A brainstem paraneoplastic syndrome associated with prostate cancer
Background:Paraneoplastic syndromes are seldom observed with prostate cancer. A rare paraneoplastic brainstem syndrome associated with prostate cancer is described, and the presence of antineuronal antibodies with this syndrome is demonstrated for the first time.Setting:Tertiary referral centre for...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2009-08, Vol.80 (8), p.934-935 |
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| container_title | Journal of neurology, neurosurgery and psychiatry |
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| creator | Berger, J R Bensalem, M Dalmau, J |
| description | Background:Paraneoplastic syndromes are seldom observed with prostate cancer. A rare paraneoplastic brainstem syndrome associated with prostate cancer is described, and the presence of antineuronal antibodies with this syndrome is demonstrated for the first time.Setting:Tertiary referral centre for neurological disorders.Patient:This 59-year-old man developed ophthalmoplegia, dysarthria, dysphagia, pruritus, ataxia, corticobulbar and corticospinal signs in association with prostate cancer. The disorder was unaffected by treatment of the underlying malignancy, but responded initially to high-dose corticosteroid administration and intravenous immunoglobulins.Results:Antibody to intracellular neuronal antigens was demonstrated in both the serum and the cerebrospinal fluid.Conclusions:This unique paraneoplastic syndrome chiefly affecting the brainstem may be a diagnostic clue to the presence of unsuspected prostate adenocarcinoma. Further studies will be required to determine the precise antigenic target. |
| doi_str_mv | 10.1136/jnnp.2008.153015 |
| format | Article |
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A rare paraneoplastic brainstem syndrome associated with prostate cancer is described, and the presence of antineuronal antibodies with this syndrome is demonstrated for the first time.Setting:Tertiary referral centre for neurological disorders.Patient:This 59-year-old man developed ophthalmoplegia, dysarthria, dysphagia, pruritus, ataxia, corticobulbar and corticospinal signs in association with prostate cancer. The disorder was unaffected by treatment of the underlying malignancy, but responded initially to high-dose corticosteroid administration and intravenous immunoglobulins.Results:Antibody to intracellular neuronal antigens was demonstrated in both the serum and the cerebrospinal fluid.Conclusions:This unique paraneoplastic syndrome chiefly affecting the brainstem may be a diagnostic clue to the presence of unsuspected prostate adenocarcinoma. Further studies will be required to determine the precise antigenic target.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp.2008.153015</identifier><identifier>PMID: 19608787</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Antigens ; Ataxia ; Autoantibodies ; Biological and medical sciences ; Brain Stem Neoplasms - complications ; Brain Stem Neoplasms - pathology ; Brain Stem Neoplasms - therapy ; Cancer therapies ; Disease ; Dysphagia ; Eye movements ; Family medical history ; Humans ; Immunoglobulins ; Immunoglobulins, Intravenous - therapeutic use ; Immunohistochemistry ; Larynx ; Male ; Malformations of the nervous system ; Medical sciences ; Metabolic disorders ; Metastasis ; Middle Aged ; Muscle pain ; Neurology ; Paraneoplastic Syndromes, Nervous System - complications ; Paraneoplastic Syndromes, Nervous System - pathology ; Paraneoplastic Syndromes, Nervous System - therapy ; Prostate cancer ; Prostatic Neoplasms - complications ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - therapy</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 2009-08, Vol.80 (8), p.934-935</ispartof><rights>2009 BMJ Publishing Group</rights><rights>2009 INIST-CNRS</rights><rights>Copyright: 2009 2009 BMJ Publishing Group</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b429t-4b3ce3a1a711d048de6d4494ffd4ff469813fb53e2f09efe5bceab9f7f072d913</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jnnp.bmj.com/content/80/8/934.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://jnnp.bmj.com/content/80/8/934.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,780,784,3196,23571,27924,27925,77600,77631</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21718803$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19608787$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berger, J R</creatorcontrib><creatorcontrib>Bensalem, M</creatorcontrib><creatorcontrib>Dalmau, J</creatorcontrib><title>A brainstem paraneoplastic syndrome associated with prostate cancer</title><title>Journal of neurology, neurosurgery and psychiatry</title><addtitle>J Neurol Neurosurg Psychiatry</addtitle><description>Background:Paraneoplastic syndromes are seldom observed with prostate cancer. A rare paraneoplastic brainstem syndrome associated with prostate cancer is described, and the presence of antineuronal antibodies with this syndrome is demonstrated for the first time.Setting:Tertiary referral centre for neurological disorders.Patient:This 59-year-old man developed ophthalmoplegia, dysarthria, dysphagia, pruritus, ataxia, corticobulbar and corticospinal signs in association with prostate cancer. The disorder was unaffected by treatment of the underlying malignancy, but responded initially to high-dose corticosteroid administration and intravenous immunoglobulins.Results:Antibody to intracellular neuronal antigens was demonstrated in both the serum and the cerebrospinal fluid.Conclusions:This unique paraneoplastic syndrome chiefly affecting the brainstem may be a diagnostic clue to the presence of unsuspected prostate adenocarcinoma. Further studies will be required to determine the precise antigenic target.</description><subject>Antigens</subject><subject>Ataxia</subject><subject>Autoantibodies</subject><subject>Biological and medical sciences</subject><subject>Brain Stem Neoplasms - complications</subject><subject>Brain Stem Neoplasms - pathology</subject><subject>Brain Stem Neoplasms - therapy</subject><subject>Cancer therapies</subject><subject>Disease</subject><subject>Dysphagia</subject><subject>Eye movements</subject><subject>Family medical history</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Immunoglobulins, Intravenous - therapeutic use</subject><subject>Immunohistochemistry</subject><subject>Larynx</subject><subject>Male</subject><subject>Malformations of the nervous system</subject><subject>Medical sciences</subject><subject>Metabolic disorders</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Muscle pain</subject><subject>Neurology</subject><subject>Paraneoplastic Syndromes, Nervous System - complications</subject><subject>Paraneoplastic Syndromes, Nervous System - pathology</subject><subject>Paraneoplastic Syndromes, Nervous System - therapy</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - complications</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - therapy</subject><issn>0022-3050</issn><issn>1468-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkM9LHDEUx0NpqVvbe08yUNqLzPa9JDNJjrq0Koi92OItZDIJzjq_TGax_vdmmEXBi4EQQj7v5fs-hHxFWCOy8ue278c1BZBrLBhg8Y6skJcyZwxu3pMVAKU5gwIOyKcYtzAvqT6SA1QlSCHFimxOsiqYpo-T67LRBNO7YWxNnBqbxce-DkPnMhPjYBszuTp7aKbbbAxDnNI1s6a3LnwmH7xpo_uyPw_J39-_rjfn-eWfs4vNyWVecaqmnFfMOmbQCMQauKxdWXOuuPd12rxUEpmvCuaoB-W8KyrrTKW88CBorZAdkh9L3_T__c7FSXdNtK5t59C7qEvBFSJlCfz2CtwOu9CnbBqFRMp5IctEwULZNE4MzusxNJ0JjxpBz3r1rFfPevWiN5Uc7Rvvqs7VLwV7nwn4vgdMtKb1yadt4jNHUaCUMCfMF65J4v8_v5twl6ZgotBX_za6PL2mVxTP9U3ijxe-6rZvx3wCHOegLA</recordid><startdate>20090801</startdate><enddate>20090801</enddate><creator>Berger, J R</creator><creator>Bensalem, M</creator><creator>Dalmau, J</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20090801</creationdate><title>A brainstem paraneoplastic syndrome associated with prostate cancer</title><author>Berger, J R ; Bensalem, M ; Dalmau, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b429t-4b3ce3a1a711d048de6d4494ffd4ff469813fb53e2f09efe5bceab9f7f072d913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Antigens</topic><topic>Ataxia</topic><topic>Autoantibodies</topic><topic>Biological and medical sciences</topic><topic>Brain Stem Neoplasms - complications</topic><topic>Brain Stem Neoplasms - pathology</topic><topic>Brain Stem Neoplasms - therapy</topic><topic>Cancer therapies</topic><topic>Disease</topic><topic>Dysphagia</topic><topic>Eye movements</topic><topic>Family medical history</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Immunoglobulins, Intravenous - therapeutic use</topic><topic>Immunohistochemistry</topic><topic>Larynx</topic><topic>Male</topic><topic>Malformations of the nervous system</topic><topic>Medical sciences</topic><topic>Metabolic disorders</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Muscle pain</topic><topic>Neurology</topic><topic>Paraneoplastic Syndromes, Nervous System - complications</topic><topic>Paraneoplastic Syndromes, Nervous System - pathology</topic><topic>Paraneoplastic Syndromes, Nervous System - therapy</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - complications</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berger, J R</creatorcontrib><creatorcontrib>Bensalem, M</creatorcontrib><creatorcontrib>Dalmau, J</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berger, J R</au><au>Bensalem, M</au><au>Dalmau, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A brainstem paraneoplastic syndrome associated with prostate cancer</atitle><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle><addtitle>J Neurol Neurosurg Psychiatry</addtitle><date>2009-08-01</date><risdate>2009</risdate><volume>80</volume><issue>8</issue><spage>934</spage><epage>935</epage><pages>934-935</pages><issn>0022-3050</issn><eissn>1468-330X</eissn><coden>JNNPAU</coden><abstract>Background:Paraneoplastic syndromes are seldom observed with prostate cancer. A rare paraneoplastic brainstem syndrome associated with prostate cancer is described, and the presence of antineuronal antibodies with this syndrome is demonstrated for the first time.Setting:Tertiary referral centre for neurological disorders.Patient:This 59-year-old man developed ophthalmoplegia, dysarthria, dysphagia, pruritus, ataxia, corticobulbar and corticospinal signs in association with prostate cancer. The disorder was unaffected by treatment of the underlying malignancy, but responded initially to high-dose corticosteroid administration and intravenous immunoglobulins.Results:Antibody to intracellular neuronal antigens was demonstrated in both the serum and the cerebrospinal fluid.Conclusions:This unique paraneoplastic syndrome chiefly affecting the brainstem may be a diagnostic clue to the presence of unsuspected prostate adenocarcinoma. Further studies will be required to determine the precise antigenic target.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>19608787</pmid><doi>10.1136/jnnp.2008.153015</doi><tpages>2</tpages></addata></record> |
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| ispartof | Journal of neurology, neurosurgery and psychiatry, 2009-08, Vol.80 (8), p.934-935 |
| issn | 0022-3050 1468-330X |
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| subjects | Antigens Ataxia Autoantibodies Biological and medical sciences Brain Stem Neoplasms - complications Brain Stem Neoplasms - pathology Brain Stem Neoplasms - therapy Cancer therapies Disease Dysphagia Eye movements Family medical history Humans Immunoglobulins Immunoglobulins, Intravenous - therapeutic use Immunohistochemistry Larynx Male Malformations of the nervous system Medical sciences Metabolic disorders Metastasis Middle Aged Muscle pain Neurology Paraneoplastic Syndromes, Nervous System - complications Paraneoplastic Syndromes, Nervous System - pathology Paraneoplastic Syndromes, Nervous System - therapy Prostate cancer Prostatic Neoplasms - complications Prostatic Neoplasms - pathology Prostatic Neoplasms - therapy |
| title | A brainstem paraneoplastic syndrome associated with prostate cancer |
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