AEE788, a Dual Tyrosine Kinase Receptor Inhibitor, Induces Endothelial Cell Apoptosis in Human Cutaneous Squamous Cell Carcinoma Xenografts in Nude Mice

Purpose: We investigated whether concomitant blockade of the epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR) signaling pathways by AEE788, a dual inhibitor of EGFR and VEGFR tyrosine kinases, would inhibit the growth of cutaneous squamous cell carcinom...

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Veröffentlicht in:	Clinical cancer research 2005-03, Vol.11 (5), p.1963-1973
Hauptverfasser:	Park, Young Wook, Younes, Maher N, Jasser, Samar A, Yigitbasi, Orhan G, Zhou, Ge, Bucana, Corazon D, Bekele, Benjamin N, Myers, Jeffrey N
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antineoplastic agents Apoptosis Biological and medical sciences Carcinoma, Squamous Cell - pathology Cell Proliferation Endothelial Cells epidermal growth factor Humans Medical sciences Mice Mice, Nude molecular targeted therapy Pharmacology. Drug treatments Purines - administration & dosage Purines - pharmacology Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors Signal Transduction Skin Neoplasms - pathology Transplantation, Heterologous vascular endothelial growth factor
Online-Zugang:	Volltext
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