title>Rhinophototherapy: A new therapeutic tool for the management of allergic rhinitis</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Phototherapy has a profound immunosuppressive effect and is able to inhibit hypersensibility reactions in the skin.
We evaluated whether phototherapy using a combination of UV-B (5%), UV-A (25%), and visible light (70%), referred to as mUV/VIS, is effective in treating allergic rhinitis.
We conducted a randomized, double-blind study, in 49 patients with hay fever. The study was performed during the ragweed season. Each intranasal cavity was illuminated 3 times a week for 3 weeks with mUV/VIS or with low-intensity visible light. Symptom scores, inflammatory cells, and their mediators were assessed in nasal lavages.
In vitro effects of mUV/VIS irradiation on T-cell and eosinophil apoptosis and its inhibitory effect on mediator release from basophils were examined.
Rhinophototherapy was tolerated well and resulted in a significant improvement of clinical symptoms for sneezing (
P < .016), rhinorrhea (
P < .007), nasal itching (
P < .014), and total nasal score (
P < .004). None of the scores improved significantly in the control group. Scores for nasal obstruction slightly improved after mUV/VIS treatment and significantly increased in the control group (
P < .017). In the nasal lavage, phototherapy significantly reduced the number of eosinophils and the level of eosinophil cationic protein and IL-5.
In vitro irradiation of T cells and eosinophils with mUV/VIS light dose-dependently induced apoptosis. Furthermore, mUV/VIS irradiation inhibited the mediator release from RBL-2H3 basophils.
These results suggest that phototherapy is an effective modality to treat allergic rhinitis and offer new options for the treatment of immune-mediated mucosal diseases.</description><subject>Allergic rhinitis</subject><subject>Allergies</subject><subject>Apoptosis</subject><subject>Apoptosis - radiation effects</subject><subject>Disease</subject><subject>Drug dosages</subject><subject>eosinophils</subject><subject>Eosinophils - radiation effects</subject><subject>Flow Cytometry</subject><subject>Hay fever</subject><subject>Histamine</subject><subject>Humans</subject><subject>IL-5</subject><subject>Investigations</subject><subject>Light</subject><subject>Light therapy</subject><subject>Nasal Mucosa - immunology</subject><subject>Nasal Mucosa - radiation effects</subject><subject>Nose</subject><subject>Phototherapy</subject><subject>Rhinitis, Allergic, Perennial - therapy</subject><subject>T cells</subject><subject>T-Lymphocytes - radiation effects</subject><subject>Treatment Outcome</subject><subject>Ultraviolet Rays</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEGL1TAQx4Mo7nP1C3iQguCtdSZt2kS8LIuuwoIoeg556XRfSts8k9Rlv70p74GwB0_DDL_5M_Nj7DVChYDt-7EajXUVB2gqxApAPGE7BNWVreTiKdsBKCzbrlEX7EWMI-S-luo5u0DRiVoB37HvPw5u8ceDTz4dKJjjw4fiqljovji1tCZni-T9VAw-bMNiNou5o5mWVPihMNNE4S4zIQe55OJL9mwwU6RX53rJfn3-9PP6S3n77ebr9dVtaZtGprKGwTQAraTeDjUiCCkbY9BgB9TTnu9bbhtLRnaDrfsOhDLEe1Nzpbq9EvUle3fKPQb_e6WY9OyipWkyC_k16u1vIbHL4NtH4OjXsOTbNApoJG9b2WaKnygbfIyBBn0MbjbhQSPoTbce9aZbb7o1os6689Kbc_S6n6n_t3L2m4GPJ4CyiT-Ogo7W0WKpd4Fs0r13_8v_C3W_kNI</recordid><startdate>20050301</startdate><enddate>20050301</enddate><creator>Koreck, Andrea I.</creator><creator>Csoma, Zsanett</creator><creator>Bodai, Laszlo</creator><creator>Ignacz, Ferenc</creator><creator>Kenderessy, Anna Szabo</creator><creator>Kadocsa, Edit</creator><creator>Szabo, Gabor</creator><creator>Bor, Zsolt</creator><creator>Erdei, Anna</creator><creator>Szony, Barnabas</creator><creator>Homey, Bernhard</creator><creator>Dobozy, Attila</creator><creator>Kemeny, Lajos</creator><general>Mosby, Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20050301</creationdate><title>Rhinophototherapy: A new therapeutic tool for the management of allergic rhinitis</title><author>Koreck, Andrea I. ; 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We evaluated whether phototherapy using a combination of UV-B (5%), UV-A (25%), and visible light (70%), referred to as mUV/VIS, is effective in treating allergic rhinitis.
We conducted a randomized, double-blind study, in 49 patients with hay fever. The study was performed during the ragweed season. Each intranasal cavity was illuminated 3 times a week for 3 weeks with mUV/VIS or with low-intensity visible light. Symptom scores, inflammatory cells, and their mediators were assessed in nasal lavages.
In vitro effects of mUV/VIS irradiation on T-cell and eosinophil apoptosis and its inhibitory effect on mediator release from basophils were examined.
Rhinophototherapy was tolerated well and resulted in a significant improvement of clinical symptoms for sneezing (
P < .016), rhinorrhea (
P < .007), nasal itching (
P < .014), and total nasal score (
P < .004). None of the scores improved significantly in the control group. Scores for nasal obstruction slightly improved after mUV/VIS treatment and significantly increased in the control group (
P < .017). In the nasal lavage, phototherapy significantly reduced the number of eosinophils and the level of eosinophil cationic protein and IL-5.
In vitro irradiation of T cells and eosinophils with mUV/VIS light dose-dependently induced apoptosis. Furthermore, mUV/VIS irradiation inhibited the mediator release from RBL-2H3 basophils.
These results suggest that phototherapy is an effective modality to treat allergic rhinitis and offer new options for the treatment of immune-mediated mucosal diseases.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>15753902</pmid><doi>10.1016/j.jaci.2004.11.005</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Allergic rhinitis Allergies Apoptosis Apoptosis - radiation effects Disease Drug dosages eosinophils Eosinophils - radiation effects Flow Cytometry Hay fever Histamine Humans IL-5 Investigations Light Light therapy Nasal Mucosa - immunology Nasal Mucosa - radiation effects Nose Phototherapy Rhinitis, Allergic, Perennial - therapy T cells T-Lymphocytes - radiation effects Treatment Outcome Ultraviolet Rays |
| title | Rhinophototherapy: A new therapeutic tool for the management of allergic rhinitis |
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