MutSalpha binds to and promotes synapsis of transcriptionally activated immunoglobulin switch regions

Immunoglobulin class switch recombination joins a new constant (C) region to the rearranged and expressed heavy chain variable (VDJ) region in antigen-activated B cells (Figure 1A) (reviewed in [1, 2]). Switch recombination is activated by transcription of intronic, G-rich and repetitive switch (S)...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Current biology 2005-03, Vol.15 (5), p.470-474
Hauptverfasser:	Larson, Erik D, Duquette, Michelle L, Cummings, W Jason, Streiff, Raphael J, Maizels, Nancy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - metabolism B-Lymphocytes - ultrastructure Base Pair Mismatch Chromatin - metabolism Chromosome Pairing - physiology Cytosine Deaminase - metabolism DNA Primers DNA Repair Enzymes - metabolism DNA Repair Enzymes - physiology DNA-Binding Proteins - isolation & purification DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Electrophoresis, Polyacrylamide Gel Electrophoretic Mobility Shift Assay Immunoglobulin Class Switching - physiology Immunoglobulin Switch Region - physiology Immunoprecipitation Mice Microscopy, Electron MutS Homolog 2 Protein Oligonucleotides Proto-Oncogene Proteins - isolation & purification Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!