Intracellular interferon triggers Jak/Stat signaling cascade and induces p53-dependent antiviral protection

Intracellular interferons (IFNs) exert biological functions similar to those of extracellular IFNs, but the signal transduction pathway triggered by the intracellular ligands has not been fully revealed. We investigated the signaling cascade by sequence-specific knockdown of signaling molecules by m...

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Veröffentlicht in:	Biochemical and biophysical research communications 2005-04, Vol.329 (3), p.1139-1146
Hauptverfasser:	Shin-Ya, Masaharu, Hirai, Hideyo, Satoh, Etsuko, Kishida, Tsunao, Asada, Hidetsugu, Aoki, Fumiko, Tsukamoto, Masako, Imanishi, Jiro, Mazda, Osam
Format:	Artikel
Sprache:	eng
Schlagworte:	Autocrine Cell Line DNA-Binding Proteins - metabolism Fibroblasts - metabolism Fibroblasts - virology Gene Silencing Humans Interferon Interferon-beta - metabolism Intracellular Fluid - metabolism p53 Protein Methyltransferases - metabolism Protein-Arginine N-Methyltransferases RNA interference Sarcoma, Ewing - metabolism Sarcoma, Ewing - virology Signal Transduction - physiology STAT1 STAT1 Transcription Factor Trans-Activators - metabolism Tumor Suppressor Protein p53 - metabolism Vesicular stomatitis Indiana virus - physiology Virus Replication
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