Intrathecal fentanyl added to hyperbaric ropivacaine for transurethral resection of the prostate
Background: Our purpose was to evaluate the effect of intrathecal fentanyl 25 µg added to 18 mg of 6 mg ml−1 hyperbaric ropivacaine on the characteristics of subarachnoid block and postoperative pain relief in patients undergoing TURP surgery. Methods: The patients were randomly assigned into two...
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| Veröffentlicht in: | Acta anaesthesiologica Scandinavica 2005-03, Vol.49 (3), p.401-405 |
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| creator | Yegin, A. Sanli, S. Hadimioglu, N. Akbas, M. Karsli, B. |
| description | Background: Our purpose was to evaluate the effect of intrathecal fentanyl 25 µg added to 18 mg of 6 mg ml−1 hyperbaric ropivacaine on the characteristics of subarachnoid block and postoperative pain relief in patients undergoing TURP surgery.
Methods: The patients were randomly assigned into two groups: Group S (saline group, n=16) received 3 ml of 18 mg hyperbaric ropivacaine + 0.5 ml saline – in total, a 3.5‐ml volume intrathecally; and Group F (fentanyl group, n=15) received 3 ml of 18 mg hyperbaric ropivacaine + 0.5 ml of 25 µg fentanyl – in total, a 3.5‐ml volume intrathecally. In both groups the onset and recovery times of the sensory block, degree and recovery times of the motor block and side‐effects were recorded and statistically compared.
Results: There was no significant difference between the groups in achieving the highest level of sensory block, and in the times taken to reach the peak level. Regression to L1 was significantly prolonged in the fentanyl group compared with the saline group (P=0.004). Times to the first feeling of pain and the first analgesic requirement were significantly prolonged in the fentanyl group compared with the saline group (P=0.011 and P=0.016, respectively). The frequency of pruritus was significantly higher in the fentanyl group compared with the saline group (P=0.022).
Conclusion: Addition of fentanyl 25 µg to hyperbaric ropivacaine 18 mg for spinal anesthesia in patients undergoing TURP may significantly improve the quality and prolong the duration of analgesia, without causing a substantial increase in the frequency of major side‐effects. |
| doi_str_mv | 10.1111/j.1399-6576.2005.00607.x |
| format | Article |
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Methods: The patients were randomly assigned into two groups: Group S (saline group, n=16) received 3 ml of 18 mg hyperbaric ropivacaine + 0.5 ml saline – in total, a 3.5‐ml volume intrathecally; and Group F (fentanyl group, n=15) received 3 ml of 18 mg hyperbaric ropivacaine + 0.5 ml of 25 µg fentanyl – in total, a 3.5‐ml volume intrathecally. In both groups the onset and recovery times of the sensory block, degree and recovery times of the motor block and side‐effects were recorded and statistically compared.
Results: There was no significant difference between the groups in achieving the highest level of sensory block, and in the times taken to reach the peak level. Regression to L1 was significantly prolonged in the fentanyl group compared with the saline group (P=0.004). Times to the first feeling of pain and the first analgesic requirement were significantly prolonged in the fentanyl group compared with the saline group (P=0.011 and P=0.016, respectively). The frequency of pruritus was significantly higher in the fentanyl group compared with the saline group (P=0.022).
Conclusion: Addition of fentanyl 25 µg to hyperbaric ropivacaine 18 mg for spinal anesthesia in patients undergoing TURP may significantly improve the quality and prolong the duration of analgesia, without causing a substantial increase in the frequency of major side‐effects.</description><identifier>ISSN: 0001-5172</identifier><identifier>EISSN: 1399-6576</identifier><identifier>DOI: 10.1111/j.1399-6576.2005.00607.x</identifier><identifier>PMID: 15752409</identifier><identifier>CODEN: AANEAB</identifier><language>eng</language><publisher>Oxford, UK; Malden, USA: Blackwell Publishing Ltd/Inc</publisher><subject>Amides - therapeutic use ; Analgesics ; Anesthesia ; Anesthesia, Spinal - methods ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; anesthetics ; Anesthetics, Combined - therapeutic use ; Anesthetics, Intravenous - administration & dosage ; Anesthetics, Intravenous - therapeutic use ; Anesthetics, Local - therapeutic use ; Biological and medical sciences ; Double-Blind Method ; fentanyl ; Fentanyl - administration & dosage ; Fentanyl - therapeutic use ; Humans ; Injections, Spinal - methods ; local ; Male ; Medical sciences ; Middle Aged ; Nerve Block - methods ; opioid ; Pain, Postoperative - prevention & control ; prostatectomy ; ropivacaine ; Sodium Chloride - administration & dosage ; spinal ; Time Factors ; Transurethral Resection of Prostate - methods ; Treatment Outcome</subject><ispartof>Acta anaesthesiologica Scandinavica, 2005-03, Vol.49 (3), p.401-405</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4347-f2828ac58d70cf336c942e6c941d12e6512875f8a96c43fc59df58ed036164ed3</citedby><cites>FETCH-LOGICAL-c4347-f2828ac58d70cf336c942e6c941d12e6512875f8a96c43fc59df58ed036164ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1399-6576.2005.00607.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1399-6576.2005.00607.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16864612$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15752409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yegin, A.</creatorcontrib><creatorcontrib>Sanli, S.</creatorcontrib><creatorcontrib>Hadimioglu, N.</creatorcontrib><creatorcontrib>Akbas, M.</creatorcontrib><creatorcontrib>Karsli, B.</creatorcontrib><title>Intrathecal fentanyl added to hyperbaric ropivacaine for transurethral resection of the prostate</title><title>Acta anaesthesiologica Scandinavica</title><addtitle>Acta Anaesthesiol Scand</addtitle><description>Background: Our purpose was to evaluate the effect of intrathecal fentanyl 25 µg added to 18 mg of 6 mg ml−1 hyperbaric ropivacaine on the characteristics of subarachnoid block and postoperative pain relief in patients undergoing TURP surgery.
Methods: The patients were randomly assigned into two groups: Group S (saline group, n=16) received 3 ml of 18 mg hyperbaric ropivacaine + 0.5 ml saline – in total, a 3.5‐ml volume intrathecally; and Group F (fentanyl group, n=15) received 3 ml of 18 mg hyperbaric ropivacaine + 0.5 ml of 25 µg fentanyl – in total, a 3.5‐ml volume intrathecally. In both groups the onset and recovery times of the sensory block, degree and recovery times of the motor block and side‐effects were recorded and statistically compared.
Results: There was no significant difference between the groups in achieving the highest level of sensory block, and in the times taken to reach the peak level. Regression to L1 was significantly prolonged in the fentanyl group compared with the saline group (P=0.004). Times to the first feeling of pain and the first analgesic requirement were significantly prolonged in the fentanyl group compared with the saline group (P=0.011 and P=0.016, respectively). The frequency of pruritus was significantly higher in the fentanyl group compared with the saline group (P=0.022).
Conclusion: Addition of fentanyl 25 µg to hyperbaric ropivacaine 18 mg for spinal anesthesia in patients undergoing TURP may significantly improve the quality and prolong the duration of analgesia, without causing a substantial increase in the frequency of major side‐effects.</description><subject>Amides - therapeutic use</subject><subject>Analgesics</subject><subject>Anesthesia</subject><subject>Anesthesia, Spinal - methods</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>anesthetics</subject><subject>Anesthetics, Combined - therapeutic use</subject><subject>Anesthetics, Intravenous - administration & dosage</subject><subject>Anesthetics, Intravenous - therapeutic use</subject><subject>Anesthetics, Local - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Double-Blind Method</subject><subject>fentanyl</subject><subject>Fentanyl - administration & dosage</subject><subject>Fentanyl - therapeutic use</subject><subject>Humans</subject><subject>Injections, Spinal - methods</subject><subject>local</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nerve Block - methods</subject><subject>opioid</subject><subject>Pain, Postoperative - prevention & control</subject><subject>prostatectomy</subject><subject>ropivacaine</subject><subject>Sodium Chloride - administration & dosage</subject><subject>spinal</subject><subject>Time Factors</subject><subject>Transurethral Resection of Prostate - methods</subject><subject>Treatment Outcome</subject><issn>0001-5172</issn><issn>1399-6576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtvEzEURi1ERdPCX0DewG4Gezx-SWyiQh9SRSuV1864nmvFYTKT2g4k_x4PidptvfBD_o7v9UEIU1LTMj4sa8q0rgSXom4I4TUhgsh6-wLNHi9eohkhhFacyuYYnaS0LEfWav0KHVMuedMSPUO_roYcbV6Asz32MGQ77Hpsuw46nEe82K0h3tsYHI7jOvyxzoYBsB8jLtiQNhHyIhY0QgKXwzjg0ePyHF7HMWWb4TU68rZP8OawnqJv55-_nl1W1zcXV2fz68q1rJWVb1SjrOOqk8R5xoTTbQPTTDtaNpw2SnKvrBYF8I7rznMFHWGCihY6dore798thR82kLJZheSg7-0A4yYZIVvNiNYlqPZBVzpMEbxZx7CycWcoMZNdszSTRDNJNJNd89-u2Rb07aHG5n4F3RN40FkC7w4Bm4pQXxS5kJ5yQolW0KbkPu5zf0MPu2c3YObzu7IpeLXHQ8qwfcRt_F2-ySQ3P75cGHp--5Pcfv9kFPsHylqlrw</recordid><startdate>200503</startdate><enddate>200503</enddate><creator>Yegin, A.</creator><creator>Sanli, S.</creator><creator>Hadimioglu, N.</creator><creator>Akbas, M.</creator><creator>Karsli, B.</creator><general>Blackwell Publishing Ltd/Inc</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200503</creationdate><title>Intrathecal fentanyl added to hyperbaric ropivacaine for transurethral resection of the prostate</title><author>Yegin, A. ; Sanli, S. ; Hadimioglu, N. ; Akbas, M. ; Karsli, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4347-f2828ac58d70cf336c942e6c941d12e6512875f8a96c43fc59df58ed036164ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Amides - therapeutic use</topic><topic>Analgesics</topic><topic>Anesthesia</topic><topic>Anesthesia, Spinal - methods</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>anesthetics</topic><topic>Anesthetics, Combined - therapeutic use</topic><topic>Anesthetics, Intravenous - administration & dosage</topic><topic>Anesthetics, Intravenous - therapeutic use</topic><topic>Anesthetics, Local - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Double-Blind Method</topic><topic>fentanyl</topic><topic>Fentanyl - administration & dosage</topic><topic>Fentanyl - therapeutic use</topic><topic>Humans</topic><topic>Injections, Spinal - methods</topic><topic>local</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nerve Block - methods</topic><topic>opioid</topic><topic>Pain, Postoperative - prevention & control</topic><topic>prostatectomy</topic><topic>ropivacaine</topic><topic>Sodium Chloride - administration & dosage</topic><topic>spinal</topic><topic>Time Factors</topic><topic>Transurethral Resection of Prostate - methods</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yegin, A.</creatorcontrib><creatorcontrib>Sanli, S.</creatorcontrib><creatorcontrib>Hadimioglu, N.</creatorcontrib><creatorcontrib>Akbas, M.</creatorcontrib><creatorcontrib>Karsli, B.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta anaesthesiologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yegin, A.</au><au>Sanli, S.</au><au>Hadimioglu, N.</au><au>Akbas, M.</au><au>Karsli, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intrathecal fentanyl added to hyperbaric ropivacaine for transurethral resection of the prostate</atitle><jtitle>Acta anaesthesiologica Scandinavica</jtitle><addtitle>Acta Anaesthesiol Scand</addtitle><date>2005-03</date><risdate>2005</risdate><volume>49</volume><issue>3</issue><spage>401</spage><epage>405</epage><pages>401-405</pages><issn>0001-5172</issn><eissn>1399-6576</eissn><coden>AANEAB</coden><abstract>Background: Our purpose was to evaluate the effect of intrathecal fentanyl 25 µg added to 18 mg of 6 mg ml−1 hyperbaric ropivacaine on the characteristics of subarachnoid block and postoperative pain relief in patients undergoing TURP surgery.
Methods: The patients were randomly assigned into two groups: Group S (saline group, n=16) received 3 ml of 18 mg hyperbaric ropivacaine + 0.5 ml saline – in total, a 3.5‐ml volume intrathecally; and Group F (fentanyl group, n=15) received 3 ml of 18 mg hyperbaric ropivacaine + 0.5 ml of 25 µg fentanyl – in total, a 3.5‐ml volume intrathecally. In both groups the onset and recovery times of the sensory block, degree and recovery times of the motor block and side‐effects were recorded and statistically compared.
Results: There was no significant difference between the groups in achieving the highest level of sensory block, and in the times taken to reach the peak level. Regression to L1 was significantly prolonged in the fentanyl group compared with the saline group (P=0.004). Times to the first feeling of pain and the first analgesic requirement were significantly prolonged in the fentanyl group compared with the saline group (P=0.011 and P=0.016, respectively). The frequency of pruritus was significantly higher in the fentanyl group compared with the saline group (P=0.022).
Conclusion: Addition of fentanyl 25 µg to hyperbaric ropivacaine 18 mg for spinal anesthesia in patients undergoing TURP may significantly improve the quality and prolong the duration of analgesia, without causing a substantial increase in the frequency of major side‐effects.</abstract><cop>Oxford, UK; Malden, USA</cop><pub>Blackwell Publishing Ltd/Inc</pub><pmid>15752409</pmid><doi>10.1111/j.1399-6576.2005.00607.x</doi><tpages>5</tpages></addata></record> |
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| subjects | Amides - therapeutic use Analgesics Anesthesia Anesthesia, Spinal - methods Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy anesthetics Anesthetics, Combined - therapeutic use Anesthetics, Intravenous - administration & dosage Anesthetics, Intravenous - therapeutic use Anesthetics, Local - therapeutic use Biological and medical sciences Double-Blind Method fentanyl Fentanyl - administration & dosage Fentanyl - therapeutic use Humans Injections, Spinal - methods local Male Medical sciences Middle Aged Nerve Block - methods opioid Pain, Postoperative - prevention & control prostatectomy ropivacaine Sodium Chloride - administration & dosage spinal Time Factors Transurethral Resection of Prostate - methods Treatment Outcome |
| title | Intrathecal fentanyl added to hyperbaric ropivacaine for transurethral resection of the prostate |
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